Medical College Of Wisconsin

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney or other solid organ transplant. Researchers will measure antibody levels in 30 participants over 24 months and compare them to healthy individuals. The goal is to see if the vaccine …

This study tests whether a lower-dose combination of two drugs (PTCy and ruxolitinib) can prevent graft-versus-host disease (GVHD) in older adults receiving a stem cell transplant for blood cancer. About 56 participants will receive the treatment and be monitored for survival wit…

This study looks at the best time to start medication for pregnant women with gestational diabetes. 416 women were randomly assigned to begin treatment when either 20% or 40% of their blood sugar readings were too high. The goal is to see which approach leads to fewer health prob…

This early-stage study tests an oral drug called gallium maltolate in 26 adults whose glioblastoma has returned or not responded to standard treatments. The main goal is to find a safe dose and see if it can slow tumor growth. Participants take the drug by mouth and are monitored…

This study tests whether a three-drug combination (isatuximab, lenalidomide, and dexamethasone) can eliminate tiny amounts of multiple myeloma that remain in the bone marrow after a stem cell transplant. It enrolls 30 adults whose cancer is still detectable by a sensitive test. T…

This study tests giving a short course of radiation to the breast tumor before surgery, using MRI for precise targeting. The goal is to treat a smaller area of breast tissue and reduce side effects. About 39 women with early-stage breast cancer will receive radiation, then have s…

This study tests whether giving intensive blood pressure treatment to women right after childbirth can improve their long-term heart health and prevent chronic high blood pressure. Researchers will enroll 60 women who had high blood pressure during pregnancy and follow them for 1…

This study tests whether a probiotic called Lp299v can improve blood vessel function in people with long COVID (PASC). The trial will enroll 80 adults who had COVID-19 in the past 30 to 180 days. Participants will take the probiotic daily, and researchers will measure changes in …

This study tests whether the immunotherapy drug cemiplimab, given before surgery, can eliminate all signs of cancer in high-risk or locally advanced breast cancer patients. It includes 36 adults with hormone receptor-positive or triple-negative breast cancer that has not spread t…

This study looks at 300 people having a procedure for atrial fibrillation (an irregular heartbeat). During the procedure, doctors measure the blood pressure inside the heart's left upper chamber. If it is high, it may mean the heart is struggling with unrecognized heart failure. …

This study looks at whether giving blood pressure medication to women who had preeclampsia during pregnancy can lower their risk of being readmitted to the hospital after giving birth. About 300 women will be randomly assigned to receive either the medication or standard care. Th…

This study tests whether taking a probiotic supplement can lower inflammation in children and teens recently diagnosed with type 1 diabetes. The goal is to see if changing gut bacteria can slow the disease's progression. About 43 participants aged 5-17 will receive either the pro…

This study tests a combination of four drugs (isatuximab, pomalidomide, elotuzumab, and dexamethasone) in people with multiple myeloma that has returned or stopped responding to at least two prior treatments. The goal is to see how well this mix controls the cancer. About 28 adul…

This early-phase study tests a gene therapy for severe hemophilia A in 5 adult men with a history of inhibitors. Doctors take the patient's own blood stem cells, add a gene that makes factor VIII, and return the modified cells. The goal is to see if this approach is safe and can …

This study tests whether a probiotic called Lactiplantibacillus plantarum 299v can reduce inflammation and help preserve the body's ability to produce insulin in people recently diagnosed with type 1 diabetes. About 60 participants aged 3 to 45 will receive either the probiotic o…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This study tests whether a program that helps HIV-positive men who have sex with men build supportive social connections can improve their medical care attendance and overall health. One hundred participants in St. Petersburg, Russia, will receive either standard counseling or co…

This early-phase trial tests a new drug, loncastuximab tesirine, combined with standard chemotherapy (DA-EPOCH-R) in 11 adults with aggressive B-cell lymphoma. The goal is to find the safest dose and see if the combination can control the disease. Participants must have certain t…

This study tests whether a daily probiotic supplement called Lp299v can improve blood vessel health in healthy adults aged 50 to 99. Researchers will measure how well blood vessels expand and relax, and look at changes in gut bacteria. The goal is to see if targeting the gut can …

This study was designed to test a new device that uses sound and heat to measure fat in the liver. It would compare the device's accuracy to standard MRI scans in adults with or suspected of having non-alcoholic fatty liver disease. The goal was to see if this simpler method coul…

