Simple cuff trick may boost walking after stroke
NCT ID NCT04038697
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured walking speed and leg strength to see if this technique could improve mobility.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ischemic conditioning (a procedure using a blood pressure cuff to temporarily stop blood flow to the leg)
- What this could lead to
- If it works, this could offer a simple, non-drug way to help stroke survivors walk faster and improve leg function.
- What could go wrong
- This is a small, early-stage study with no phase designation, so results may not be conclusive. The procedure is safe but may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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132 people
The number who actually took part.
- Started
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Dec 2018
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria (Stroke Survivors): 1. be ≥ 1 year post diagnosis of a unilateral, cortical stroke and have residual lower extremity paresis 2. be between the ages of 18-85 3. be able to give informed consent 4. walk slower than normative values based on age and sex Exclusion Criteria (Stroke Survivors): 1. history of deep vein thrombosis or any condition in which transient ischemia to the lower extremity is contraindicated 2. inability to follow 2 step commands 3. chronic low back or hip pain 4. history of substance abuse 5. history of head trauma 6. comorbid neurological disorder 7. any uncontrolled medical condition 8. pacemaker 9. any condition where fatiguing contractions or resisted leg contractions are contraindicated 10. inability to walk for 5 minute bouts on a treadmill with a harness supporting up to 50% of the body weight at 80% of over-ground self-selected walking speed. Inclusion Criteria (Healthy Control Subjects): 1. be between ages of 18-85 2. be able to give informed consent Exclusion Criteria (Healthy Control Subjects): 1. Those listed above for stroke survivors 2. History of Stroke
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Marquette University
Milwaukee, Wisconsin, 53233, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a checklist and heart monitor stop repeat strokes?
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
- Stroke's hidden heart rhythm clue under investigation
- Zapping the spine while wearing a robotic ankle: a new way to help kids walk?
- Can a nurse and a neighbor help tame chronic disease?
- Can PET scans reveal hidden heart inflammation after a stroke?