Aortic aneurysm

This study tests a new device called the Zenith Fenestrated+ Endovascular Graft, used with special stents, to repair aortic aneurysms that involve arteries to the kidneys and other organs. About 105 people with large or fast-growing aneurysms will be enrolled. The goal is to see …

Researchers test a device that uses a laser to create holes in stent grafts during minimally invasive repair of aortic aneurysms. The holes allow blood to keep flowing to the kidneys and intestines when the aneurysm is close to those arteries. About 15 people who are not good can…

This study is testing a special stent-graft device to repair complex aneurysms in the aorta, the body's main artery. The device is inserted through leg arteries, avoiding open surgery. Researchers will track safety, survival, and quality of life in 760 people over time. The goal …

This study follows 1,500 people who received a GORE® TAG® stent graft to treat aortic conditions like aneurysms or dissections. Researchers will monitor device performance and patient outcomes for up to 10 years. The goal is to confirm that this minimally invasive procedure remai…

This study tests a stent graft that doctors modify to fit each patient's unique aneurysm in the chest and abdomen. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. About 80 people aged 50 and older with large aneurysms will t…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…

This study tests a stent-graft that doctors modify before use to treat complex aortic aneurysms. It involves 20 high-risk patients who cannot have standard open surgery. The goal is to see if the device is safe and prevents aneurysm growth or rupture.

This study compares two ways to keep blood flowing during open surgery for a large aneurysm in the chest and belly. About 236 adults will be randomly assigned to one of two heart-lung machine techniques. Researchers will track serious complications like death, stroke, kidney fail…

This trial tests a physician-modified stent graft to treat juxtarenal aortic aneurysms—a bulge in the aorta near the kidneys—in people who are too high-risk for open surgery. The graft is altered during the procedure to create openings that keep blood flowing to vital branch vess…

This registry is tracking how well two stent grafts, Castor and Cratos, work for treating aortic conditions like dissections and aneurysms. About 100 patients across European hospitals will be followed for up to 5 years. The goal is to see if these devices are safe and effective …

This study tests two types of branch endografts (Zenith t-Branch and Terumo Arch Branch) to treat aortic aneurysms in the chest and abdomen. The devices are placed inside the aorta to reinforce the weakened vessel wall and keep blood flowing to vital organs. Researchers will trac…

This study tests whether spironolactone, a medication that blocks aldosterone, can reduce stiffness in the aorta for people with a thoracic aortic aneurysm. About 50 adults with an enlarged aorta will receive either spironolactone or a placebo for a short time. The goal is to see…

This early study is testing a new stent graft system designed to treat thoracoabdominal aortic aneurysms, a dangerous bulge in the main artery that runs through the chest and belly. The device has special branches to keep blood flowing to vital organs. Researchers will enroll 11 …

This small pilot study is testing whether giving a second treatment with the Nectero EAST system is safe and helpful for people with abdominal aortic aneurysms (a bulging blood vessel in the belly). Ten adults who already had one treatment will get a repeat procedure. The goal is…

This study follows 100 people with thoracoabdominal or pararenal aortic aneurysms who receive the GORE EXCLUDER TAMBE device, a stent-graft system placed through blood vessels. Researchers will track how often the device is successfully implanted and works without leaks or seriou…

This study tests a stent graft that doctors modify by hand to treat complex aortic aneurysms in patients who cannot use standard FDA-approved devices. About 40 high-risk adults will receive the custom graft and be followed for five years to check safety and effectiveness. The goa…

This study tests a doctor-modified stent-graft to treat large aneurysms in the chest and belly area. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. 80 people aged 50 and older with aneurysms meeting standard surgical size c…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This study tests a minimally invasive procedure to treat large aneurysms in the aorta (the main artery) in the chest and belly area. Instead of open surgery, doctors place a fabric-covered metal tube (stent-graft) inside the aneurysm to seal it off. The goal is to see if this app…

This study compares two different stent systems used to repair a weakened area in the main artery (aortic aneurysm). About 126 adults will be randomly assigned to receive either the BeFlared or the VBX stent during a minimally invasive procedure. The goal is to see which device t…

This study tests whether stent-grafts that surgeons customize for each patient's anatomy can safely treat aortic aneurysms. Thirty adults with aneurysms at risk of rupture will receive a physician-modified graft and be followed for five years. The goal is to see if this personali…

This study is testing whether doctors can modify existing stent grafts to treat complex aortic aneurysms in patients who are too high-risk for open surgery and don't qualify for standard devices. The custom grafts are tailored to each patient's anatomy and placed using a minimall…

This study tracks 200 people with complex abdominal aortic aneurysms who receive a custom-made stent graft to reinforce the weakened artery. Researchers measure survival, major complications (like heart attack or stroke), and quality of life using a standard questionnaire. The go…

This study tests three custom-made stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce deaths, lung problems, and hospital stays. About 410 adults with certain types of aortic aneurysms will take part.

