PERIPHERAL ARTERIAL DISEASE

This study looked at how the blood thinner rivaroxaban, taken with aspirin, affects blood clots and blood vessel health in people with peripheral artery disease (PAD). Sixty adults with PAD took part. Researchers measured blood vessel function and platelet activity to see if the …

This study tested a device called AURYON that removes plaque from leg arteries in 102 people with peripheral artery disease (PAD). The goal was to see how well it opens blocked arteries and if it causes serious problems like bleeding or amputation. The device was used during a pr…

This study tested a new tool called the Kaitoh Atherectomy System to remove blockages in the leg arteries of people with peripheral arterial disease. Nine adults with moderate to severe symptoms took part. The goal was to see if the device is safe and works well at opening the ar…

This study tested a new stent (Dynetic-35) to treat blockages in the iliac arteries of the leg, but placed it through the wrist instead of the groin. Twenty-five people with peripheral artery disease took part, and researchers checked for safety issues like bleeding or stroke, an…

This study tested a temporary stent designed to open blocked arteries below the knee in 130 people with severe leg artery disease. The goal was to improve blood flow and prevent major complications like amputation or death within 30 days. The stent is removed after the procedure,…

This study tested whether adding cilostazol to the standard statin drug rosuvastatin helps people with chronic leg artery disease (peripheral artery disease) feel better and walk farther. About 260 adults with stable leg symptoms for at least 6 months took either the combo or ros…

This study looked at different treatments for people whose leg artery stents became completely blocked. It included 322 adults with severe leg pain or wounds. The goal was to see how well the treatments restored blood flow and how long they lasted without needing another procedur…

This study tested a special vacuum dressing called Prevena placed on groin incisions during vascular surgery to see if it lowers wound complications like infection, reopening, or fluid buildup. The trial involved 140 high-risk patients having femoral incisions for artery repair o…

This study tested a two-step treatment for people with severe calcium buildup in their leg arteries. First, a shockwave device breaks up the hard plaque, then a drug-coated stent is placed to keep the artery open. The goal was to see if this combination is safe and effective at k…

This study tested whether a structured education program, called the 'Critical Limb Ischemia School,' helps patients with severe leg artery disease. The program teaches about the condition, lifestyle changes like quitting smoking and exercise, and when to seek help. Researchers c…

This pilot study tested whether delivering the drug paclitaxel directly to the artery wall during a standard leg artery procedure could help keep the artery from narrowing again. 27 adults with leg pain from blocked arteries took part. The goal was to see if this approach improve…

This study tested a new tool called the AngioSafe Peripheral CTO Crossing System in 79 people with blocked leg arteries (peripheral artery disease). The device helps doctors guide a thin wire through the blockage to restore blood flow. The main goal was to see if the device is sa…

This study tested whether injecting donor stem cells into the leg muscles of people undergoing major leg amputation could prevent wound complications and reduce the need for further amputations. 81 adults aged 40-90 with severe artery disease received stem cell injections above a…

This study tested a new device called the PQ Bypass Stent Graft System in 60 people with peripheral artery disease (PAD) who had long blockages in their leg arteries. The goal was to see if the device could safely open the artery and keep it open for at least 12 months. The study…

This study tested a special balloon coated with sirolimus, a drug that helps keep arteries open, in 34 people with peripheral artery disease (blocked leg arteries). The goal was to see if the balloon is safe and works well at preventing the artery from narrowing again after treat…

This study tested a special stent (a small mesh tube) called LifeStream in 70 people with severe blockages in the main leg arteries. The goal was to see if the stent could keep the artery open and prevent serious problems. Participants were followed for up to 5 years after the pr…

This study looked at how well simple bedside tests (like using a Doppler device or checking blood pressure in the ankle and toe) can detect poor leg circulation in people with diabetes. Poor circulation is a major cause of leg amputations in diabetes. The study involved 604 adult…

This study tested whether adding body awareness therapy (gentle exercises focusing on breathing, relaxation, and body awareness) to a standard exercise program could improve walking ability, pain, and emotional well-being in people with peripheral artery disease (PAD). 51 adults …

This study looked at whether a small device called TENS, which uses gentle electrical pulses to block pain, can help people with leg pain from narrowed arteries walk more and feel better. About 95 adults with stable leg pain on walking took part. The goal was to see if a larger f…

This study looked at whether taking creatine supplements and doing muscle stretching exercises could help people with peripheral artery disease (PAD) walk longer distances. PAD causes leg pain due to poor blood flow. Thirteen adults with PAD took part in a 4-week program of stret…

This study tested a hybrid rehabilitation program for people with peripheral arterial disease (PAD), a condition that causes leg pain and makes walking hard. 26 participants started with a few on-site classes and then continued a walking program at home. The goal was to see if th…

This study tested whether deep breathing exercises can reduce pain and help stabilize heart rate and blood pressure in people who just had a procedure to open blocked leg arteries. 100 adults took part, with half doing the breathing exercises and half receiving standard care. The…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to me…

This study looked at whether patients who had a heart attack, stroke, or other blood vessel problems were prescribed the right cholesterol-lowering medicine when they left the hospital. The goal was to see how well doctors followed official guidelines. 129 patients were included,…

This study looked at 61 adults with peripheral artery disease to see if gum health affects levels of TMAO, a chemical linked to heart problems. Researchers measured TMAO in blood and saliva and compared people with healthy gums, gum disease, or no teeth. The goal was to understan…

This study looked at over 26,000 adults who had vascular procedures (like treating blocked arteries or varicose veins) in a doctor's office instead of a hospital. The goal was to see how often people went home safely versus needing emergency care or hospital admission. The result…

This study looked at a small molecule called microRNA-210 in 230 people with peripheral artery disease (PAD), a condition that causes leg pain and poor blood flow. Researchers measured the molecule's levels in calf muscle samples and tested how far participants could walk. The go…

This study tested a type of motorized shoe (exoskeleton footwear) to see if it helps people over 40 with and without peripheral artery disease walk more easily. Researchers measured how the shoes affected walking mechanics, muscle oxygen, and energy use. The goal was to find the …

This study looked at how arm exercise changes oxygen levels in the leg muscles of people with peripheral artery disease (PAD), a condition that causes leg pain during walking. Researchers measured oxygen saturation in the calf using a light-based sensor while 26 participants exer…

This study tested a special type of scan (SPECT/CT) to measure blood flow in leg muscles. Researchers compared healthy people to those with peripheral artery disease (PAD) and diabetes. They also used the scan to see if blood flow improved after a procedure to open blocked leg ar…

This study followed nearly 800 people with peripheral artery disease (PAD) for one year to learn how the condition affects their symptoms, daily function, and quality of life. Researchers tracked treatments and health outcomes to find gaps in care and differences based on age, ge…

This study looked at whether using telemedicine (video or phone calls) helps people with hard-to-heal leg wounds in rural areas see a specialist faster than going in person. About 116 adults with leg ulcers from conditions like diabetes or poor blood flow took part. Researchers m…

This study tested a tool called KomPas+ that helps physical therapists and patients with intermittent claudication (leg pain from blocked arteries) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of l…

This study looked at how arm cranking exercise changes blood flow in the leg arteries of people with peripheral artery disease (PAD). Fifteen participants with PAD and leg pain during walking did three different sessions: arm exercise, warm water foot soaking, and rest. Researche…