OBSTRUCTIVE SLEEP APNEA

This study compares two treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine. One treatment is a custom mouthpiece that moves the jaw forward, and the other is a surgically implanted device that stimulates a nerve to keep the airway op…

This study tests a program that combines motivational interviewing with text messages to help Native American elders (age 50+) with sleep apnea use their breathing machine more regularly. Better use of the machine may improve sleep and lower the risk of memory problems. About 300…

This study tests a custom mouthpiece called OrthoApnea NOA for people with obstructive sleep apnea who struggle with CPAP machines. Researchers will compare new users to past patients using other mouthpieces to see if the NOA cuts breathing pauses by at least half. The study also…

This study tests whether brief, mild low-oxygen breathing sessions can improve heart health and reduce fatigue in people with obstructive sleep apnea. About 60 adults aged 30-60 with untreated sleep apnea will receive the treatment or a placebo. The goal is to see if this approac…

This study tests whether a personalized surgical approach, guided by a sleep endoscopy, works better than standard tonsillectomy for children aged 2-17 with sleep apnea and small tonsils. About 240 children will be randomly assigned to one of the two surgeries. The goal is to see…

This study follows 225 adults with moderate-to-severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulation implant. The device is for people who cannot use or tolerate CPAP machines. Researchers will track how well the implant reduces breathing pauses dur…

This study compares personalized surgery guided by a sleep endoscopy to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and often doesn't improve with standard treatments. T…

This study looks at whether finding and treating obstructive sleep apnea can help people with atrial fibrillation (an irregular heartbeat). About 209 adults with AF will use a home sleep test and a Fitbit smartwatch to track their heart rhythm. If sleep apnea is found, they will …

This study tests a new drug, maridebart cafraglutide, to see if it can reduce breathing pauses during sleep in adults with obstructive sleep apnea who are overweight or obese and not using a CPAP machine. About 250 participants will receive either the drug or a placebo for 52 wee…

This study tests whether a cheap, once-daily pill called acetazolamide can help people with obstructive sleep apnea who cannot tolerate a CPAP mask. Sixty adults with moderate to severe sleep apnea will receive either the drug or a placebo for 4 weeks each. The goal is to see if …

This study looks at how well a nerve-stimulation therapy works for Latin American adults with moderate-to-severe obstructive sleep apnea. Researchers will examine the upper airway and compare responses to earlier US studies. About 50 participants will be enrolled to see if this t…

This study tests a custom mouthpiece (EVO device) in 49 adults with severe obstructive sleep apnea. The device moves the jaw forward to keep the airway open during sleep. Researchers will check if it reduces breathing pauses by at least half and keeps them below a safe level afte…

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This early study tests a new magnetic device (Magnap) for obstructive sleep apnea. It involves a small implant and an external brace to keep the airway open during sleep. The study includes 10 adults who cannot tolerate CPAP therapy and aims to see if the device is safe and usabl…

This study tests a new, smarter algorithm for CPAP machines that automatically adjusts air pressure to treat obstructive sleep apnea. About 80 adults who already use a ResMed CPAP will try the new algorithm for up to 8 weeks. Researchers will check if the new algorithm reduces br…

This study tests if a smartphone app called SmartWell24 can help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. Researchers will track CPAP usage and quality of life in 40 adults newly diagnosed with sleep apnea. The goal…

This study compares how satisfied people are with two different CPAP machines for treating moderate to severe obstructive sleep apnea. Fifty adults who have not used CPAP before will try both a standard home machine and a smaller portable one. The goal is to see which device user…

This study tests whether using a PAP machine (a device that helps keep airways open during sleep) can improve recovery in people who have had a stroke and also have moderate to severe sleep apnea. About 360 participants will be randomly assigned to receive PAP therapy or usual ca…

This study tests a new device called DidgeriTU for people with mild-to-moderate obstructive sleep apnea. The goal is to see if it reduces breathing pauses during sleep better than a fake device. Participants will use the device daily for 3 months and complete sleep tests and ques…

This study tests whether dronabinol, a drug similar to a compound in marijuana, can help people with obstructive sleep apnea. About 120 adults with moderate to severe sleep apnea will take the drug by mouth for two weeks. Sleep tests before and after treatment will measure if bre…

This study looks at whether lifestyle changes can help lower eye pressure in people who have both glaucoma and obstructive sleep apnea. Researchers will track 40 participants and measure changes in eye pressure, sleep quality, and body measurements. The goal is to see if simple d…

This study tests a special nasal device (ssNPA) to see if it can help children with weak throat muscles breathe easier during sleep. About 40 children with obstructive sleep apnea will try the device overnight. The goal is to reduce breathing pauses and improve sleep quality, wit…