This study is testing a minimally invasive procedure using special stent-grafts to treat complex aortic aneurysms in the chest and abdomen. The procedure is designed for patients who are at high risk for traditional open surgery. Researchers will track how well the stents work an…

This study looks at whether specially modified stent grafts can safely treat complex aortic aneurysms (bulges in the main blood vessel) in people who are too high-risk for traditional open surgery. Researchers will track 50 patients to see how many have serious complications like…

This study tracks 70 people receiving the NEXUS aortic arch stent graft, a device placed inside the aorta to treat aneurysms (bulging weak spots). Researchers will monitor safety, device failures, and survival for up to 5 years. The goal is to see how well the stent works in rout…

This study is testing whether custom-made or physician-modified stent grafts can safely repair complex aortic aneurysms in people who cannot use standard devices or undergo open surgery. The grafts are tailored to each patient's anatomy, with small holes to keep blood flowing to …

This study tests a new device called the NEXUS aortic arch stent graft system in 110 adults with serious conditions like aortic dissection or aneurysm affecting the aortic arch. The goal is to see if it is safe and effective at repairing the damaged area without major complicatio…

This early-stage trial is testing a new procedure called BAO-G for people with complex aortic aneurysms (bulging of the main artery in the chest and abdomen). The technique uses off-the-shelf stent grafts to rebuild the artery's branches from inside the blood vessel, avoiding maj…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests an artificial intelligence software called Aorta AIM that automatically measures the size of the aorta from CT scans. The aorta can enlarge over time, leading to serious health problems, and accurate measurement is key for monitoring. Researchers will compare the…

This study tests a new guidance system called LumiGuide that uses light instead of X-rays during a complex aortic aneurysm repair procedure (FEVAR). The goal is to see if it reduces the time patients and doctors are exposed to radiation. About 182 adults needing this surgery will…

This study tests whether myofascial release, a gentle hands-on therapy, can help people recover after heart surgery that splits the breastbone. Fifty adults with heart disease will receive either standard physical therapy or standard therapy plus seven daily sessions of myofascia…

This study involves 40 adults undergoing aortic arch surgery to repair aneurysms or dissections. Researchers are testing a new bedside system that measures brain chemicals in near real-time to detect early signs of oxygen deprivation. The goal is to prevent strokes and confusion …

This study looks back at medical records of 105 people who had a minimally invasive surgery called BEVAR to treat complex aortic aneurysms. Researchers want to see if two types of stent grafts (TUVA BX and iCover) are safe and work well. No new treatments are given; the study jus…

This study looks at 20 adults with COL5A gene mutations to find out why some get aortic aneurysms (a bulge in the main artery) and others don't. Researchers will take a small skin sample and study the cells to see differences in how they build and organize tissue. The goal is to …

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study is looking at whether a blood test called NT-proBNP can help predict serious problems like heart attacks or death in people having vascular surgery. Researchers will measure this marker before and after surgery in 200 patients. The goal is to see if the test can identi…

This study is collecting information from 600 patients across Europe who receive custom-made stent-grafts from Cook to treat complex aortic aneurysms or chronic aortic dissections. The goal is to see how well these devices work in everyday medical practice and to track any major …

This study is testing a new imaging drug called 64Cu-DOTA-ECL1i to see if it can show inflammation in the wall of the aorta in people with abdominal aortic aneurysms. About 30 adults with aneurysms and some without will get a PET/CT scan after receiving the drug. The goal is to u…

This study watches how blood clotting changes in 58 people after complex surgery to repair a thoraco-abdominal aortic aneurysm. Researchers will check for complications like kidney injury, heart problems, and clotting issues before and after surgery. The goal is to better underst…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study enrolls women aged 50 and older to measure the size of their abdominal aorta using ultrasound. Researchers will also collect health history and look for risk factors that may be unique to women. The goal is to better understand and detect aortic disease in women. No tr…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study looks at tissue removed from patients with enlarged aortas (aneurysms) during surgery. Researchers want to measure how strong the tissue is and see if that relates to the size or thickness of the aorta. The goal is to better understand what makes an aneurysm likely to …

This study explores whether 3D printed models of a patient's own diseased aorta can help surgeons plan aneurysm surgery more effectively. Ten adults with thoracic or abdominal aortic aneurysms who are scheduled for non-emergency surgery will have their CT scans turned into physic…

This study is collecting information from 150 people who need open surgery for complex aortic aneurysms (a bulge in the main artery). The goal is to see how their quality of life changes after the operation. Researchers will use surveys to measure physical and mental well-being o…

This study will use cardiac MRI to track changes in heart structure and function in 40 patients who have had endovascular repair for aortic disease. Researchers will compare heart measurements taken before surgery and again at 6 and 12 months afterward. The goal is to understand …

This observational study aims to better understand the mechanical properties of the aortic wall in patients with aortic aneurysms or dissection. Researchers will measure tissue strength from samples taken during surgery and compare them to samples from patients without aortic dis…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study is gathering 5,000 people with certain gene changes that raise the risk of aortic disease (like aneurysms or dissections). Researchers will track their health over time to see how these genes affect the condition. The goal is to better predict and manage the disease, n…

This study looks at whether measuring a substance called presepsin in the blood during and after aorta surgery can help doctors decide when to use antibiotics. About 50 adults having surgery for a thoracic aortic aneurysm or dissection will take part. The goal is to see if presep…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study uses exercise MRI to see how the aorta behaves during exercise in people with aortic aneurysm. Researchers will compare these images with tissue samples from surgery. The goal is to help doctors and patients understand safe exercise limits. The study enrolls 35 partici…

This study installs a 'black box' recording system in hybrid operating rooms to capture and analyze errors during vascular procedures. Researchers will study how teamwork, leadership, and the environment affect surgical performance and patient safety. The goal is to identify high…