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New melphalan combo shows promise in Half-Matched transplants for blood cancer patients

NCT ID NCT03159702

First seen Feb 01, 2026 · Last updated Jun 12, 2026 · Updated 24 times

Summary

This study tested a new version of the chemotherapy drug melphalan (EVOMELA) combined with fludarabine and total body irradiation before a half-matched (haploidentical) stem cell transplant in 43 adults with blood cancers like multiple myeloma. The goal was to see if this approach is safe and helps patients live longer without their cancer getting worse. Results showed the treatment was generally safe, with serious side effects monitored, and one-year progression-free survival was evaluated.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Froedtert Hospital & the Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

Conditions

The condition(s) this trial relates to.

hematologic disorder hematopoietic and lymphoid system neoplasm plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.