Stanford University

This phase 2 trial tests whether adding tiprelestat (elafin) to standard care improves outcomes for people with pulmonary arterial hypertension (PAH), a serious lung condition. About 90 adults will receive either a daily injection of tiprelestat or a placebo for 168 days. The mai…

This study looks at whether starting an automated insulin delivery (AID) system within two weeks of a type 1 diabetes diagnosis helps young patients manage their blood sugar more easily. Sixteen youth newly diagnosed with type 1 diabetes will be offered the system and followed fo…

This early study tests whether the drug CAEL-101/anselamimab can bind to and shrink abnormal protein deposits (amyloid) in people with AL amyloidoma. Five adults with measurable amyloid deposits will receive the drug and be monitored for up to 72 weeks. The goal is to see if the …

This early trial tests whether baricitinib, an immune-calming drug already used for arthritis, can reduce heart inflammation in people with cardiac sarcoidosis. Ten adults will take the drug for 16 weeks alongside their usual steroid-sparing medication. Researchers will use PET s…

This phase 2 trial compares a new type of radiation called LATTICE radiotherapy with standard palliative radiation for people who have large metastatic tumors (over 2.5 cm). The LATTICE method delivers a very high dose to the center of the tumor while keeping lower doses to the s…

This study tests whether patients who receive a stem cell transplant can safely stop the immunosuppressant tacrolimus earlier than usual. Fifty participants with blood cancers or disorders will begin tapering tacrolimus around day 60 after transplant, aiming to stop by day 88. Th…

This study tests whether placing a special amnion membrane graft under the nipple during mastectomy can prevent nipple death. The trial will include 30 people having either gender-affirming or preventive mastectomy. Half will get the graft, half a placebo, and doctors will check …

This early-phase study tests whether the drug sarilumab can safely help adults with chronic graft-versus-host disease (cGVHD) that did not improve with the standard drug belumosudil. Ten participants will receive sarilumab alone, and researchers will monitor side effects and drug…

This early-stage study tests whether a combination of total lymphoid irradiation and anti-thymocyte globulin can train the immune system to accept a new liver without lifelong anti-rejection medication. Twelve adult liver transplant recipients will receive the treatment after the…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This early-stage trial tests a new drug called TS1-ASO in 5 children with Timothy Syndrome, a rare genetic condition affecting the heart and brain. The drug is given via spinal injection to see if it is safe and can improve or prevent developmental and behavioral problems. The st…

This study tests whether insulin eye drops can safely protect the optic nerve in people with open-angle glaucoma. About 90 adults will receive either the insulin drops or a placebo once daily. The goal is to see if the drops can slow vision loss without causing side effects.

This study looks at how a surgery called CTAK (corneal tissue addition for keratoplasty) affects vision and quality of life in people with keratoconus or corneal ectasia. About 100 participants will fill out questionnaires before and after surgery. The goal is to see if the proce…

This pilot study tests whether a gentle ultrasound treatment can safely clear harmful waste from the brain in people who have early signs of Alzheimer's but no or mild symptoms. Fifteen adults with amyloid plaques will receive repeated ultrasound sessions or a sham procedure. The…

This early-phase trial tests a personalized cell therapy (rapcabtagene autoleucel) in 20 adults with large B-cell lymphoma who still have traces of cancer after initial treatment. The goal is to see if the therapy can make those traces disappear, potentially lowering the risk of …

This study looks at whether a noninvasive finger monitor can predict how pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device to standard heart ultrasound in 88 women. The goal is to find a simpler way to guide fl…

This study tests whether replacing dirt floors with concrete in rural Bangladeshi homes can reduce stillbirths and deaths in the first month of life. Researchers will follow 196 households for up to 6 years, comparing outcomes for babies born in homes with concrete versus soil fl…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard anti-clotting therapy can prevent another stroke or heart attack. Researchers will enroll 2,000 people who have had a stroke or mini-stroke within the last 180 days and are already taking asp…

