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Laser zaps tiny thyroid tumors, no scalpel needed

NCT ID NCT04623801

Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This early study tests if a laser can safely destroy small thyroid cancers (papillary thyroid microcarcinoma) without removing the thyroid. Ten adults with small tumors will receive laser treatment, then have their thyroid removed 6 months later to check if the cancer is fully gone. The goal is to see if this less invasive option works as well as surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2020

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Papillary thyroid cancer documented by * (a) Bethesda VI cytology, * (b) Bethesda III, IV, V, or VI cytology AND BRAF V600E mutation, or * (c) Bethesda V cytology AND high risk ultrasonographic features documented by either the ATA high suspicion or TIRADS 5 nodule characteristics To ensure the majority of cases will be eligible based on criteria (a) or (b), we will enroll ≤ 2 patients based on criteria (c). * Maximum diameter ≤ 13 mm * Declined active surveillance * The thyroid lesion must be primarily solid with ≤ 25% cystic compent * No US evidence of extrathyroidal extension through the thyroid capsule * No imaging evidence of lymph node metastasis * Preserved contralateral vocal cord function prior to PLA Exclusion Criteria: * Thyroid cancer that is non papillary thyroid cancer (PTC) * Thyroid lesion with \> 25% cystic component * Lesion with US evidence of extrathyroidal extension through the thyroid capsule * Clinical or ultrasonographic evidence of lymph node metastasis * Pregnancy

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Conditions

The condition(s) this trial relates to.

papillary thyroid Microcarcinoma thyroid cancer thyroid gland disorder Thyroid Neoplasms thyroid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Papillary thyroid microcarcinoma Thyroid Thyroid cancer

Contacts and locations

Locations

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

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