This study tests a 4-month community program called Men Moving Forward for African-American men who have finished prostate cancer treatment. The program includes twice-weekly sessions to help them eat more fruits and vegetables, exercise more, and improve their body composition. …

This study tests whether floating in a special tank—where you're isolated from light, sound, and touch—can reduce symptoms of posttraumatic stress disorder (PTSD). About 30 adults with PTSD will take part. Researchers will measure changes in PTSD severity, depression, anxiety, an…

This study tests whether a 3-week interdisciplinary rehab program (IORP) can reduce long-lasting symptoms of traumatic brain injury (TBI) and related disorders in 416 veterans and first responders. Participants will answer surveys about their symptoms and life quality, and some w…

This study tests whether a mild electrical current applied to the brain, combined with speech therapy, can improve language skills in people who have trouble speaking after a stroke. About 200 adults with aphasia from left-sided brain damage will take part. The goal is to see if …

This small pilot study tests whether a low dose of naltrexone (4.5 mg daily for 12 weeks) can reduce central neuropathic pain and improve quality of life in people with traumatic spinal cord injury. Ten adults with cervical or thoracic injuries and nerve pain will take the drug a…

This study looked at whether taking a probiotic supplement for 8 weeks could lower inflammation and ease pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker for inflammation and…

This study looks at whether two special imaging tools, TXI and RDI, can help doctors remove large colon polyps more safely and completely. Adults with large polyps will have standard removal with or without these tools. The goal is to see if the tools reduce bleeding and prevent …

This study looks at how testosterone therapy affects the heart and metabolism of transgender boys and men aged 12 to 30. Researchers will measure changes in blood vessel function, blood pressure, and body composition over one year. The goal is to understand if starting testostero…

This study collects information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal is to …

This study aimed to find better ways to diagnose and treat pharyngeal reflux, where stomach contents reach the throat. Researchers planned to measure throat muscle function and test if pressing on the throat could stop reflux. The study was withdrawn before enrolling any particip…

This study looks for biological markers that may explain why some people experience a larger-than-expected drop in their resting metabolism when they lose weight. Researchers will follow 60 adults with obesity for 18 months, measuring metabolism and hormone levels. The goal is to…

This study is testing better ways to take MRI pictures for people getting radiation therapy for solid tumors. The goal is to find the best scan settings to get clearer, more accurate images. Both cancer patients and healthy volunteers can take part. The study is currently on hold…

This study looks at how genetic testing for breast cancer affects patients' stress and anxiety levels. Researchers will track stress before and after testing in 164 women who either have breast cancer or are at high risk. The goal is to help doctors provide better emotional suppo…

This study tests whether using ultrasound to guide a bone marrow biopsy is better than the usual method of feeling for landmarks on the body. About 100 adult inpatients will be randomly assigned to one of the two methods. The goal is to see if ultrasound reduces pain, improves sa…

This early-stage study tested whether giving a condensed course of radiation (just 5 to 10 sessions) before surgery is safe for people with head and neck cancer. It involved 12 adults with a type of cancer not linked to HPV. The main goal was to see if the shorter radiation cause…

This study looks at how the kidneys use oxygen and process nutrients in people whose blood pressure is sensitive to salt. Researchers will compare 70 adults with and without salt sensitivity using MRI scans and lab tests. The goal is to better understand what causes salt-sensitiv…

This study looks at how Iyengar Yoga might help understand prolonged grief disorder in older adults. About 68 people aged 40 and older who have been grieving for over 6 months will take part. Researchers will measure changes in brain activity and natural chemicals in the body to …

This study aimed to see if adding blood flow restriction (BFR) therapy to standard physical therapy helps people recover better after surgery for a broken shinbone (tibial plateau fracture). BFR uses a cuff to lightly restrict blood flow during exercise, which may reduce muscle l…

This study tests whether realistic simulation training helps caregivers of children with tracheostomies (with or without home ventilators) manage emergencies. About 60 caregivers will be trained using high-tech simulations to see if it reduces hospital readmissions and ER visits.…

This study looks at whether advanced MRI scans can better predict how patients with newly diagnosed glioblastoma respond to Optune therapy compared to standard MRI. About 60 participants will be followed to see how many are alive at six months and one year. The goal is to improve…