This study tests a free online curriculum called Smart Talk, designed for middle and high school students. The goal is to see if the program increases knowledge about cannabis and reduces both the intention to use and actual use. Over 10,000 students from participating schools wi…

This clinical trial tests whether taking daily low-dose aspirin and lansoprazole can prevent preterm birth in pregnant women at high risk. The study uses a special screening method to identify those most likely to benefit. About 670 women will be enrolled, taking the medication f…

This study in Uganda will test whether giving children both the R21 malaria vaccine and two different malaria prevention medicines works better than the vaccine alone. About 1,290 children will take part. The goal is to see if the combination can reduce malaria cases more effecti…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study tests whether a specially designed, better-tasting liquid diet can be used for two weeks by adults with chronic pancreatitis who have bothersome stomach symptoms. The diet is an easy-to-absorb formula that replaces all food for 14 days. Researchers want to see if peopl…

This pilot study tests whether personalized text messages created by a large language model (AI) can encourage people to be more physically active. Fifty adults will receive daily prompts on their iPhones and Apple Watches for 14 days, comparing personalized messages to generic o…

This pilot study tests whether a community health worker (promotora) can help Latinx patients recently diagnosed with colorectal cancer. Sixty participants will either get a navigator for up to 6 months or just a list of social services. The goal is to see if this support improve…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This Stanford study tests whether a short virtual reality mindfulness session can improve mental well-being and reduce anxiety in hospitalized adults. 42 participants will try the VR app and also receive standard care, acting as their own comparison. The goal is to see if immersi…

Stanford University is testing a digital app called Postpartum Companion to see if it helps new mothers recover after childbirth. The app provides videos and articles on physical, emotional, and social wellbeing. Sixty participants will use the app for 12 weeks and share their fe…

This study from Stanford University will test whether personalized audiobooks, created by a large language model (AI) based on a child's interests, can improve the hospital experience for children and reduce anxiety around needles. Twenty hospitalized children will listen to the …

This study tests a 90-minute single-session therapy for teens aged 13-18 who have experienced trauma and are waiting for full treatment. The session teaches coping skills and understanding of trauma cues. About 40 participants will try it, and researchers will check if it's pract…

This study will test whether taking acetaminophen (Tylenol) by mouth works as well as getting it through an IV for pain after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after their operation. The…

This early-stage study will give 20 bladder cancer patients cannabigerol (CBG) gummies before and after surgery to see if they are safe and tolerable. The goal is to improve quality of life and reduce symptoms during recovery. Researchers will monitor side effects and how well pa…

This study tests whether a lower dose of cabergoline can safely prevent lactation and breast discomfort after second-trimester abortion or pregnancy loss. The standard dose works but can be costly and cause side effects. Researchers will enroll 36 people to compare the reduced do…

This study tests whether ganaxolone, a medicine already used for seizures in a rare genetic disorder, can reduce irritability in autistic children aged 5 to 17. About 66 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if it improves em…

This study tests a wearable ultrasound device that targets peripheral nerves to reduce pain without surgery or medication. 90 adults with chronic nerve pain will attend a single visit to receive ultrasound or sham stimulation and report their pain levels. The goal is to see if th…

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool, called MITI 001, is safe for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to restore healthy gut function and ease symptoms. Only 13 adults with specific sign…

This study looks at whether using virtual reality (VR) or augmented reality (AR) headsets can help children aged 4-17 feel less anxious and in less pain during minor procedures like lumbar punctures or heart catheterizations. About 200 kids will be randomly assigned to use a VR h…

This study tests if Acoustic Resonance Therapy (ART) can relieve symptoms of Empty Nose Syndrome (ENS), a condition where past nose surgery leaves patients feeling blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults with…

This study tests whether giving psilocybin (a psychedelic drug) under general anesthesia can hide its mind-altering effects, allowing a truly blinded trial for depression. Ten adults with major depression will receive either psilocybin or placebo during four sessions while asleep…

This study compares two ways of tracking food in a 12-month digital weight loss program: a simplified method where participants only track high-calorie, low-nutrition foods, versus a detailed method where they track all foods and calories. Researchers will enroll 328 adults with …

