Medical College Of Wisconsin

This study compares two radiation methods given before surgery for pancreatic cancer: a high-dose focused approach (SBRT) versus standard radiation with chemotherapy. About 102 people with resectable or locally advanced pancreatic cancer will take part. The goal is to see which m…

This study tests whether adding the drug venetoclax to a standard chemotherapy regimen can help children and young adults whose acute myeloid leukemia (AML) has returned or not responded to treatment. About 40 participants will receive the combination to see if it is safe and eff…

This study compares a 5-day antibiotic treatment to the usual 7-14 day course for children aged 3 months to 18 years hospitalized with uncomplicated pneumonia. The goal is to see if the shorter treatment is just as effective and causes fewer side effects. Participants are randoml…

This study tests a bone marrow transplant for people newly diagnosed with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The transplant uses marrow from a partially matched family member or unrelated donor. The goal is to improve surviv…

This early-phase study tests a new drug called iadademstat combined with a standard chemotherapy (azacitidine) for people with myelodysplastic syndrome (MDS), a bone marrow disorder. The main goal is to find the safest dose of iadademstat for future studies. About 12 adults with …

This study is for people with pancreatic cancer that can be removed by surgery. Researchers want to see if adjusting the treatment plan based on how the cancer responds can help more patients complete all their therapy and have surgery. About 125 adults will take part in this pha…

This study tests whether a genetic test called PurIST can help doctors choose the best chemotherapy for people with pancreatic cancer that can be removed by surgery. About 84 participants will have their tumor's RNA analyzed to guide treatment. The goal is to see if this personal…

This study tests two remote programs—peer support groups and strengths-based case management—for rural adults aged 50+ living with HIV in the Southern U.S. The goal is to improve viral suppression, medication adherence, and quality of life while reducing depression. About 352 par…

This study tests a stem cell transplant method for people under 25 with certain blood cancers. The approach filters out specific immune cells from donated stem cells to lower the risk of graft-versus-host disease (a serious complication) while helping the new cells grow. Up to 40…

This study tests whether giving patients drugs that match their tumor's unique molecular profile can prevent pancreatic cancer from coming back after surgery. It includes 40 adults whose cancer was removed but who have a high risk of recurrence. The approach uses genetic testing …

This study is for people with advanced, gene-mutated non-small cell lung cancer who have not yet started treatment. Researchers want to see if giving radiation to the main lung tumor before starting daily targeted pills (TKI) can keep the cancer from growing longer. About 34 part…

This early-phase study tests whether MRI-guided adaptive radiation therapy can safely control rectal cancer while allowing patients to keep their rectum. About 22 adults with stage I–III rectal cancer will receive radiation that adjusts in real time based on MRI images. The main …

This study aims to help children aged 11-18 with gut-brain disorders like cyclic vomiting and functional dyspepsia. These conditions cause severe nausea, vomiting, and other symptoms, and are often linked to a poorly regulated autonomic nervous system. Researchers will test a per…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function in pregnant people with preeclampsia, a serious condition that can harm both mother and baby. Researchers will measure blood vessel health in the arm, skin, and placenta. The goal is to…

This early-phase study tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are modified in the lab to better recognize and attack cancer cells. …

This study tests whether placing warm sterile fluid into the womb during labor can reduce breathing problems in newborns when the amniotic fluid is stained with thick meconium. About 320 pregnant women at 36 weeks or later will be randomly assigned to receive either this fluid tr…

This study tests whether a specially trained nurse case manager can help formerly incarcerated Black men with poorly controlled type 2 diabetes improve their blood sugar levels, blood pressure, and quality of life. One hundred participants will be randomly assigned to receive eit…

This early-phase study tests a new treatment for adults with B-cell blood cancers (like lymphoma) that have not responded to prior therapies. Participants receive a special type of immune cell (CAR T-cells) along with a targeted drug called pirtobrutinib, which is given before an…

This study tests a two-step treatment for people with multiple myeloma that has come back or stopped responding to other therapies. First, patients receive a drug called talquetamab to help control the cancer, followed by a one-time infusion of their own modified immune cells (ci…

This study tests a new type of CAR-T cell therapy that targets two proteins (CD19 and CD20) on cancer cells, aiming to treat adults with B-cell blood cancers like lymphoma and leukemia that have not responded to other treatments. The therapy uses the patient's own immune cells, w…

This study tests a combination of four drugs (bortezomib, isatuximab, cyclophosphamide, and dexamethasone) in people with newly diagnosed multiple myeloma who also have kidney problems and are eligible for a stem cell transplant. The goal is to see how well this treatment shrinks…

This study tests whether a continuous glucose monitor (CGM) worn on the skin for 10 days can detect diabetes and pre-diabetes in people with cystic fibrosis as accurately as the standard 2-hour oral glucose tolerance test (OGTT). The OGTT is time-consuming and often skipped, so a…

