OBSTRUCTIVE SLEEP APNEA

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help women with Polycystic Ovary Syndrome (PCOS). The researchers want to see if better sleep can lower insulin resistance and improve hormone levels. The study involves 20 women aged 18-40 with…

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children with Down syndrome who have obstructive sleep apnea. The goal is to see if the treatment improves sleep breathing problems and thinking skills. The study involve…

This study tracks 110 adults with moderate to severe obstructive sleep apnea who have the Genio® device implanted. The device is designed to keep the airway open during sleep. Researchers are checking for serious side effects and measuring improvements in breathing and quality of…

This study tests a once-weekly injection called retatrutide for weight loss in people with obesity or overweight who do not have diabetes. About 2,335 participants will receive the drug or a placebo for up to 89 weeks. The study also looks at how the drug affects knee osteoarthri…

This study tests whether the sleep medication trazodone can slow down memory decline in people who have both mild cognitive impairment (MCI) and obstructive sleep apnea (OSA). About 134 participants will take either trazodone or a placebo for one year. Researchers will measure ch…

This study tests a device that stimulates a nerve in the tongue to help with sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if better sleep from the device also improves thinking, attention, memory, and language skills over 12 months.…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot use standard CPAP therapy. Researchers will measure blood pressure changes over 36 weeks. The goal is …

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are overweight or have obesity. The goal is to see if it helps with weight loss and, for a subset with sleep apnea, improves breathing during sleep. Participants receive eithe…

This study looks at how well a special nasal tube works over a long period for children with weak muscle tone (hypotonia) who have obstructive sleep apnea. About 40 children who already used the device in earlier studies will continue using it. Researchers will check if the devic…

This study tests a small implant that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate-to-severe obstructive sleep apnea who cannot use a CPAP machine. The main goal is to see if the device safely reduces breathing pauses and imp…

This study checks if a device called RPMO2 can accurately measure drops in oxygen levels during sleep in people with obstructive sleep apnea. About 30 adults with sleep apnea will use the device during one night in a sleep lab, while also having the standard sleep test. The goal …

This study explores whether short video clips recorded by parents on their smartphones can help identify children with Down syndrome who are at high risk for obstructive sleep apnea (OSA). About 141 children will participate. Parents will record their child sleeping and then gues…

This study checks how well a new home sleep test system, SleepView+, can detect moderate to severe sleep apnea in people aged 12 and older. Participants first use the device in a sleep lab alongside standard tests, then try it at home on their own. The goal is to see if the devic…

This study tests whether showing sleep apnea patients how their CPAP machine use compares to other patients helps them use it more regularly. About 186 adults who have been on CPAP for at least three months will be randomly assigned to get either their own usage data or their dat…

This study tests whether taking a commercially available ketone drink (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use CPAP therapy. Participants will try two different doses and have their blood ketone levels and sleep…

This study aims to find genetic variants linked to obstructive sleep apnea and its related health problems. Researchers will collect sleep questionnaires and genetic samples from 5,000 adults who have or are suspected of having sleep apnea. The goal is to better understand the co…

This study was designed to look at the glossopharyngeal nerve, which helps keep the upper airway open. Researchers planned to measure the nerve's shape and test if electrical stimulation could improve breathing during surgery. The study was withdrawn before enrolling any particip…

This study planned to see if treating obstructive sleep apnea with a CPAP machine could improve insulin resistance and heart function in people with heart failure. It was designed for adults aged 18 to 75 with moderate to severe sleep apnea and reduced heart pumping ability. Howe…

This study looks at whether a video call (tele-visit) works as well as a home visit from a healthcare provider to help people with obstructive sleep apnea stick with their CPAP therapy. About 320 adults who have been using CPAP for at least a year will take part. The goal is to s…

This study looks at 10,000 people with both sleep apnea and high blood pressure to see how well their treatments work together to prevent major heart problems or death. Researchers will track whether using a breathing machine at night (PAP) and taking blood pressure medicine lowe…

This study looks at how special exercises for the tongue and throat muscles might help people with obstructive sleep apnea. Thirty adults with sleep apnea will use myofunctional therapy devices for 3 months. Researchers will measure muscle pressure in the throat to understand why…

This study looks at how common obstructive sleep apnea is in adults who survived Hodgkin lymphoma after chest radiation. Researchers will compare 220 survivors to similar people without cancer to see if radiation increases sleep apnea risk. They also want to find links between sl…

This study looked at whether sleep-disordered breathing (like sleep apnea) is linked to faster spine curve worsening in children with idiopathic scoliosis. Researchers followed 405 children aged 6 to 15 with mild to moderate curves. They measured spine angles and sleep quality to…

This study analyzes data from 10,000 people with obstructive sleep apnea to see if CPAP therapy affects blood pressure differently in those who are excessively sleepy versus those who are not. Researchers will compare office and 24-hour blood pressure readings between the two gro…

This study looks at how stimulating two tongue muscles (palatoglossus and genioglossus) affects airway size during a sleep endoscopy procedure. It involves 60 adults with obstructive sleep apnea who cannot use CPAP. The goal is to gather basic measurements to improve nerve stimul…

This study aims to develop a computer model that can predict how airway surgery will affect nighttime breathing in children with Down Syndrome who have obstructive sleep apnea. Researchers will measure airway resistance during a sleep MRI to improve the model. The study involves …

This study checks how well sleep questionnaires work for children with Down syndrome, who often have sleep apnea. About 81 children aged 2-17 will fill out surveys, and their results will be compared to a standard sleep test. The goal is to find a simple way to spot sleep problem…

This study looks at 196 adults with mild-to-moderate sleep apnea to see whether inflammation or the severity of apnea (measured by breathing pauses during sleep) better predicts heart and metabolic problems like high blood pressure, diabetes, and unhealthy cholesterol. Participan…

This study aims to find out if removing upper premolars to fix prominent front teeth in children increases the risk of obstructive sleep apnea. Researchers will compare sleep study results before and after orthodontic treatment in 60 children aged 10-15. The goal is to see if thi…

This study was designed to find out how obstructive sleep apnea (OSA) speeds up the natural drop in testosterone as men age. Researchers planned to test men aged 30-70 with moderate to severe OSA using a special hormone-blocking drug to measure how the brain and testes communicat…

This study looks at whether a breathing device called adaptive servo-ventilation (ASV), used for 6 months, can improve how the heart uses energy and how well the heart's nerves work in people with heart failure and sleep apnea. About 60 adults will have heart scans and heart rate…

This study looks at whether keeping the breathing tube in a bit longer after gastric cancer surgery can lower the risk of complications in patients who also have severe obstructive sleep apnea. About 240 adults aged 18-85 with resectable gastric cancer and severe sleep apnea will…

This study tested whether a supplement called N-acetylcysteine (NAC) affects oxidative stress and inflammation differently in men and women with obstructive sleep apnea. Fourteen participants who already use standard CPAP therapy took NAC or a placebo for 4 weeks. The goal was to…

This early study at Mayo Clinic tests whether using an automated leg massage device (Neuroglide) each night for one month can improve the brain's waste-clearing system in people aged 50+ with obstructive sleep apnea. Researchers will measure changes in blood markers linked to bra…