This study tests a new program to help Hispanic/Latino young adults who survived childhood cancer communicate better with their family and doctors. The program involves a community health worker who meets with the survivor and a support person before and after a clinic visit. The…

Stanford University is testing a music-based intervention called STAMM-S for people aged 14-35 with suicidal thoughts. Participants listen to machine-learning-generated music for 20 minutes daily over 25 days and receive education on using music to improve mood. The study aims to…

This study tests whether a group-based mental health program, adapted from the WHO's Thinking Healthy Programme, can help new mothers with mild to moderate depression. 440 mothers with infants up to 12 months old will either receive the program or usual care at community health c…

This study will test a device called Accuro 3S that uses real-time ultrasound to guide doctors placing epidurals or spinal anesthesia. The goal is to reduce the number of needle attempts and failed blocks, especially in patients who are harder to treat. About 100 adults receiving…

This study tests whether a specially designed virtual therapy platform called Teleo helps children with anxiety or mood disorders stay more engaged in psychotherapy compared to standard video calls. About 156 children will take part, and researchers will measure engagement throug…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This study tests a decision-support toolkit that helps adults with type 1 diabetes prepare for exercise by suggesting the best timing, insulin adjustments, and snacks. Twenty participants will try three different pre-exercise approaches to see which keeps blood sugar safest durin…

This study looks at whether surgically repairing a nail bed injury leads to better nail appearance and less pain compared to just cleaning and bandaging the injury. About 100 people with nail injuries will be randomly assigned to one of the two treatments. The goal is to find out…

This study tests whether using brain wave (EEG) monitoring during anesthesia can reduce postoperative delirium, a common confusion that affects older adults after surgery. About 225 patients will be randomly assigned to receive either standard anesthesia or anesthesia guided by E…

This study tests whether automated text message reminders can encourage people with hearing loss to get hearing aids. About 190 adults who have been recommended hearing aids will receive these texts. The goal is to see if simple reminders can increase the number of people who fol…

This study is testing a new audio-based game called Mystic Pets to see if it can help distract children aged 4-17 from emotional distress while they are in the hospital. About 20 children at Lucile Packard Children's Hospital will try the game and give feedback on how easy and en…

This study tests four diet strategies—cutting high-calorie foods, limiting when you eat, eating more protein, and eating more fiber—in a 12-week online weight loss program. Researchers will enroll 208 adults with overweight or obesity to see which combination helps people lose th…

This study tests whether augmented reality (AR) and virtual reality (VR) can help teenagers aged 11 to 17 overcome their fear of needles and blood. Participants will use a special headset to gradually face their fears in a safe, computer-generated environment. The goal is to redu…

This pilot study tests whether special shoes that vibrate can safely help people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will enroll 20 participants to see if the vibration feedback is tolerable and…

This study tests whether a stellate ganglion block (a nerve block in the neck) can help control symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes a rapid heart rate upon standing. Twenty adults with POTS will receive either the real block or a sham procedu…

This study tests a new device called the Origin Intubation System to help doctors place breathing tubes more easily on the first try. About 15 adults having planned surgery with general anesthesia will take part. The goal is to see if the device reduces time and improves success …

This study tests whether giving a medicine called dexmedetomidine during a second-trimester dilation and evacuation (D&E) can lower the chances of severe grief and post-traumatic stress after the procedure. About 100 people having a D&E in the operating room will be randomly assi…

This study compares two well-known early autism treatments, ESDM and PRT, to see which one helps young children with autism improve their communication skills the most. About 140 children aged 2 to 5 will be randomly assigned to one of the two therapies for 24 weeks. The goal is …

This study compares two different epidural pain relief methods during labor to see which one mothers prefer. About 150 women planning a vaginal delivery will receive standard epidural care and answer short surveys about their pain and satisfaction. The goal is to find out which a…

This study tests an automated programming method for deep brain stimulation (DBS) in people with Parkinson's disease. Fifteen participants who recently had DBS surgery will try the new algorithm and perform motor tasks like walking and finger tapping. The goal is to see if the au…

