Medical College Of Wisconsin

This study tested a stem cell transplant from a half-matched (haploidentical) donor in 32 people with severe aplastic anemia, a condition where the bone marrow fails to make enough blood cells. The main goal was to see how many participants were alive one year after the transplan…

This study tested a new form of the drug melphalan (EVOMELA) combined with other treatments before a stem cell transplant from a half-matched donor. It included 43 adults with blood cancers like multiple myeloma. The goal was to see if the treatment was safe and helped patients l…

This study tested a telephone-delivered program for 100 African Americans aged 50 and older with poorly controlled type 2 diabetes. The program combined diabetes self-management education with help resolving unmet social needs, like food or housing. Participants were randomly ass…

This study tested a combination of three drugs (bevacizumab, atezolizumab, and rucaparib) in 30 people with recurrent or progressive endometrial cancer that had not responded to prior treatments. The goal was to see if the combination could shrink tumors or slow cancer growth. Pa…

This study tested whether taking a probiotic supplement for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if changing gut health might lower heart…

This study tested a mix of six Chinese herbs, called Anti-tumor B, in 30 people with squamous cell cancer of the mouth. Participants took the herbal blend before their planned surgery to see if it could slow cancer cell growth. The main goal was to measure changes in a marker cal…

This study looked at whether taking a specific probiotic (Lactobacillus plantarum 299v) for 12 weeks could improve exercise ability and blood vessel health in people with chronic heart failure. Ten adults with heart failure participated. The goal was to see if the probiotic could…

This study tested a shorter, higher-dose radiation treatment given before surgery for soft tissue sarcoma in the arms, legs, or chest wall. 35 adults with early-stage sarcoma took part to see if this approach was safe and could control the cancer. The goal was to reduce side effe…

This pilot study tested a new order of treatment for people with brain metastases (cancer that spread to the brain). Instead of surgery first, patients received focused radiation (gamma knife) before surgical removal of the tumor. The study included 11 adults with 1 to 4 brain tu…

This study tested whether delivering support through existing friend groups helps people living with HIV stay in medical care and reduce heavy drinking. Researchers enrolled 341 adults in St. Petersburg, Russia, who were HIV-positive and part of social networks with other HIV-pos…

This study tested a new treatment called anti-BCMA CAR T-cells (bb2121) in 40 adults with multiple myeloma who had a poor response after a stem cell transplant and maintenance therapy. The goal was to see if this one-time cell therapy could help achieve a complete remission. Whil…

This study tested a bone marrow transplant from a half-matched donor (haploidentical) in 95 children and adults with severe sickle cell disease. The goal was to see if the transplant could help patients live without major complications for two years. The approach used a reduced-i…

This study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Participants received either diabetes education or extra support tailored to their caregiving challenges. The goal was to see if the p…

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP medication to prevent HIV. The program provided information, motivation, and skills through online modules. 118 participants joined this pilot study to see if the approa…

This study tested whether the drug tildrakizumab can help prevent graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancers. Fifty-one adults took part. The goal was to see if the drug could improve survival without severe GVHD or cancer relaps…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) could better control pain after heart surgery. 62 adults having planned heart surgery through a breastbone incision were enrolled. The…

This small pilot study tested whether combining a gentle, non-invasive brain stimulation technique (high-definition transcranial direct current stimulation) with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants comp…

This study tested a non-invasive procedure called Ischemic Conditioning (IC) in 132 chronic stroke survivors. IC involves briefly restricting blood flow to the leg using a cuff, which may improve nerve and blood vessel function. The goal was to see if this simple treatment could …

This study tested a small, non-invasive device placed on the ear to see if it could reduce nausea in teenagers with functional gastrointestinal disorders. 109 teens took part; half received an active nerve stimulator and half received an inactive one. The goal was to measure chan…

This study tested whether mild electrical stimulation (tDCS) combined with speech therapy can help people with long-term language problems after a stroke. 25 adults with aphasia received both treatments and were tested on naming pictures and reading words. The goal was to see if …

This study tested if giving fewer, higher-dose radiation sessions after surgery for head and neck cancer is safe. 18 adults with certain risk factors received 10, 8, or 5 treatments instead of the usual 30. The goal was to find the shortest schedule that doesn't cause severe side…

This study tested a nerve-freezing technique (cryoanalgesia) during robot-assisted lung surgery to see if it reduces pain afterward. 33 adults having lung surgery were randomly assigned to receive the nerve block or not. Researchers measured pain scores and pain medication use fo…

This study tested a non-invasive nerve stimulator placed on the ear to reduce nausea and vomiting in 47 children and adults with cyclic vomiting syndrome. Participants used the device daily for up to 6 weeks, and researchers tracked symptom severity using standard scales. The goa…

This study looked at how the inner ear responds to sound during and after cochlear implant surgery in 88 people with hearing loss. Researchers used CT scans and hearing tests to see where the implant sits and how much natural hearing is saved. The goal was to learn more about how…

This study looked at 150 women who had a rare but serious heart condition called peripartum cardiomyopathy, which caused cardiogenic shock (when the heart can't pump enough blood). Researchers observed their medical treatments and long-term health over time. The goal was to bette…

This study looked at whether giving antibiotics (vancomycin) to cancer patients with a mild form of C. difficile infection helps. The infection was detected by a sensitive test but not confirmed by a toxin test. The study measured changes in C. difficile levels in stool and gut h…

This study explored how non-caloric artificial sweeteners (like those in diet drinks) affect body fat, muscle, and blood sugar control in young people aged 5-17 with type 1 diabetes. Researchers measured body composition and ran blood tests, and asked participants about their die…

This study tested whether a deeper self-collected swab (5 cm) is better than a shallower one (3 cm) at collecting cells from the area most likely to turn into anal cancer. 50 adults at higher risk for anal cancer participated. The goal was to find the best way to screen for anal …

This study looked at whether an artificial intelligence (AI) device could help teach anesthesiology residents how to use ultrasound to guide numbing injections (regional anesthesia). Twenty residents with no prior experience in this technique used the AI tool, and then filled out…

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used gentle leg movements and muscle contractions to measure blood flow. The goal was to learn more about why stroke survivors often have trouble with …

This study looked at whether giving CPR instructions over the phone to bystanders helps more people get CPR before paramedics arrive. Researchers tracked 274 adults who had a cardiac arrest outside the hospital. The goal was to see if pre-arrival instructions increased the number…

This study tested whether helping low-income African Americans with diabetic kidney disease meet their basic needs (like food, housing, and utilities) could improve their health. Fifty participants received support to address these challenges. The goal was to see if this approach…

This study looked at 20 women who had treatment for node-positive breast cancer between 2000 and 2007, including surgery, chemotherapy, and radiation to the chest. Researchers used cardiac MRI scans to measure heart function and see if there is a safe level of radiation exposure.…

This study looked at brain tissue from 20 glioblastoma patients after they passed away. The goal was to understand how a treatment called tumor treatment fields (TTFields) affects cancer cells at a microscopic level. Researchers counted active and inactive cells to see how the tr…

This study tested whether an animated video sent by text message helps parents prepare for conversations with their doctors during prenatal appointments for fetal anomalies. 48 pregnant people took part, receiving either the video or links to clinic webpages. Researchers compared…