Cystitis

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be random…

This early-phase trial tests a new treatment called LB-DTK-BKV for people who develop painful bladder bleeding (hemorrhagic cystitis) from BK virus after a stem cell transplant. The treatment uses immune cells from a donor that are trained to attack the virus. About 42 children a…

This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will …

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study tests whether a daily probiotic supplement called Colipral® can prevent repeat bladder infections (cystitis) in menopausal women aged 55–70. Participants take either the probiotic or a placebo for 12 weeks and are monitored for 24 weeks to see if they have fewer infect…

This trial compares two approaches for adults with interstitial cystitis, a condition causing long-term bladder pain and frequent urination. All participants receive education and behavioral training, while half also take the antidepressant venlafaxine for 12 weeks. Researchers w…

This study tests a new at-home device called the Floora Pelvic Rehabilitation Vaginal Dilator in 10 women with interstitial cystitis (painful bladder syndrome) and high-tone pelvic floor dysfunction. Participants use the device three times a week for 12 weeks, combining heat and …

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults who receive high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk before serio…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…