PERIPHERAL ARTERIAL DISEASE

This study looks at whether doing a simple handgrip exercise for 12 weeks can lower blood pressure in people with peripheral artery disease (PAD). Researchers will split 30 participants into two groups: one that does the handgrip training and one that just gets encouragement to b…

This study is checking how well a special balloon coated with medicine works for people with blocked arteries in their legs. About 284 participants will get the balloon treatment during routine care. The goal is to see if it safely opens the artery and keeps it open, reducing the…

This study tests whether colchicine, an anti-inflammatory drug used for gout, can reduce the risk of major heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either low-dose colchicine or a place…

This study tests a new balloon coated with everolimus to open blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to receive either the new balloon or a standard paclitaxel-coated balloon. The goal is to see if the new b…

This study tests whether using a special shockwave device to break up calcium in leg arteries works better than standard balloon angioplasty before placing a stent. About 120 people with severe peripheral artery disease and hardened blockages will be randomly assigned to one of t…

This study is testing a special drug-coated stent called ZENFLEX Pro™ to treat blocked arteries in the leg. About 153 people with leg pain or sores from poor blood flow will get the stent and be checked at 1, 6, and 12 months. The main goal is to see if the artery stays open afte…

This study follows 1000 people who received Advanta VXT or Flixene grafts to repair or replace blocked leg arteries. Researchers will track how well the grafts stay open and how often serious problems like amputation or repeat surgery occur over at least 3 years. The goal is to c…

This study looks at whether taking two blood thinners for 6 months after leg artery surgery is better than taking them for just 1 month for people with peripheral artery disease. The goal is to see if the longer treatment keeps the treated artery open longer without causing more …

This study tests whether a new type of stent (GORE VBX) works better than standard metal stents for people with blocked arteries in the pelvis (iliac arteries). About 244 adults with leg pain or tissue loss due to poor blood flow will be randomly assigned to receive either the ne…

This study tests a special balloon coated with medication to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 participants will be randomly assigned to receive either the drug-coated balloon or a standard balloon. The…

This study tests a stem cell product called Stempeucel in 10 Malaysian adults with critical limb ischemia, a severe form of peripheral artery disease that causes pain and ulcers. The treatment is injected into the leg muscles to see if it can reduce pain, heal wounds, improve blo…

This study is testing a device that uses sound waves (shockwaves) to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help patients walk better. About 50 participants will be followed for on…

This study tests whether using ultrasound imaging inside blood vessels during minimally invasive leg artery procedures leads to better outcomes for people with peripheral artery disease. About 350 adults with symptoms like leg pain or wounds will take part. The goal is to see if …

This study tests a new drug called SRSD107 in people with long-term heart or artery disease. The goal is to see if it safely lowers a protein linked to blood clots, which could reduce the risk of heart attacks or strokes. About 104 adults will receive either the drug or a placebo…

This study tests a new procedure that uses a vein to reroute blood flow in people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. About 100 participants will receive the LimFlow System treatment. The main …

This study is testing a new tool called the Golazo system to safely remove plaque from leg arteries in 159 people with peripheral artery disease (PAD). Participants must have symptoms like leg pain or wounds and meet specific blood flow criteria. The goal is to see if the device …

This study tests two ways to help people with peripheral artery disease (PAD) walk farther and with less pain. It compares supervised treadmill exercise versus home walking, with or without nitrate-rich beetroot juice. The goal is to find a more convenient and effective treatment…

This study tests a new procedure that reroutes blood flow in the foot to save the leg from amputation. It is for people with severe leg artery disease who have no other treatment options. The study will check if the procedure is safe and works well in 50 participants.

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries (peripheral artery disease). The scaffold is placed inside the artery to hold it open and improve blood flow. The goal is to see if it is safe and works well …

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests a special catheter that uses sound waves (shockwaves) to break up calcium buildup in the leg arteries. This makes it easier for doctors to place a large stent in the aorta to treat aortic disease. The study will include 40 adults with severely calcified arteries …

This study looks back at medical records of up to 500 people who had a procedure using the Pounce Thrombectomy System to remove blood clots from arteries in the legs. The goal is to see how well the device restores blood flow and how safe it is. Participants are adults who alread…

This study aims to develop a new, noninvasive ultrasound method to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare this ultrasound technique to standard tests in 400 adults with and without PAD symptoms. If successful, it could offer a s…

This study is testing a type of exercise called Blood Flow Restriction (BFR) training in 81 adults with peripheral arterial disease (PAD), a condition that causes leg pain when walking. The goal is to see if BFR training improves walking distance, quality of life, and is safe com…

This study tests a once-daily pill called orforglipron in 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed for abo…

This study tests if using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatment. Th…

This study tests whether taking MitoQ for six months can improve walking ability and reduce leg pain in people with peripheral artery disease. Researchers will measure walking distance on a treadmill and during a 6-minute walk, as well as daily activity and quality of life. The s…

This study tests whether a single dose of the drug diroximel fumarate (Vumerity) can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to poor blood flow. Researchers will give 20 participants …

This early-stage study tests whether fisetin, a compound found in fruits, can reduce aging-related cells in the body and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will take fisetin or a placebo for several months, and researc…

This study tests whether a spinal cord stimulator can reduce leg pain and improve quality of life in people with type 2 diabetes, painful nerve damage, and peripheral artery disease. Fifteen adults who already have a spinal cord stimulator will receive two weeks of active stimula…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study tests whether a fuzzy compression sock can help wounds heal faster after a leg amputation due to poor blood flow. About 40 adults will either get the special sock or standard care. Researchers will track infections, pain, and how soon a prosthetic leg can be fitted.

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated. The goal is to confirm the device is safe and works as intended.

This study compares two methods—road mapping and ultrasound—for guiding a needle into a leg artery during a procedure to open blocked vessels. It includes 32 adults with severe leg artery disease who need this approach. The goal is to see which method is safer and more successful…

This study checks if a simple leg strength test done over a video call gives the same results as doing it in person for people with peripheral artery disease (PAD). About 45 adults with PAD will do the 30-second sit-to-stand test both ways. If reliable, it could allow remote moni…

This study is watching 14,000 people with peripheral artery disease (PAD) to see how well stents work compared to treatments without stents. Researchers will track things like repeat procedures, amputations, and walking ability for one year. The goal is to learn which approach wo…

This study aims to understand how inflammation, calcium buildup, and blood clots behave in the arteries of people with peripheral artery disease (PAD). Researchers will use special PET scans to take detailed pictures of these processes in the legs and other parts of the body. Abo…

This study looks at whether a passive leg-paddling motion (LEAP therapy) during 2.5 hours of sitting can improve blood flow and walking ability in people with peripheral artery disease (PAD) and in healthy older adults. About 24 participants will each try both sitting with LEAP t…

This study looks at how your fitness level relates to the bacteria in your mouth and how well blood flows to your muscles. Researchers will collect mouth swabs, saliva, and have participants do a cycling test. The goal is to understand these connections in people with heart failu…