OBSTRUCTIVE SLEEP APNEA

This study is testing a new approach to treat obstructive sleep apnea (OSA) and its related health issues like high blood pressure and exercise fatigue. Researchers are investigating whether repeated, brief, and safe periods of reduced oxygen, called mild intermittent hypoxia (MI…

This early study is testing whether a nerve stimulation device can effectively treat obstructive sleep apnea in Latin American patients. Researchers will examine how patients' airways respond to the treatment and compare results to previous U.S. studies. The goal is to determine …

This study is testing a new automatic adjustment algorithm for CPAP machines used to treat obstructive sleep apnea. The research will compare the new algorithm against current technology in 80 adults who already use CPAP therapy. Participants will test both algorithms at home and…

This study is testing a new device that uses mild electrical pulses to stimulate nerves in the throat during sleep. The goal is to keep the airway open and reduce breathing pauses in adults with obstructive sleep apnea who cannot use standard CPAP machines. Researchers will impla…

This registry study follows 1,000 patients across Europe who have received the Inspire implant for obstructive sleep apnea. The goal is to track how well the device works over time and how consistently patients use it during routine medical care. Researchers will collect data fro…

This study is testing whether a daytime sleep study works as well as an overnight one for adjusting a sleep apnea treatment device. The device is an implanted nerve stimulator that helps keep the airway open during sleep. Researchers will compare results from 110 patients who hav…

This study is testing a culturally tailored support program to help Native American elders aged 50+ use their sleep apnea machines more consistently. Researchers want to see if better machine use can improve thinking skills and potentially lower the risk of Alzheimer's disease. P…

This study is testing whether a mobile app designed for couples can help people with obstructive sleep apnea use their CPAP machine more consistently. It involves 360 couples where one partner has sleep apnea and is starting CPAP treatment. The couples will use the app to access …

This study aims to find the best surgical treatment for children with obstructive sleep apnea who have small tonsils. Researchers will compare a new, personalized surgical plan based on a detailed sleep scan against the standard surgery of removing the tonsils and adenoids. The g…

This study is testing whether a combination of two drugs, atomoxetine and DAW2020, can reduce the severity of obstructive sleep apnea. Researchers will compare the effects of the drugs to a placebo during overnight sleep studies. The goal is to see if this drug combination can be…

This study is testing a custom mouthpiece for adults with severe obstructive sleep apnea who couldn't use a CPAP machine and also didn't get enough benefit from an implanted nerve stimulator. Researchers want to see if this mouthpiece is safe, practical, and effective at reducing…

This study is testing whether a new injectable drug called maridebart cafraglutide can reduce breathing pauses during sleep for adults with obstructive sleep apnea who are overweight or obese and do not use CPAP therapy. About 250 participants will receive either the drug or a pl…

This study aims to see if artificial intelligence (AI) can predict which treatment works best for each person with obstructive sleep apnea. It will also test if a smartphone app helps people stick to throat exercise therapy. The study involves 300 adults newly diagnosed with slee…

This study is testing whether a two-week course of dronabinol, a medication derived from cannabis, can reduce the severity of obstructive sleep apnea. It will involve about 120 veterans with moderate sleep apnea who will take the oral medication and have sleep studies before and …

This study is testing if using a positive airway pressure (PAP) machine to treat sleep apnea can help people recover better after a stroke. Researchers will compare recovery in 180 stroke patients who use the PAP machine to 180 who receive usual care. The main goal is to see if t…

This study tests whether community health workers can help people with moderate-to-severe sleep apnea use their breathing machine more consistently. Researchers will compare motivational support from trained community workers against standard care. The goal is to improve treatmen…

This study examines whether treating obstructive sleep apnea (using a positive airway pressure device) during a 28-day residential treatment program improves outcomes for Veterans with both PTSD and substance use disorder. Researchers will compare immediate treatment to a delayed…

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use standard CPAP machines. Researchers will follow 60 patients who receive either a custom mouthpiece (MAD) or an implanted nerve stimulator (HGNS). The main goal i…

This study is testing if using a CPAP machine at night can help people who have both severe, uncontrolled asthma and sleep apnea. Researchers will compare asthma control over 12 months in adults who receive standard care versus those who also use a CPAP machine. The goal is to se…

This study is testing if adding lifestyle changes to standard sleep apnea treatment can better control eye pressure in glaucoma. It will involve 40 obese adults who have both glaucoma and sleep apnea. One group will use a CPAP machine nightly, while the other will also follow a l…