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with sleep apnea over 3 months. The goal is to see if raising th…

This study tests whether doing simple mouth and throat exercises can help people with obstructive sleep apnea who cannot tolerate the standard CPAP machine. 45 adults will be randomly assigned to supervised, unsupervised, or fake exercises for 10 weeks. The main goal is to see if…

This study tests if a custom mouthpiece (mandibular advancement device) can safely and effectively treat severe sleep apnea in 30 adults who cannot use CPAP and whose nerve stimulation therapy did not work. Participants will use the mouthpiece at night and take home sleep tests t…

This study tests whether a couple-focused mobile health program helps people with sleep apnea use their CPAP machine more consistently. About 360 newly diagnosed patients and their partners will receive supportive resources on their phones for six months. The goal is to improve C…

This study tests whether community health workers can help people with moderate-to-severe sleep apnea use their breathing machines more consistently. About 48 adults who have never used a PAP machine before will receive either motivational support from a health worker or usual ca…

This study looks at whether endoscopic sinus surgery can improve sleep problems in people with chronic rhinosinusitis and nasal polyps. About 30 adults who have not responded to medication will have their sleep measured before and 3 months after surgery. The goal is to see if rem…

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine properly. Sixty participants will wear active or sham light glasses for…

This study explores whether a non-invasive light treatment called transcranial photobiomodulation (tPBM) can reduce leftover sleepiness in people with obstructive sleep apnea who already use CPAP. About 22 adults with moderate to severe OSA who still feel sleepy despite good CPAP…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called overlap syndrome. Researchers will measure mem…

This early study tests a device that uses tiny electrical pulses to stimulate nerves in the neck, helping keep the airway open during sleep. It is for adults with moderate-to-severe obstructive sleep apnea who cannot use a CPAP machine. The goal is to see if the device is safe an…

This early-phase trial tests whether combining atomoxetine with a new hypnotic drug, DAW2022, can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring b…

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea use their CPAP machine more comfortably. About 30 adults who currently use CPAP but have trouble tolerating it will receive the light treatment. The goal is to …

This study looks at whether eating a whole food plant-based diet can improve sleep apnea and reduce daytime sleepiness. Researchers will measure changes in sleepiness and breathing pauses during sleep in 40 adults. Participants must have mild to moderate sleep apnea and daytime s…

This study looks at whether treating sleep apnea early can improve long-term outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive sleep apnea treatment right away or be placed on a waitlist. The…

This study looks at whether giving extra support and advice helps people with obstructive sleep apnea use their mouthpiece more regularly. About 56 adults aged 40 and older will be split into two groups: one gets routine care, the other gets additional support. Researchers will t…

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. Researchers will measure asthma symptoms and lung function in 138 participants over time. The goal is to see if treating…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will record how babies suck on a pacifier and compare it to sleep test results. The goal is to find a simple, …

This study looks at whether sleep apnea can cause scarring in the heart's upper chambers, even before a heart rhythm problem develops. Researchers will use special MRI scans to measure scarring in 60 adults with different severities of sleep apnea, some with and some without atri…

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea, measuring how fat cells release substances and affect energy and sugar use. The goal is to better unde…

This study looks at whether a daytime sleep test works as well as an overnight one to adjust the Inspire device for people with obstructive sleep apnea. About 110 adults who already have the Inspire implant will take part. The goal is to see if daytime testing can save time and r…

This study looks at a nerve in the neck called the ansa cervicalis, which controls some throat muscles. Researchers want to measure its size and shape in 50 adults having neck surgery for head and neck cancer. They will also stimulate the nerve to see how much it moves the voice …

This study is a registry that follows 1000 people who have or will receive the Inspire implant for obstructive sleep apnea. Researchers will track how well the device works and how consistently patients use it over time during regular clinic visits. No extra tests or treatments a…

This study looks at tongue muscle function in children with suspected obstructive sleep apnea (OSA). Researchers will measure tongue pressure and movement in 78 children referred for sleep testing and compare them to healthy children. The goal is to identify muscle deficits that …

This study explores whether sleep apnea makes multiple sclerosis (MS) worse. Researchers will collect sleep tests, MRI scans, and lab results from 800 adults with MS to see if there is a link. The goal is to understand how sleep apnea might affect MS symptoms and brain changes. N…

This study looks at whether a night of poor sleep can increase abnormal heartbeats in people with obstructive sleep apnea. Researchers will ask 100 adults to wear a heart monitor for 14 days and sometimes skip using their sleep device. The goal is to understand the short-term lin…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth ulcers in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal …

