THYROID CANCER

This early-stage study tests a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors (like melanoma, lung, or colon cancer) that have a specific BRAF gene change and have stopped responding to standard treatments. The drug is given alone or combined w…

This early-phase study tests whether giving two drugs (XL092 and cemiplimab) before surgery can safely help remove anaplastic thyroid cancer completely in people with a specific gene type (BRAF V600E wildtype). About 12 adults with this rare, aggressive cancer will receive the dr…

This early-stage study tests a new drug called SLV-154 in about 70 adults with advanced solid tumors that have spread. The main goal is to find the safest dose and check for side effects. Participants have cancers like head and neck, lung, breast, or ovarian cancer that haven't r…

This study tests a new drug called AL2846 in people with advanced thyroid cancer that no longer responds to radioiodine or previous targeted therapy. The goal is to see if AL2846 can slow cancer growth better than a placebo. About 144 adults will take part in this double-blind, P…

This early-phase trial tests a new drug called MDX2001 in about 285 adults with advanced solid tumors (cancers that have spread). The main goals are to check the drug's safety and find the right dose. Researchers will also see if it shrinks tumors. This is not a cure, but it may …

This study tests two different daily doses (24 mg vs. 10 mg) of the drug lenvatinib in people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. About 34 ad…

This study tests a drug called zanzalintinib given before surgery for people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors and make surgery more effective. About 45 adults with certain types of thyroid cancer will take part. Researchers will also …

This early-stage study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, or related mutations). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. …

This study looks at how well the drug T-DXd works for people with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. About 100 adults in the US will be followed to see if their tumors shrink or stop growing. The goal is to u…

This study tests two drugs together for people with a rare and aggressive type of thyroid cancer (ATC or PDTC) that has spread and cannot be removed by surgery. The drugs, MRG003 and pucotenlimab, are given every three weeks to try to shrink tumors. The goal is to see how well th…

This study tests whether using a special camera that makes parathyroid glands glow (autofluorescence) during thyroid cancer surgery can reduce the risk of hypoparathyroidism, a condition where calcium levels drop. About 160 adults having their thyroid removed for cancer will be r…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control thyroid cancers that have a specific genetic change (RAF dimer-driven) and no longer respond to radioactive iodine. The study includes two groups: one with differentiated thyroid cancer and one…

This study looks at whether adding radiation therapy to the usual radioactive iodine treatment can keep thyroid cancer from returning in people with high-risk, advanced disease. About 124 patients who had surgery but still have some cancer left will be randomly assigned to get ei…

This study looks at whether giving radiation therapy after surgery can help prevent thyroid cancer from coming back in people at high risk. About 80 adults aged 14 to 79 with certain types of thyroid cancer will take part. Researchers will track how long participants stay cancer-…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to shrink or control advanced solid tumors like lung, pancreas, and colorectal cancer. About 54 adults whose cancers hav…

This early-phase study is testing a new radioactive drug called 177Lu-CTR-FAPI in 12 people with thyroid cancer that has spread and is no longer responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow the disease. Th…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study looks at whether closely monitoring small thyroid nodules (under 2 cm) with regular ultrasounds is a safe and effective alternative to immediate surgery. The goal is to avoid unnecessary operations and the need for lifelong thyroid medication. Researchers will follow 1…

This study tests whether a less extensive neck surgery (selective neck dissection) works as well as the standard more extensive surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to a small number of lymph nodes in the side of the neck. Ab…

This study is for people with intermediate-risk differentiated thyroid cancer. It compares two approaches after surgery: giving radioactive iodine (RAI) to everyone, or only giving it based on follow-up tests. The goal is to see if the guided approach works just as well while avo…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study compares a new imaging agent, F-18 TFB, to the standard FDG PET/CT scan for finding thyroid cancer in 50 people who have had surgery and radioactive iodine therapy but still have high thyroglobulin levels. F-18 TFB targets thyroid cells specifically, potentially offeri…

This study tests whether a newer type of PET scan (I-124 PET/CT) is better at finding thyroid cancer that has spread than the usual imaging methods (I-123 and I-131 scans). About 62 people with thyroid cancer will get both scans, and doctors will compare the results. The goal is …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study tests whether using artificial tears right after radioactive iodine therapy can prevent tear duct blockages in thyroid cancer patients. Radioactive iodine can get into tears and damage the tear ducts, causing blockages over time. The trial will follow 100 adults for tw…

