Study targets hidden danger of exercise in diabetes
NCT ID NCT07228208
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at why people with type 2 diabetes have dangerously high blood pressure during exercise, raising their risk of heart attack and stroke. Researchers will test if damaged blood vessels and cell stress are to blame. The study involves 40 adults with and without diabetes doing handgrip exercises. Results may lead to new treatments to make exercise safer and more effective.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Type 2 Diabetes: 18 - 80 years old, able to give informed consent, \> 6 months post-diagnosis, \> 6 months stable medications for management * Healthy controls: 18 - 80 years old, able to give informed consent Exclusion Criteria: * Type 2 Diabetes: Type 1 diabetes, symptomatic coronary artery disease, cardiovascular event in last year (MI, stroke), uncontrolled or unmanaged hypertension (\>160/90 mmHg), heart failure, renal impairments, current or recent (\<6 months) tobacco use, hormone replacement therapy, documented neuromuscular disorders, pregnancy * Healthy Controls: Same as listed in Type 2 Diabetes with Type 2 Diabetes as an exclusion factor
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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