THYROID CANCER

This study tests the drug vemurafenib in 24 people with advanced papillary thyroid cancer that has a BRAF gene mutation. The goal is to see if the drug can shrink tumors or change certain markers in the blood and tissue before surgery. Participants take the drug for 56 days, and …

This study looks at people with low-risk papillary thyroid cancer (tumors 11-40 mm). It compares two surgeries: removing the thyroid alone versus removing the thyroid plus nearby lymph nodes in the neck. The goal is to see if the extra lymph node removal leads to better remission…

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This study tested a targeted therapy called regorafenib in 8 people with advanced medullary thyroid cancer that had spread. The goal was to see if the drug could slow or stop cancer growth. Participants had already tried other treatments before joining.

This study tests the drug pembrolizumab (Keytruda) in 12 people with advanced anaplastic thyroid cancer that cannot be cured by standard treatments. The goal is to see if the drug can shrink or stop the cancer. Participants receive the drug every 3 weeks until the cancer worsens …

This study tests a combination of two drugs—pembrolizumab (an immunotherapy) and docetaxel (chemotherapy)—in people with advanced thyroid or salivary gland cancers that are not responding to standard treatments. The goal is to see if the combo can shrink tumors and help patients …

This study looks at whether low risk thyroid cancer patients need radio-iodine treatment after having their thyroid removed. About 504 participants will be followed to see if skipping this treatment affects cancer recurrence or survival. The goal is to find out if some patients c…

This study tests whether a drug called PDR001, combined with either trametinib or dabrafenib, is safe and effective for people with thyroid cancer that no longer responds to standard radioactive iodine treatment. The trial enrolled 19 adults whose cancer had worsened. The main go…

This early study tests whether a laser inserted through the skin can safely destroy small thyroid cancers without surgery. Ten adults with papillary thyroid microcarcinoma (tumors 13 mm or smaller) will receive the laser treatment, then have the treated area removed six months la…

This study aims to validate a microRNA signature that could better classify thyroid nodules with uncertain results from standard needle biopsies. Researchers will compare the test results with ultrasound and final surgical tissue analysis in 71 adults. If successful, this approac…

This study tests a new way to take pictures of thyroid cancer and nearby lymph nodes using Cerenkov luminescence, a type of light produced during certain medical treatments. About 102 adults with thyroid cancer or other tumors will be imaged after routine scans or therapy. The go…

This study tests whether an artificial intelligence (AI) tool can help doctors read thyroid ultrasounds more accurately and quickly. About 2,000 adults with suspected thyroid problems will have their ultrasound images analyzed by both doctors and the AI. The goal is to see if the…

This study looks at whether proteins found in urine can help doctors tell if a thyroid growth is cancerous before surgery. Currently, the only way to diagnose follicular thyroid cancer is to remove the nodule and examine it under a microscope. Researchers are testing urine sample…

This study looks at whether a nerve block given during thyroid surgery can lower the body's stress response, as measured by stress markers in blood and saliva. 48 adults having their thyroid removed will be split into two groups: one gets standard anesthesia, the other gets the s…

This study follows 107 thyroid cancer patients to see how their metabolism differs when they prepare for radioiodine therapy using either Thyrogen injections or by temporarily stopping their thyroid medication (Eltroxin). Researchers will measure depression symptoms, body composi…

This study looks at 5000 adults who had a thyroid nodule found on a PET-CT scan. It compares those who had a follow-up thyroid ultrasound within 3 months to those who did not. The goal is to see if skipping the ultrasound leads to a higher risk of death over 7 years. The research…

This study explores whether the way thyroid cancer patients prepare for a radioactive iodine scan affects how much iodine is taken up by breast tissue. Researchers will measure prolactin levels and compare two preparation methods: stopping thyroid hormone or using a synthetic hor…

This study was designed to see if thyroid surgery changes the thickness of the carotid artery, a marker for heart disease and stroke risk. It planned to follow patients before and after surgery, measuring artery thickness and tracking heart events. However, the study was withdraw…

This study tests whether an artificial intelligence (AI) tool can help medical students and doctors more accurately stage thyroid cancer and assess risk. About 70 participants will review patient notes, some with AI help and some without. The goal is to see if the AI assistant im…

This study explores whether substances found in urine can help doctors track thyroid cancer after treatment. Researchers are measuring specific proteins in the urine of 103 patients who had their thyroid removed. The goal is to find a simple, non-invasive way to monitor the disea…