This study is testing a new FDA-approved device that measures electrical signals in the throat to help doctors diagnose GERD and eosinophilic esophagitis more accurately. About 50 adults with chronic reflux or swallowing problems will use the device during an upper endoscopy. The…

This study is testing whether a new technology called optical coherence tomography (OCT) can help doctors more accurately diagnose ear infections in children. About 235 children with ear complaints will get a standard exam plus an OCT scan. Researchers will compare how often anti…

This study looks at whether a bedside ultrasound done during a regular clinic visit can accurately diagnose fatty liver disease. Researchers will compare the results from the portable ultrasound with standard radiology imaging. The goal is to make diagnosis faster and more conven…

This study tests whether giving theophylline, a drug used for asthma, soon after birth can prevent kidney injury in newborns with HIE (a lack of oxygen to the brain) who are treated with cooling therapy. About 30 infants will receive the drug to see if it is safe and to plan a la…

This study looks at whether using a sit-stand desk can help prevent type 2 diabetes in people who are overweight and sit a lot at work. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to a con…

This study tests if providing healthy meals, nutrition support, and health coaching to pregnant women at high risk can prevent conditions like gestational diabetes and preeclampsia. 100 participants will either receive standard care or the full program. Researchers will compare o…

This study tests whether a special compression garment called the SPIO Core-Max can help infants with cerebral palsy control their head, trunk, and arms better. About 30 babies aged 6 to 18 months will wear the brace and be tracked for 6 months. The goal is to see if it improves …

This study looks at whether doing special balance exercises before surgery or radiation helps people with a small vestibular schwannoma (a non-cancerous brain tumor) keep their balance better after treatment. About 36 adults will either do the exercises or not, and their balance …

This study tests a special exercise method called low load blood flow restriction training for people with disabilities. It uses a cuff to lightly restrict blood flow, allowing lighter weights to still build muscle. The goal is to see if this approach can improve strength and arm…

This study tests whether a gentle magnetic pulse to the brain (TMS) combined with language therapy can improve word-finding in people who have trouble speaking after a stroke. About 50 adults who had a left-brain stroke at least one month ago will take part. The goal is to see if…

This study looks at three different ways to manage pain after childbirth in women who are being treated for opioid use disorder. The goal is to find which method works best for pain, and whether it also helps reduce anxiety, depression, and improve overall well-being. About 20 wo…

This study tests whether wearing an external band around the upper throat can reduce nighttime symptoms like cough, choking, or regurgitation in people with GERD. About 350 adults with reflux-related ear, nose, and throat issues will try the band and report how their symptoms cha…

This study tests whether an over-the-counter supplement called MitoQ and a technique called ischemic conditioning (briefly restricting blood flow to the arm) can improve blood vessel health in 30 stroke survivors. Participants will have their blood vessel function measured before…

This study tests if a gentle, non-invasive nerve stimulation device can reduce stomach and gut symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related conditions like POTS. The treatment targets the vagus nerve, which connects the brain and gut.…

This study compares two ways to treat benign (non-cancerous) narrowing of the esophagus: placing a temporary stent early or only after repeated dilations fail. About 20 adults with trouble swallowing will be followed for at least 2 years. The goal is to see which approach helps k…

This study tests whether metformin, a common diabetes medicine, is safe and tolerable for premature infants with bronchopulmonary dysplasia (BPD), a chronic lung disease. About 40 babies will receive oral metformin to see if it can reduce lung injury and promote lung growth. The …

This study tests a special device that exercises the throat muscles to improve swallowing in people with dysphagia (trouble swallowing). About 160 adults, including healthy seniors and those with swallowing issues, will use the device three times daily for six weeks. The goal is …

This study tests a special way of delivering whole-brain radiation (called pulsed reduced dose-rate) to see if it causes fewer memory and thinking problems. About 53 adults with solid tumors that have spread to the brain will receive 10 daily treatments. The goal is to complete t…

This study tests a non-invasive ear stimulation device that targets the vagus nerve to reduce vomiting episodes in children with Cyclic Vomiting Syndrome (CVS). About 120 children with CVS will either receive the active device or a sham (inactive) device to see if it safely lesse…

This study involves 20 adults undergoing awake brain surgery for tumors in the hand movement area. Researchers will test different electrical stimulation settings to see which ones help or hinder hand movement. The goal is to improve how surgeons monitor hand strength during surg…

This study looks at 300 pregnant women whose babies have gastroschisis (a birth defect where the intestines stick out of the belly). Half will deliver at 35 weeks, the other half at 38 weeks. The goal is to see which timing leads to fewer serious problems like stillbirth, newborn…

