Medical College Of Wisconsin

This study tests a drug called pacritinib in people with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to see if it can slow or stop cancer growth. Participants must have a specific protein marker (STAT5) in their tumor. The study involves 3…

This early-stage study tests a new type of immunotherapy called h20.19 CAR T cells in 24 adults with B-cell lymphoma that has relapsed or not responded to prior treatments. The therapy uses a patient's own immune cells, modified to target two proteins (CD20 and CD19) on cancer ce…

This study tests whether adding two targeted drugs (mosunetuzumab and polatuzumab vedotin) to standard chemotherapy can help older adults (70+) with a newly diagnosed, aggressive type of lymphoma called diffuse large B-cell lymphoma. About 31 participants will receive this combin…

This early-phase study tests a new kind of CAR T cell therapy for people with multiple myeloma that has returned or not responded to at least three prior treatments. The cells are 'armored' to resist signals from the cancer that normally shut them down. The main goal is to check …

This study looks at whether high-protein drinks during labor can help pregnant women with insulin-treated diabetes maintain healthier blood sugar levels. About 60 women will be randomly assigned to drink either a clear protein beverage or standard clear liquids during labor. Part…

This study tests a drug called linvoseltamab in 34 adults with multiple myeloma whose cancer returned after BCMA CAR T-cell therapy. The goal is to see if this bispecific antibody can shrink tumors again. Participants must be at least 18 and have had CAR T therapy at least 6 mont…

This early study tests whether a device that stimulates the brain, combined with physical therapy, can help the brain rewire itself before surgery. The goal is to move important functions away from the tumor area so surgeons can remove more of the tumor without causing lasting ha…

This study tests if virtual, culturally tailored classes on healthy eating and physical activity can help Puerto Rican men lose at least 5% of their body weight. Forty-eight men over age 35 with a BMI of 25 or higher will join either the lifestyle program or a general health grou…

This study tests whether fosamprenavir, an FDA-approved HIV medication, can treat laryngopharyngeal reflux (LPR) in adults who did not improve with standard acid-reducing drugs. LPR causes chronic cough, hoarseness, and throat clearing, and current treatments often fail. About 10…

This study tests whether a blood test before delivery can identify women at high risk for developing dangerous high blood pressure after giving birth. About 60 pregnant women with risk factors will be enrolled, and those found to be high-risk will receive extra monitoring and car…

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers (like acute myeloid leukemia or myelodysplastic syndromes). About 450 adults will be assigned to receive or not r…

This early-phase study tests whether a special cancer vaccine (SV-BR-1-GM) combined with an immunotherapy drug (pembrolizumab) is safe and feasible for people with solid tumors that have spread to the brain or spinal cord. About 20 adults whose cancer has worsened after standard …

This early-phase study tests a new treatment called FT836 CAR T-cell therapy combined with daratumumab in 12 adults with multiple myeloma that has returned or not responded to at least three prior treatments. The main goal is to check safety and find the right dose. Participants …

This study tests whether a dietary supplement called propionic acid (a substance made by gut bacteria) can improve blood vessel function in 20 people with coronary artery disease. Participants will take the supplement for 4 weeks, and researchers will measure changes in artery he…

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests if light therapy can prevent and treat painful mouth sores in children with cancer. About 50 kids will receive light therapy every other day while in the hospital. Researchers will compare their results to past patients who did not get the therapy. The goal is to…

This early-phase study tests whether adding a bile acid called UDCA to standard antibiotics can stop C. diff colitis from returning. About 30 adults with high-risk C. diff will take UDCA for up to 8 weeks alongside their usual treatment. Researchers will track recurrence through …

This study tests whether teaching women about healthy eating, activity, and other lifestyle habits before or during early pregnancy can improve their heart health and lower the chance of problems like gestational diabetes and preeclampsia. Two hundred women at risk for these issu…

This study tests whether mindfulness training, with or without wearable biosensors, can help prevent preeclampsia in pregnant women at moderate to high risk. 90 women will be randomly assigned to one of three groups: mindfulness plus biosensors, mindfulness alone, or standard pre…

This study tests whether a drug called Fosamprenavir-Sodium Alginate (FOS-SA) can reduce heartburn and regurgitation in people whose acid reflux doesn't improve with standard proton pump inhibitors (PPIs). About 60 adults aged 18-65 will take either FOS-SA or a placebo twice dail…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with balance exercises, can improve balance in adults who still have trouble walking steadily after surgery for a neck condition called degenerative cervical myelopathy. About 45 participants wi…

This study tests whether a 16-week lifestyle program focused on healthy eating and exercise can improve physical function, quality of life, and blood markers of aging in people with multiple myeloma. About 184 adults who have had myeloma for at least a year will take part. Partic…

This study tests a new tool that helps doctors and cancer survivors decide together on the best heart-protecting medications and heart scans. About 60 adult cancer survivors who have not yet seen a heart specialist will take part. The goal is to see if the tool is easy to use and…

This study looks at whether the supplement quercetin can improve how small blood vessels function in people with obesity. Forty adults aged 18-40 with a BMI over 30 will take quercetin and have their blood vessel health measured using cameras and small sensors placed on the skin.…

This study looks at why people with type 2 diabetes have dangerously high blood pressure during exercise, which raises their risk of heart attack and stroke. Researchers will test if poor blood vessel function and cell damage cause this problem. The goal is to find new ways to ma…

This study looks at whether a dietary supplement called TA-65 can help blood vessels work better as people age. Researchers will measure blood vessel function in healthy younger and older adults, as well as people with coronary artery disease. The goal is to see if activating tel…

This study looks at whether adding a person's genetic risk score to standard heart disease risk checks helps doctors and patients decide together on prevention steps, like taking statins. About 200 adults aged 40-69 with no prior heart disease or statin use will take part in prim…

This very early (Phase 0) study will give an oral drug called gallium maltolate to 8 people whose glioblastoma has come back. The main goal is to measure how much gallium gets into the tumor tissue after surgery, compared to untreated tumor samples. This trial does not test if th…

This study tests a new, non-invasive forehead thermometer (Temple Touch Pro) in children in the pediatric intensive care unit who need precise temperature control. The goal is to see if this simple sticker-like device can accurately replace internal probes placed in the bladder, …

This study aims to find out why some people regain weight after stopping an injectable weight loss drug. Researchers will measure a brain protein called AgRP in 52 adults whose insurance coverage for the drug is ending. They will track weight changes and hunger levels for 3 month…

This study collects blood samples and medical information from 375 people with non-cancerous blood diseases like aplastic anemia, sickle cell disease, or thalassemia who are receiving a stem cell transplant or gene therapy. Researchers will use the samples to understand why treat…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young adults with type 1 diabetes. Twenty people aged 15-24 will drink a sports drink and have their blood vessel function measured. The goal is to understand if the…