Probiotic drink could turn back the clock on aging arteries
NCT ID NCT05296395
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a probiotic drink called Lp299v (found in GoodBelly StraightShot) can reverse age-related stiffening of blood vessels in healthy adults aged 50 to 99. The 20 participants will take the drink daily and have their blood vessel function measured. It is a small, early-stage trial to see if targeting gut bacteria can improve vascular health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lactobacillus Plantarum 299v (a probiotic) in a fermented oat drink
- What this could lead to
- If it works, this could point toward a simple dietary supplement to help keep blood vessels healthy as people age.
- What could go wrong
- This is a very small early study (20 people) with no placebo comparison yet. The effect may be small or not happen at all, and results may not apply to people with health conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2023
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 99 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ages 50-99 years * For women: 12 months or more since last menstruation Exclusion Criteria: * Systolic Blood Pressure ≥ 130 mmHg or Diastolic BP ≥ 80mmHg * Currently taking pharmacological therapies for hypertension, dyslipidemia, or glucose control * Diabetes (type 1 or 2) or glycosylated hemoglobin ≥ 5/7% * LDL Cholesterol \> 160 mg/dL or Total Cholesterol \> 200 mg/dL * Cigarette use within 3 years of enrollment * Average of \> 7500 steps per day as measured during screening period * Received probiotics, prebiotics, and/or antibiotics within six weeks of enrollment * History of chronic renal insufficiency, liver dysfunction, or cancer besides non-melanoma skin carcinomas or localized prostate cancer requiring systemic treatment within 3 years of enrollment * History of inflammatory rheumatic diseases known to increase atherosclerotic cardiovascular risk (e.g. rheumatoid arthritis, systemic lupus erythematosus) * Known history of cognitive impairment or inability to follow study procedures * GI tract illnesses such as short gut syndrome, inflammatory bowel disease, or an ileostomy * Daily alcohol use
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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