This study is for adults with aggressive cancers that have a poor outlook. Researchers want to see if using a detailed analysis of a person's tumor (their 'molecular profile') can help doctors choose a more effective, personalized treatment. The study will enroll 400 people and t…

This study looks at how the muscles that help control bowel movements work and get tired. Researchers want to see if doing special exercises can make these muscles stronger and reduce bowel leakage. The study includes healthy people and those with fecal incontinence, all aged 18 …

This early-phase study looks at how a natural cell process called autophagy affects small blood vessel function in adults with type 2 diabetes. Researchers will compare 60 participants with and without diabetes, giving some a supplement called trehalose (thought to boost autophag…

This study is looking for a way to diagnose and track soft tissue sarcoma using a blood test instead of repeated tissue biopsies. Researchers will collect blood and tumor samples from 50 adults with sarcoma to see if DNA from the tumor found in the blood can help doctors monitor …

This study aims to discover hidden heart electrical problems in high-risk pregnancies that might lead to fetal death. Researchers will use a new, non-invasive monitor called fetal magnetocardiography (fMCG) on 30 pregnant women with conditions like congenital heart disease or twi…

This study aims to understand how the upper part of the esophagus moves during swallowing and how it is affected by the earlier pharyngeal phase. Researchers will measure pressures and movements in the throat and esophagus using special probes and X-ray videos. The study includes…

This study will follow 40 people having standard oral cancer surgery to understand why some get infections. Researchers will track bacteria from the mouth, nose, and throat to see where infections come from. They will also measure antibiotic levels in tissues and blood. The goal …

This study aims to understand how the upper part of the esophagus and throat normally prevent stomach contents from flowing backward into the throat. Researchers will measure muscle pressures and use a camera to detect when acid actually reaches the throat. The study includes 300…

This study gathers information from medical records of 200 adults with B-cell acute lymphoblastic leukemia who received the drug blinatumomab as part of their treatment. The goal is to see how many patients achieve complete remission and how long they survive. No new treatments a…

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study looks at how social needs like food, housing, or transportation affect self-care and health in African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand these challenges and design a program that fits their culture.…

This study looks at how small blood vessels in frail older adults handle the stress of intense exercise. Researchers want to see if a simple technique called ischemic conditioning—using a blood pressure cuff to briefly restrict blood flow—can protect the vessels. Sixty adults age…

This study looks at breast cancer risk and screening in people aged 30-75 who are on hormone therapy. Researchers will collect imaging data and interview participants to understand barriers to screening. The goal is to improve early detection and care for this group.

This study aims to see if allowing people at high risk for anal cancer to collect their own samples at home leads to more completed screenings. Researchers will compare attendance at follow-up appointments between those who self-sample and those who have a healthcare provider col…

This study looks at whether small differences in genes make very low birth-weight babies more likely to develop serious health issues like chronic lung disease. Researchers will also check if certain blood markers can help identify which infants are at highest risk. The goal is t…

This study looks at why some hormone-positive breast cancers become resistant to anti-estrogen treatment. About 100 women with early-stage breast cancer will receive standard hormone therapy for 4-12 weeks before surgery. Researchers will analyze tumor samples to find changes in …

This study looks at medical records from 1,000 adults with pancreatic cancer to see if personalized treatments based on each tumor's molecular profile work better than standard care. Researchers will check how often doctors follow treatment recommendations from a special tumor bo…

This study aims to learn the step-by-step process that leads to type 1 diabetes by studying families where at least one member has the condition. Researchers will collect blood samples, medical history, and measurements from 4,000 participants over 10 years. The goal is to unders…

This study looks at whether singing, alone or in a group, is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it might help lower heart disease risk. The study involves 32 participants and focuses on h…

This study looks at how tumors and nearby healthy organs change in size and shape during and after radiation therapy. By analyzing scans from 500 people who have already completed radiation, researchers hope to learn more about these changes. The goal is to use this information t…

This study looks at why stroke survivors' leg muscles get tired faster than normal. Researchers will measure blood flow to the leg during exercise and test a safe, non-invasive technique called ischemic conditioning to see if it can improve blood flow and reduce muscle fatigue. T…

This study looks at how a special throat exerciser affects swallowing in healthy young and older adults. Researchers want to see if the device makes the muscles used for swallowing work harder. The goal is to gather basic information, not to treat any condition. About 60 healthy …

This study follows up to 500 people who received CAR-T cell therapy for blood cancers like leukemia, lymphoma, or multiple myeloma. Researchers will track participants for up to 15 years to see if any new cancers develop. The goal is to understand the long-term safety of this tre…

This study looks at whether small, natural differences in a gene called PTGS-1 make some babies more likely to develop a serious lung condition (PPHN) if their mothers took over-the-counter pain medicines like ibuprofen during pregnancy. Researchers will compare 200 newborns—some…