PERIPHERAL ARTERIAL DISEASE

This study tests a new stent (MicroStent) for people with severe artery blockages below the knee that cause pain or wounds. About 177 adults with critical limb ischemia will either get the stent plus balloon angioplasty or balloon angioplasty alone. The goal is to see if the sten…

This study tests a special balloon coated with a drug (SELUTION SLR™ 018) to treat blocked arteries in the leg caused by peripheral artery disease (PAD). About 300 people will be randomly assigned to receive either the drug-coated balloon or a standard uncoated balloon. The goal …

This study is tracking how well the DETOUR system works in everyday medical practice for people with long blockages or severe narrowing in the leg arteries. About 450 participants who are not good candidates for surgery or other less invasive treatments will be enrolled. The main…

This study aimed to see if injections of cells from the placenta could improve blood flow and help heal foot ulcers in people with diabetes and peripheral artery disease. It was planned for about 24 adults with hard-to-heal ulcers. However, the study was withdrawn before any part…

This study tests two approaches for treating complex blockages in the leg's main artery. One group gets a drug-coated balloon to open the artery without leaving a permanent stent, while the other group gets a stent. The goal is to see which method keeps the artery open longer and…

This study looks at how well a stent called MicroStent works in people with narrowed leg arteries (peripheral artery disease). Researchers are tracking 300 patients to see if the stent keeps arteries open and prevents serious problems like amputation or the need for another proce…

This study tests a device called SWM-831 in 81 people with moderate to severe hardening of the leg arteries (peripheral arterial disease). The device is used before balloon or stent placement to break up calcium blockages. The main goal is to see if it can successfully open the a…

This study compares a balloon coated with sirolimus, a drug that helps keep arteries open, to a standard balloon in 1,200 people with peripheral artery disease (PAD) in the leg. The goal is to see if the coated balloon is as good or better at preventing major problems like unplan…

This study compares a special balloon coated with a drug (Legflow DCB) to a standard balloon for opening blocked leg arteries in people with peripheral artery disease. About 150 adults with leg pain or sores will be treated and followed for a year to see if the drug-coated balloo…

This study follows 500 people with peripheral artery disease (narrowed leg arteries) who undergo a procedure to restore blood flow. Researchers check blood for heart-damage markers and use heart ultrasound to find silent injuries that may raise future heart attack or stroke risk.…

This research project tracks the experiences of 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to gather information to set new standards for diagnosing the condition, measure what matters mo…

This study aimed to see if a new way to measure blood flow in tiny leg vessels could predict whether a leg can be saved after treatment for severe artery disease. It was planned for adults with critical limb ischemia who had already undergone a procedure to open blocked arteries.…

This study looks at how arm crank exercise (like pedaling with your arms) changes blood vessel function in people with peripheral artery disease (PAD) compared to healthy individuals. Researchers will measure blood flow and oxygen levels in the leg muscles before and after exerci…