Cerebral infarction

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether adding the anti-inflammatory drug baricitinib to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the front of the brain. About 750 adults will receive either baricitinib or a placebo for five…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study looks at 518 adults with a severe stroke caused by a blockage in the main artery at the back of the brain. It compares two standard treatments: a procedure to remove the clot (endovascular therapy) versus medication alone. The goal is to see which approach leads to bet…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests whether two medicines, isosorbide mononitrate and butylphthalide, can reduce disability in people who recently had a lacunar stroke (a small stroke deep in the brain). About 3,156 adults aged 30 and older will receive one or both drugs or placebos for up to a yea…

This early-phase study tests a new drug called RK-4 for people with a severe type of stroke (large hemispheric infarction) who cannot have standard clot-removal treatment. The drug is injected directly into the skull bone marrow once daily for three days. The main goals are to ch…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This study will check if an artificial intelligence (AI) tool can help less experienced doctors read MRI scans of stroke patients as accurately as a brain scan specialist. About 500 adults who are being evaluated for a stroke will have their MRI results compared. The goal is to s…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study will test whether different frequencies of electroacupuncture (low, medium, or high) can improve swallowing problems in 90 stroke survivors. Participants will receive daily 30-minute sessions over several weeks. The goal is to find the best frequency and understand how…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory respon…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…

This study will observe 125 adults with confirmed stroke to see how factors like symptom awareness, calling emergency services, and transport time affect their recovery. No new treatment is given; instead, researchers will measure stroke knowledge and care pathways to find ways t…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…