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Creatine and stretching: a new hope for leg pain?

NCT ID NCT04471792

Symptom relief Sponsor: Florida State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small Phase 2 trial tested whether taking creatine supplements combined with a muscle-stretching device could help people with peripheral artery disease (PAD) walk longer. Thirteen participants either received creatine plus stretching or a placebo (cellulose) plus stretching for four weeks. The main goal was to see if walking distance improved in a six-minute walk test. The study also measured muscle oxygen levels using special imaging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Creatine monohydrate
What this could lead to
If it works, this could point toward a simple, low-cost way to improve walking ability in people with peripheral artery disease.
What could go wrong
This is a very small, early-phase trial with only 13 participants. Results may not apply to everyone, and the benefits of creatine for this condition are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

13 people

The number who actually took part.

Started

May 2020

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 95 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Ankle-brachial index (ABI) of 0.90 or less in either leg or clinical diagnosis by a medical doctor (PAD group only) 2. Stable condition for at least 3 months (PAD group only) Exclusion Criteria: 1. Habitual exercise or cardiovascular rehabilitation program during the past 3 months 2. Critical limb ischemia 3. Blow or above-knee amputation 4. Leg pain at rest 5. Major surgery or lower extremity revascularization in the last 3 months 6. Major medical illness treatment during the prior 12 months 7. Central neurological disease 8. Limited ankle or knee joint range of motion 9. Requirement of oxygen with activity or exercise 10. Heart failure 11. Atrial fibrillation 12. Wheelchair confinement or inability to walk 13. Cognitive disorder 14. Vasculitis problems including Takayasu's arteritis, Berger's disease, collagen disease or Reynaud's disease 15. Overt cardiovascular disease 16. Metabolic disease 17. Renal disease

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peripheral arterial disease

Contacts and locations

Locations

  • Florida State University

    Tallahassee, Florida, 32304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.