Can anesthesia hide the trip? new study tests psilocybin for depression without the psychedelic experience
NCT ID NCT07479550
First seen Mar 18, 2026 · Last updated Jun 21, 2026 · Updated 20 times
Summary
This study tests whether giving psilocybin (a psychedelic drug) under general anesthesia can hide its mind-altering effects, allowing a truly blinded trial for depression. Ten adults with major depression will receive either psilocybin or placebo during four sessions while asleep under anesthesia. The goal is to see if this approach is safe and feasible, and to gather early data on whether it might ease depression symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Stanford University
Stanford, California, 94304, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (a psychedelic compound) given under general anesthesia with propofol
What this could lead to
If it works, this could lead to a new way to study psychedelics for depression without patients knowing if they got the drug, improving research quality.
What could go wrong
This is a very small early-phase trial (10 people) testing feasibility, not effectiveness. The approach may not work or may not reduce depression symptoms.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.