This study tests a decision-support tool that uses early blood tests to predict the best dose of levothyroxine (thyroid hormone) after thyroid removal. Normally, finding the right dose takes months of trial and error. The tool aims to get patients to the correct dose faster, whic…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether a special mushroom powder (Ganoderma lucidum spores) can reduce depression in women who have had thyroid cancer surgery. Three hundred female participants will take either the mushroom supplement or a placebo for three months. The goal is to see if it imp…

This study reviews 600 patients' records over 10 years to find out why some people develop low calcium levels after thyroid removal. Low calcium is a common complication, affecting up to half of patients. The goal is to identify risk factors so doctors can better predict, prevent…

This study is creating a large database of medical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid cancer, prostate cancer, or neuroendocrine tumors. The goal is to provide researchers with valuable data to better understand these treatm…

This study tests whether a special decision aid website helps people with intermediate-risk thyroid cancer make informed choices about radioactive iodine (RAI) treatment. About 408 participants will be randomly assigned to use either the decision aid or a standard information web…

This study is testing new MRI techniques to get more detailed information about head and neck and thyroid tumors. Researchers will compare these new scans with standard follow-up data to see if they can better predict how a tumor responds to treatment. The study involves 200 adul…

This study collects real-world data from 459 adults with advanced thyroid cancer (anaplastic or poorly differentiated) who cannot join traditional clinical trials. Researchers aim to understand barriers to treatment access and how patients tolerate and respond to standard medicat…

This study tests two methods of preparing patients with advanced thyroid cancer for a special PET scan that helps plan radiation treatment. Thirty participants will receive both a hormone injection and thyroid hormone withdrawal to see which method better predicts the right radia…

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study aims to create and test a new scoring system (RTAS) to evaluate how well surgeons perform robotic thyroidectomy. Researchers will enroll 200 people with thyroid cancer or benign thyroid nodules who are having robotic surgery. The goal is to improve surgical training an…

This study aims to improve and test a prediction model that helps doctors know how difficult a thyroid surgery through the mouth or chin will be. Researchers will enroll 300 people with thyroid cancer or benign nodules. The goal is to make surgery safer and create better training…

This study looks at how things in the environment, like chemicals, might affect thyroid cancer. Researchers will collect small blood samples and have participants fill out questionnaires to find links between exposures and cancer outcomes. The goal is to understand why some thyro…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is watching 120 people with advanced thyroid cancer to see how their tumors respond to treatment given before surgery. Researchers will measure changes in tumor size on scans, check cancer markers in the blood, and look at removed tissue under a microscope. The goal is…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) or active monitoring with regular ultrasounds. The goal is to see if monitoring causes less anxiety and maintains quality of life. Twenty adults…

This study aims to learn more about how to diagnose and treat thyroid nodules and thyroid cancer. It will involve up to 2,500 people who have or may have these conditions, as well as family members at genetic risk. Participants will undergo standard medical tests like blood draws…

This study looks at why some thyroid nodule biopsy samples are not good enough for diagnosis. Researchers will collect samples from 160 people and check factors like needle size and technique. The goal is to reduce the need for repeat biopsies, which can be uncomfortable and cost…

This study is collecting information from 100 adults with a type of thyroid cancer that does not respond to standard radioactive iodine treatment. Doctors are using special medications called redifferentiating agents to try to make the cancer respond to radioactive iodine again. …

This study follows 500 people who had partial or total thyroid removal for thyroid cancer. Researchers will track symptoms and quality of life using a special questionnaire. The goal is to learn how patients feel after surgery to improve future care. No new treatments are being t…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can prevent drug-related problems. TRT uses radioactive drugs to kill cancer cells while sparing healthy tissue. The study will inc…

This study looks at how changing thyroid hormone levels impact the way the body uses sugar and fat. Researchers will measure insulin sensitivity and energy use in 60 people with Graves' disease or thyroid cancer before and after their hormone levels are adjusted. The goal is to b…

This study is testing a special collar worn around the neck that measures how the body processes radioactive iodine used to treat thyroid cancer and Graves disease. The goal is to see if this device can give doctors better information to personalize the dose for each patient, pot…