This study tests a tablet game called Mystic Wizard, designed to help children aged 7-14 who have received a solid organ transplant learn about their daily medications. In the game, players act as a young wizard who must give 'potions' to keep a magical flame (representing their …

This study tests whether a brain stimulation treatment called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to find the best stimulation settings for 80 adults with treatment-resistant depression. The goal is to see if personalize…

This Stanford study aims to find blood markers that show when the body is under heat strain, and to test two cooling devices: a hand-cooling table and a chilled bandana. Thirty healthy adults will exercise in a hot lab to mimic real-world conditions. The goal is to better detect …

This study tests different strategies to encourage family members to join a program that helps them support a loved one with a substance use disorder. Researchers will enroll 100 family members and their loved ones in outpatient treatment. Participants will try various engagement…

This study at Stanford University will test how the brain responds when visual information is turned into patterns of sound or touch. Two hundred blind and sighted participants will use special devices (BrainPort and AI Sight) for 5 weeks. Researchers will use brain scans and per…

This study tests a new curriculum that teaches high school students in construction career programs how building design can impact community health and environmental justice. Forty students aged 14-18 will be randomly assigned to either the new curriculum or the standard one. Ove…

The EMBRACE study tests whether having a research assistant provide health education and support helps low-income and minority patients with serious or terminal illness feel more involved in their healthcare decisions. About 138 adults in the Monterey area will be split into two …

This study looks at how long before anesthesia children should stop taking Miralax for colonoscopy prep. Researchers will measure stomach contents and bowel cleanliness in 200 children who stop Miralax 1, 2, 3, or 4 hours before anesthesia. The goal is to find the safest timing t…

This study tests a digital app called WONE to see if it can help Stanford-affiliated people (ages 18-65) build resilience and manage stress. About 260 participants will use the app, which offers personalized tips and optional wearable data feedback. The goal is to measure how wel…

This Stanford study will look at how an implanted vagus nerve stimulation device changes brain activity in 12 adults with treatment-resistant depression. Researchers will measure brain waves and heart signals to understand the device's effects. It is an early, exploratory study f…

This pilot study from Stanford University will test whether giving parents educational sessions—with or without in-person feeding help—encourages them to introduce allergenic foods (like peanuts, eggs, and milk) to their babies early. The study enrolls 92 healthy full-term infant…

This study aims to understand how medications used during medical procedures affect patients' feelings of liking or disliking the drug. About 100 adults scheduled for surgery will rate their drug liking and have their brain activity measured. The results will help doctors better …

This online study tests whether a short animated storytelling video can increase people's intention to get screened for colorectal cancer. Researchers will recruit 3,000 U.S. adults who have not yet been screened and randomly show them either the animated video or a plain text de…

This study tests whether a safe, non-invasive technique called vagus nerve stimulation can improve memory in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). Researchers will also explore how gut health and early Alzheimer's markers might influence the e…

This study compares two common methods of repairing the uterus during a C-section: lifting the uterus out of the abdomen to stitch it, or leaving it inside. Researchers want to see which method causes less bleeding, less nausea, and a better experience for the mother. About 60 wo…

This study looks at whether a health tracking platform can improve the health of elderly people who are frail. Over 1,000 seniors will use the platform for a year, and researchers will also figure out which health surveys best predict frailty. The goal is to find better ways to p…

This study tests whether a new online program can help families understand their inherited cancer risk and encourage relatives to get low-cost genetic testing. Researchers will enroll 400 adults who carry a cancer-related gene change and their family members. The goal is to see i…

This study collects vital signs like blood pressure, heart rhythm, and heart rate from 50 healthy adults. The data will help researchers create a device that can monitor blood pressure continuously without a cuff. Participants must be between 18 and 64 years old with a BMI betwee…

This study uses smartphone sensors and health questionnaires to measure physical activity and heart health in 15,000 US adults aged 18 and older. Participants will use an app on their iOS or Android phone to track steps, heart rate, and answer health questions. The study also tes…