This study is testing whether a new drug called maridebart cafraglutide can help control obstructive sleep apnea and reduce weight in adults who are overweight or obese and already use a CPAP machine. It will compare the drug to a placebo over one year to see if it reduces breath…

This study is testing if using a positive airway pressure (PAP) machine at night helps older veterans who have both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea. Researchers want to see if the machine reduces daytime sleepiness, improves sleep quality …

This study is testing a new magnetic device for people with moderate to severe obstructive sleep apnea who can't tolerate CPAP machines. Ten participants will receive a small magnet implanted in their neck, plus a removable external magnet worn during sleep that pulls the airway …

This study aims to find out which type of CPAP machine people with moderate to severe obstructive sleep apnea prefer to use. Fifty participants in Malaysia will try both a standard home CPAP machine and a smaller, portable version for one week each. Researchers will ask them abou…

This study is testing if a personalized surgical approach works better than the standard surgery for treating obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will use a special sleep scope to see exactly where a child's airway is blocked and then plan a …

This study is testing a new device called DidgeriTU, designed to strengthen breathing muscles, to see if it can reduce breathing pauses during sleep for people with mild-to-moderate obstructive sleep apnea. Participants will use either the real device or a look-alike 'sham' devic…

This study is testing a new care program to see if finding and treating a common sleep disorder (obstructive sleep apnea) can help control atrial fibrillation (AFib), a type of irregular heartbeat. About 209 adults with symptomatic AFib will use a simple home sleep test. If sleep…

This study is testing if an implanted nerve stimulator used to treat sleep apnea can also improve blood sugar control and reduce risk factors for heart disease. It will involve 30 adults with moderate-to-severe sleep apnea who cannot use the standard CPAP mask therapy. Researcher…

This study is creating a national registry in Belgium to track the long-term results of an implanted device for obstructive sleep apnea. The device, called Inspire, stimulates a nerve to keep the airway open during sleep. Researchers will follow 225 patients for five years to see…

This study is testing whether a smartphone app called SleepWell24 can help people newly diagnosed with sleep apnea use their CPAP machine more regularly. Researchers want to see if the app helps people reach the goal of using the machine at least 6 hours a night. They will also t…

This study is testing a custom-made mouthpiece, called the OrthoApnea NOA, to see if it can effectively control obstructive sleep apnea. It will follow 150 people for three years to see if the device cuts their breathing pauses in half and improves sleep quality. The research wil…

This study is testing whether a special mouthpiece, already used for mild and moderate cases, is safe and effective for people with severe obstructive sleep apnea. Up to 49 adults with severe sleep apnea will use the device for six months. Researchers will measure if it significa…

This study is testing a new computer tool designed to help doctors predict which surgery will work best for children with obstructive sleep apnea (OSA). Many children continue to have breathing problems during sleep even after surgery, so researchers are using special MRI scans t…

This study compares two sedation medications (dexmedetomidine and propofol) during sleep endoscopy procedures in children with obstructive sleep apnea. Researchers want to see if one medication gives doctors a clearer picture of airway blockages during sleep. The goal is to help …

This study investigates whether effectively treating obstructive sleep apnea (OSA) in older adults can prevent memory decline and reduce early signs of Alzheimer's disease. Researchers will enroll 200 cognitively healthy adults aged 55-85 with moderate to severe OSA. Participants…

This study is testing a soft, self-supporting nasal tube (ssNPA) to see if it can help children with weak throat muscles breathe better during sleep. Researchers will measure if the device reduces sleep apnea events and is comfortable for kids to use. The goal is to improve sleep…

This study is testing if a custom dental mouthpiece, called a Mandibular Advancement Device (MAD), can help reduce the need to wake up to urinate at night in people with obstructive sleep apnea. Researchers will fit 36 adult participants with the device and track their nighttime …

This study is testing whether a non-invasive light therapy can help reduce daytime sleepiness in people who already use a CPAP machine for sleep apnea but still feel tired. Researchers will use a special red light device on participants' heads to see if it improves alertness and …

This study is testing whether a 3-month telehealth program combining lifestyle coaching and supervised exercise can improve quality of life for people with both COPD and sleep apnea. The program will involve 400 overweight or obese veterans who will be randomly assigned to either…

This study is testing whether bright light therapy glasses can help reduce daytime sleepiness in people with obstructive sleep apnea who still feel tired despite using their CPAP machines. Researchers will enroll 60 participants who will wear either active light therapy glasses o…

