Bipolar I disorder

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in adults hospitalized with bipolar I disorder who are currently experiencing a manic or mixed episode. Participants will receive either lumateperone or a placebo daily for s…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested whether adding aripiprazole (Abilify) to the standard mood stabilizer lamotrigine helps prevent relapse in people with bipolar I disorder who recently had a manic or mixed episode. Over 1,100 adults took part, receiving either the combination or lamotrigine alon…

This study looked at whether repeated ketamine infusions can help people with hard-to-treat bipolar depression stay well. 41 adults who had already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if maintenance doses c…

This study tested whether taking a daily probiotic supplement could prevent relapse in people recently hospitalized for mania. Over 24 weeks, 66 participants received either the probiotic or a placebo. The main goal was to see if the probiotic reduced the need for re-hospitalizat…

This study tested whether a new drug called BHV-7000 can safely and effectively treat manic episodes in people with bipolar I disorder. 274 hospitalized adults took either the drug or a placebo once daily for 21 days. The main goal was to see if the drug reduced mania symptoms, m…

This study looked at the long-term safety of cariprazine, a medication, in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, vital signs, lab results, and movement disorders. The goal was…

This study tested whether a new tablet called VHX-896 works the same as the standard drug iloperidone in 26 adults with schizophrenia or bipolar I disorder. Participants took both versions at different times to compare drug levels in the blood and check for side effects. The goal…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This study tested an investigational medication called BXCL501 (dexmedetomidine) given as a film under the tongue for episodes of agitation in people with schizophrenia, schizoaffective disorder, or bipolar disorder. The trial included 452 adults aged 18-75 and compared the drug …

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in people hospitalized with bipolar I disorder. Participants will receive either lumateperone or a placebo daily for several weeks, and researchers will measure changes in ma…

This study tests whether bezafibrate, a drug currently used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar I or II who are already on a mood-stabilizing medication will take bezafibrate for 8 weeks. Researchers will…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This early-stage study tested the safety of a drug called MK-8189 in 34 adults with stable bipolar I disorder. Researchers monitored side effects and how the drug moved through the body. The goal was to see if the drug is safe enough for further testing, not to measure how well i…

This study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This phase 2 trial tested four intravenous ketamine infusions over two weeks in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) to see if ketamine could quickly reduce depression symptoms. The study measured c…

This study followed 120 adults with bipolar I disorder who were having a major depressive episode and starting cariprazine (Vraylar). Researchers measured changes in depression symptoms, daily functioning, and quality of life over 24 weeks in a real-world clinic setting. The goal…

This study tested an experimental drug called ABBV-932 in 161 adults with bipolar I or II disorder who were experiencing a depressive episode. Participants took either the drug or a placebo daily for 6 weeks. Researchers measured changes in depression symptoms using standard rati…

This study tested a new medication, lumateperone, to see if it can safely ease depression in people with bipolar I or II disorder. Over 550 adults took either the drug or a placebo for six weeks. Researchers measured changes in depression symptoms using a standard rating scale.

This study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …

This study tested whether a drug called esketamine works as well as electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression. 340 adults with major depression or bipolar disorder and active suicidal ideas took part. They received either esk…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 26 weeks in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study used a non-invasive brain stimulation technique called theta burst stimulation (TMS) to explore how the brain processes rewards in people with bipolar disorder. Researchers compared brain scans before and after stimulation in 146 adults, both with and without bipolar d…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study from Mayo Clinic looked at whether voice and speech change during manic episodes in people with bipolar I disorder. Researchers recorded interviews with 17 hospitalized participants and analyzed pitch, rhythm, grammar, and word choice. The goal was to find measurable d…

This study tested whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, could improve emotion regulation in people with bipolar disorder. Fifty-six participants, including healthy controls, underwent brain scans while performing tasks design…

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder regulate their emotions. Nineteen participants, including healthy controls, completed behavioral tasks measuring…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study used functional MRI to look at brain activity in people with bipolar disorder while they performed tasks involving language and meaning. The goal was to better understand why some patients experience disorganized thinking or speech. 79 participants took part, including…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study looked at how well people with bipolar I and bipolar II disorder recognize facial emotions compared to healthy individuals. Ten participants completed a facial emotion recognition test and questionnaires. The goal was to see if there are differences between the two bip…

This study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…