This study will follow 7,000 people with obstructive sleep apnea to see how different sleep patterns relate to long-term health. Researchers will use sleep tests, health records, and additional exams like lung function and blood tests. The goal is to better understand the conditi…

This study aims to better understand obstructive sleep apnea by analyzing blood, saliva, and urine samples from 500 participants. Researchers will track patients over at least one year to see how different severities of sleep apnea affect overall health, immunity, and metabolism.…

This study looks at whether children with a narrow upper jaw (transverse deficiency) are more likely to have obstructive sleep apnea. Researchers will compare 102 children aged 6-16 with and without this jaw issue. The goal is to find a simple physical sign that helps doctors cat…

This study looks at how sleep issues, like sleep apnea, might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, using tests of brain function, sleep quality, and exercise ability. The goal is to find out if …

This study looks at how sex differences may influence the way the body controls blood pressure in people with untreated obstructive sleep apnea (OSA). Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to better unde…

This study aims to create a computer tool that predicts which surgery will work best for each child with obstructive sleep apnea (OSA). About 120 children with persistent OSA after tonsil removal will undergo MRI scans to build detailed models of their airways. The tool simulates…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart and blood vessels. Researchers will compare 240 adults aged 40-79 with one or both conditions to understand why heart problems are more common in overlap syndrome. They will also …

This study looks at whether successfully treating obstructive sleep apnea (OSA) in older adults can improve memory and lower Alzheimer's-related brain changes. About 200 cognitively normal adults aged 55-85 with moderate-to-severe OSA will either receive immediate treatment (CPAP…

This study is checking how well new ResMed CPAP masks work for people with obstructive sleep apnea. About 500 adults who already use CPAP will try the new masks at home. Researchers will track mask leaks, hours of use, and how comfortable the masks feel.

This study looks at older veterans who have both sleep apnea and COPD (a lung condition) to see if having both conditions harms thinking and memory more than having just one. Researchers will also test if treatments like breathing machines or extra oxygen can improve brain functi…

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple measure of how your heart responds to stress. Researchers will monitor 100 adults with high blood pressure who are at risk for OSA using a…

This study explores whether stimulating a nerve in the neck (ansa cervicalis) alone or together with the hypoglossal nerve can improve breathing during sleep in people with obstructive sleep apnea. Researchers will measure airway size, airflow, and breathing effort in 100 adults …

This study looks at two common sedatives, dexmedetomidine and propofol, used during a special sleep endoscopy in children with obstructive sleep apnea. The goal is to see if one drug causes more or less airway collapse, and whether that collapse can predict if sleep apnea will co…

This study explores whether artificial intelligence can predict which sleep apnea treatment works best for each person. Researchers will also test if a smartphone app helps patients stick with mouth and throat exercises. The goal is to make sleep apnea care more personalized and …

This study looks at how a nerve-stimulation implant for obstructive sleep apnea affects airway collapse during sleep. Researchers will use a camera test and a non-invasive method to measure changes in the airway before and after one year of treatment. The study includes 58 adults…

This study looks at whether having obstructive sleep apnea (OSA) might actually protect the body from damage during a type of major blood vessel surgery called aorto-bifemoral bypass. The researchers will compare 100 patients who have OSA with those who do not, measuring markers …

This study looks at how doctors currently screen and treat obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will review medical records of 30 children to see what works and what doesn't. The goal is to create a clear, step-by-step guide to improve care fo…

This study looks at how CPAP therapy, a common treatment for sleep apnea, affects pain in people who also have chronic pain. Researchers will follow 80 adults for 6 months, asking them about their pain levels and checking how well they use their CPAP machine. The goal is to under…

This study looks at 65 adults with obstructive sleep apnea to see how three weeks of breathing therapy (ventilotherapy) changes their thinking skills, blood markers linked to brain health, and overall well-being. Participants take thinking tests, give blood samples, and answer qu…

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and test two methods to change lung volume: a chest ven…

This study reviews medical records of 200 children with obstructive sleep apnea who had tonsil or adenoid surgery. Researchers want to see how often breathing problems happen after surgery, especially in children with obesity, Down syndrome, or neurological disorders. The goal is…

This study looks at whether a treatment called hypoglossal nerve stimulation (HGNS) for obstructive sleep apnea can improve how the body processes sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will take part. Researchers will measu…

This study looks at how common sleep apnea is in Somali-American adults and how it affects their heart health. Researchers will compare 600 Somali, African, Asian, and European participants to find genetic and physical risk factors. The goal is to better understand sleep problems…

This study looks at why people with obstructive sleep apnea often struggle to stick with CPAP therapy, the standard treatment. Researchers will test 64 adults to see if their decision-making style—specifically how much effort they're willing to put in for a reward—predicts poor C…