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Simple cuff trick may boost walking after stroke

NCT ID NCT04038697

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured walking speed and leg strength to see if this technique could improve mobility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ischemic conditioning (a procedure using a blood pressure cuff to temporarily stop blood flow to the leg)
What this could lead to
If it works, this could offer a simple, non-drug way to help stroke survivors walk faster and improve leg function.
What could go wrong
This is a small, early-stage study with no phase designation, so results may not be conclusive. The procedure is safe but may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Dec 2018

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (Stroke Survivors): 1. be ≥ 1 year post diagnosis of a unilateral, cortical stroke and have residual lower extremity paresis 2. be between the ages of 18-85 3. be able to give informed consent 4. walk slower than normative values based on age and sex Exclusion Criteria (Stroke Survivors): 1. history of deep vein thrombosis or any condition in which transient ischemia to the lower extremity is contraindicated 2. inability to follow 2 step commands 3. chronic low back or hip pain 4. history of substance abuse 5. history of head trauma 6. comorbid neurological disorder 7. any uncontrolled medical condition 8. pacemaker 9. any condition where fatiguing contractions or resisted leg contractions are contraindicated 10. inability to walk for 5 minute bouts on a treadmill with a harness supporting up to 50% of the body weight at 80% of over-ground self-selected walking speed. Inclusion Criteria (Healthy Control Subjects): 1. be between ages of 18-85 2. be able to give informed consent Exclusion Criteria (Healthy Control Subjects): 1. Those listed above for stroke survivors 2. History of Stroke

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Marquette University

    Milwaukee, Wisconsin, 53233, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

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