This study aims to learn more about the nerves that control neck muscles, which might be important for treating sleep apnea. It involves 50 adults already scheduled for neck cancer surgery. During their operation, researchers will carefully map these nerves and test how stimulati…

This study aims to understand how stimulating a specific neck nerve might help keep the airway open in people with obstructive sleep apnea. Researchers will test this nerve stimulation, both alone and combined with an existing tongue nerve treatment, during sleep studies. The goa…

This study aims to find out if children with a narrow upper jaw are more likely to develop obstructive sleep apnea (OSA), a breathing disorder during sleep. Researchers will compare sleep test results from 102 children, some with this jaw shape and some without. The goal is to se…

This study aims to understand how common obstructive sleep apnea is among Somali-Americans and how it might affect their heart health. Researchers will compare 600 adults of Somali, African, Asian, and European descent, some with and some without sleep apnea. The goal is to ident…

This study aims to understand if obstructive sleep apnea causes scarring (fibrosis) in the upper chambers of the heart. Researchers will use a special MRI scan to look for this scarring in 60 people with varying levels of sleep apnea, some with and some without a history of irreg…

This study aims to understand how untreated obstructive sleep apnea affects blood pressure control differently in men versus women. Researchers will measure blood pressure, artery stiffness, and nervous system activity in 60 adults with sleep apnea. The goal is to gather knowledg…

This study aims to understand if obstructive sleep apnea (OSA) is connected to problems in how the body breaks down and uses fat. Researchers will compare fat metabolism in 100 people with and without sleep apnea. They will measure substances released by fat tissue and see how th…

This study aims to understand if a single night of disrupted sleep can immediately increase irregular heartbeats in people with sleep apnea. Researchers will temporarily turn off participants' sleep apnea devices on some nights to disrupt sleep, while monitoring their heart rhyth…

This study aims to understand if a person's lung volume influences how their throat collapses during a key sleep apnea surgery evaluation. Researchers will recruit 200 adults with obstructive sleep apnea who are already scheduled for a standard pre-surgical throat exam under seda…

This study aims to understand why many people with obstructive sleep apnea don't use their CPAP machine consistently, which is the best treatment. Researchers will test if a person's decision-making style, specifically how they weigh effort versus reward, predicts poor adherence.…

This study is looking at past medical records to understand how doctors currently screen for and treat obstructive sleep apnea in children with Down syndrome. By reviewing the care of 30 children, researchers aim to identify the best practices and create a clear, standardized tre…

This study aims to better understand obstructive sleep apnea by closely following 500 patients for at least a year. Researchers will collect blood, saliva, and urine samples to analyze how the condition affects the body's immune system and metabolism over time. The goal is to ide…

This study aims to understand if sleep disturbances, including sleep apnea, make long COVID symptoms like severe fatigue and thinking problems worse. Researchers will observe 200 adults who have had COVID-19, tracking their sleep, memory, and energy levels over time. The goal is …

This study looks back at medical records to understand how often children have breathing problems after tonsil surgery for sleep apnea. Researchers are combining data from two hospitals on 200 children to see if certain conditions, like obesity or Down syndrome, make these compli…

This study aims to understand how a standard sleep apnea treatment (ventilotherapy) affects patients' thinking skills, brain health markers, and overall well-being. Researchers will observe 65 adults with sleep apnea, measuring their memory, attention, mood, and blood markers bef…

This study aims to understand why people who have both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea face a much higher risk of heart problems and death. Researchers will compare 240 adults with either condition alone or both together, measuring heart h…

This study aims to understand if having both obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) causes more thinking and memory problems than having just one of these conditions. Researchers will enroll 108 older veterans to compare their thinking skil…

This study aims to better understand the different patterns, or 'phenotypes,' of obstructive sleep apnea by observing 7,000 patients. Researchers will collect detailed sleep test data, symptoms, and long-term health records to see how these factors connect. The goal is to learn i…

This study aims to understand how a nerve stimulation treatment for sleep apnea physically changes the airway. Researchers will use a special sleep scope and a new prediction tool to measure where and how much the airway collapses before and one year after patients receive the im…

This study aims to understand if using a CPAP machine to treat obstructive sleep apnea can also help reduce chronic pain. Researchers will follow 80 people newly diagnosed with sleep apnea as they start CPAP therapy, tracking their pain levels and CPAP use over 6 months. The goal…

This study aims to understand why some people, especially children, develop PFAPA syndrome—a condition causing recurring fevers, sore throats, and mouth sores—and other tonsil disorders. Researchers will collect blood, saliva, and other samples from 1500 participants to look for …