Chronic rhinosinusitis

This study tests a drug called TQH2722, a lab-made antibody that blocks inflammation, for people with severe chronic sinusitis (with or without nasal polyps). About 120 adults who completed a prior TQH2722 study will receive either 300mg or 600mg injections over a long period. Re…

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study looked at whether rinsing the nose with diluted povidone-iodine (a common antiseptic) after sinus surgery helps people with chronic sinusitis recover better than standard saline or mucomyst rinses. Forty-eight adults who had sinus surgery used one of the three rinses d…

This study tested whether a dietary supplement called Imunoglukan P4H® (made from pleuran, a mushroom extract, plus vitamin C) could help people with chronic sinusitis. 85 patients over age 12 took the supplement alongside standard treatments like nasal sprays and saline rinses. …

This study compared two types of sinus surgery for people with chronic sinusitis and nasal polyps that involve a type of inflammation called eosinophilic. One surgery (MRESS) removes more tissue, including the middle turbinate, while the standard surgery (FESS) preserves it. The …

This study looked at whether nasal drops made from Pistacia lentiscus oil (a natural plant oil) can help prevent chronic sinusitis from coming back. 100 adults with frequent sinus infections were followed for 12 months. One group used the oil drops plus a saltwater rinse, while t…

This pilot study tests whether adding epinephrine to a standard nerve block (pterygopalatine ganglion block) reduces bleeding during functional endoscopic sinus surgery (FESS) in people with chronic rhinosinusitis. Eighty adults undergoing bilateral FESS will receive the nerve bl…

This study tested whether a numbing injection behind the nose (sphenopalatine ganglion block) could reduce confusion and agitation after sinus surgery. 100 adults received either the nerve block or a placebo. The goal was to see if the block helped patients wake up more calmly an…

This study tested whether rinsing the sinuses with hot saline (50°C) during surgery for chronic sinusitis reduces bleeding and improves the surgeon's view. 59 adults were split into three groups: hot saline, room-temperature saline, or no rinse. The goal was to see if the hot rin…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested two different nasal packs used after nose surgery to see which one patients liked better and which led to better healing. Twenty adults who had nasal surgery received either a VELNEZ or NASOPORE pack. Researchers checked for pain, bleeding, and how well the pack…

This study tested different doses of melatonin (3, 5, and 10 mg) compared to a placebo in 160 adults undergoing sinus surgery. The goal was to see which dose best reduces anxiety and pain while keeping heart rate and blood pressure stable. Results could help doctors choose the ri…

This study tested whether adding a gentle hands-on therapy called craniosacral osteopathic treatment to standard care can improve symptoms and quality of life for people with chronic sinusitis. Fifty adults with the condition were randomly assigned to receive either standard medi…

This study looked at two methods to treat concha bullosa, a condition where the middle turbinate in the nose is enlarged and can block sinuses. 62 adults with chronic sinusitis were randomly assigned to have the turbinate crushed or partially removed during sinus surgery. After o…

This study tested an experimental implant called LYR-210 in 182 adults with long-term sinus inflammation (chronic rhinosinusitis). The goal was to see if it could reduce key symptoms like nasal congestion, discharge, and facial pain better than a placebo. Participants received th…

This study tested a gel called PuraSinus to see if it makes follow-up cleanings after sinus surgery less painful. 30 adults with chronic sinus disease took part. The gel was compared to standard nasal dressings. The goal was to reduce pain and discomfort during these cleanings.

This study tested whether injecting the numbing drug ropivacaine into the nose can reduce pain after endoscopic sinus surgery. 184 adults having sinus surgery were randomly given either ropivacaine or a saltwater placebo injection. The main goal was to measure pain intensity and …

This study tested an experimental drug called brensocatib in 288 adults with long-term sinus inflammation but no nasal polyps. Participants took either 10 mg, 40 mg, or a placebo daily for 24 weeks. The goal was to see if the drug could improve daily symptoms like congestion, run…

This Phase 2 study tested dupilumab (Dupixent) in 33 adults with chronic sinusitis but no nasal polyps. Participants received injections every two weeks for six months. The main goal was to see if the drug improves sinus symptoms and quality of life compared to a placebo.

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study tested whether a nanoemulsified sesame oil nasal spray can improve symptoms and healing after sinus surgery in people with chronic sinusitis. Sixty patients used different nasal solutions after surgery, and researchers measured symptom scores and endoscopic healing. Th…

This study tested whether adding the sedative drug dexmedetomidine to anesthesia improves the view for surgeons during endoscopic sinus surgery. Fifty adults with rhinosinusitis were enrolled. The goal was to see if the drug could make the surgical field clearer, potentially maki…

This study looks at whether anxiety about climate change is linked to worse sinusitis symptoms and lower quality of life in adults with chronic rhinosinusitis. Researchers will ask about 134 adults to complete questionnaires measuring sinus symptoms, quality of life, and climate …

This early lab study from Johns Hopkins University examines how mepolizumab (Nucala) affects the health and function of nasal cells from people with chronic sinusitis and nasal polyps. Researchers will measure changes in inflammation markers and cell barrier integrity. Only 8 par…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study tested whether a French translation of the SN-5 questionnaire, which measures quality of life in children with chronic rhinosinusitis, works as well as the original English version. Researchers asked 89 children (ages 2–12) and their parents to fill out the questionnai…

This study followed 215 people with chronic sinusitis who received a corticosteroid-releasing sinus stent during sinus surgery. Researchers tracked safety and symptom changes over 6 to 12 months using a standard symptom questionnaire. The goal was to confirm the stent's long-term…

This study looked at how mepolizumab, a biologic drug, changes inflammation in people with severe eosinophilic asthma. Researchers measured immune and metabolic markers in the nose, lungs, and blood of 15 adults. The goal was to better understand the drug's full impact beyond jus…

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …