PERIPHERAL ARTERIAL DISEASE

This study tests a new stem cell treatment for people with severe leg artery disease and hard-to-heal ulcers. Researchers will take a small amount of fat tissue from each patient, grow stem cells from it, and inject them around the wound. They will also apply a special stem-cell …

This study tests whether using a special device (Auryon Atherectomy System) along with standard balloon angioplasty is safer and more effective than balloon angioplasty alone for clearing blockages in the lower leg arteries. About 50 people with severe peripheral artery disease (…

This study tests a special balloon coated with medicine to open up blocked arteries in the legs caused by cholesterol buildup. The balloon is longer than standard ones, allowing it to treat larger blockages in one go. About 200 adults with narrowed or blocked leg arteries will re…

This study tests a new drug called etrinabdione in 30 adults with peripheral arterial disease (PAD), a condition where leg arteries narrow, causing pain while walking. Participants take the drug twice daily for 12 months to see if it is safe and if it improves blood flow and walk…

This study tests whether a special camera that uses near-infrared light can measure oxygen levels in leg tissues to help diagnose peripheral artery disease (PAD). Researchers will compare these light measurements with standard tests in 200 adults with known or suspected PAD. The …

This study tests whether using a virtual reality headset during leg artery surgery can lower pain and anxiety. About 90 adults with peripheral artery disease will either receive standard care or add VR during the procedure. The goal is to find a non-drug way to make the surgery m…

This study compares a hybrid cardiac rehabilitation program (center sessions plus home telerehabilitation) to standard supervised exercise for 40 adults aged 50-70 with peripheral artery disease. The goal is to see if the hybrid approach improves walking distance, reduces leg pai…

This study looks at whether a CT scan already done for routine care can predict which patients with leg artery disease will improve with supervised exercise. About 40% of patients don't get enough benefit from exercise and need a procedure to open blocked arteries. Researchers wi…

This study looks at whether two common blood thinners, aspirin and clopidogrel, can lower certain signs of inflammation in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure how these drugs affect clusters of blood cells that…

This study tests whether a special dye, called LUMISIGHT, can make inflammation in artery plaques visible after they are removed during surgery. Inflammation is a key driver of heart attacks and peripheral artery disease, but doctors currently lack a way to see it clearly. The st…

This study aims to develop artificial intelligence tools that can predict how blood vessel diseases like abdominal aortic aneurysm and peripheral arterial disease will progress. Researchers will collect data from 1100 participants across Europe, including medical records, blood s…