PERIPHERAL ARTERIAL DISEASE

This study is testing whether a balloon coated with the drug sirolimus works better than a standard balloon for opening blocked arteries in the legs. It aims to see if the coated balloon can reduce the need for future surgeries or major leg amputations in 1,200 patients with seve…

This study is testing a medical device called SWM-831 to treat severely hardened leg arteries in people with peripheral artery disease. The device is used to open up blocked arteries before placing a drug-coated balloon or stent. Researchers are enrolling up to 81 patients in Jap…

This study is testing whether adding a small metal mesh tube (stent) to a standard artery-opening procedure works better than the procedure alone for people with severe leg artery disease. Researchers are comparing two approaches in 177 participants with poor blood flow to their …

This study is observing how well a small, already-approved stent works for people with severe blockages in the arteries below the knee. It will follow 300 patients who have received the MicroStent to see if it keeps the arteries open, helps wounds heal, and prevents major amputat…

This study is testing a special balloon coated with a drug (Legflow DCB) against a standard balloon to see which is better at treating narrowed or blocked arteries in the thigh and knee. It involves 150 adults with painful leg cramps when walking due to poor circulation. The main…

This study is testing a new type of balloon coated with a drug (sirolimus) to see if it works better than a standard balloon at keeping leg arteries open. It involves 300 people with narrowed or blocked arteries in their upper leg, which can cause pain and difficulty walking. The…

This study is testing if adding a low dose of the blood thinner rivaroxaban to standard aspirin therapy helps improve blood vessel health and reduce harmful blood clotting in people with peripheral artery disease (PAD). Researchers are enrolling 75 adults with PAD to see if the d…

This study aimed to test if a new measurement of tiny blood vessel function could predict whether a patient's leg could be saved after a procedure to open blocked arteries. It focused on patients with severe leg artery disease who were at high risk of amputation. The goal was to …

This study aims to better understand critical limb ischemia, a severe form of leg artery disease that causes extreme pain, poor wound healing, and high risk of amputation and death. Researchers are observing 458 patients to document their symptoms, current treatments, and outcome…