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Can tight BP control after pregnancy ward off heart disease?

NCT ID NCT05687344

Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study tests whether intensive blood pressure treatment after childbirth can improve women's long-term heart health. Researchers will enroll 60 women who had high blood pressure during pregnancy and give them nifedipine to keep their BP below 140/90 mmHg. The goal is to see if this approach is feasible and can reduce the risk of chronic hypertension and heart problems later in life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nifedipine (a blood pressure medication)
What this could lead to
If it works, this could show that tight blood pressure control after pregnancy reduces the risk of chronic hypertension and heart disease later in life.
What could go wrong
This is a small, early-phase feasibility study with only 60 participants, so results may not apply broadly. The intensive treatment may also cause side effects like dizziness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * HDP diagnosis (gestational hypertension or preeclampsia) according to ACOG guidelines * Postpartum day 0-3 and prior to discharge * Able to communicate in English or in Spanish * Age 18 - 45 Exclusion Criteria: * Pre-gestational hypertension * Pre-gestational diabetes ( type 1 or type 2) * Intent to transfer postpartum to an outside institution of the participating centers * Known allergy to nifedipine or other significant contraindication to nifedipine * Inability or unwillingness to provide informed consent

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced hypertensive disorder preeclampsia Toxemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertensive disorder of pregnancy

Contacts and locations

Locations

  • Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.