Obstructive sleep apnea

This phase 3 trial tests whether UBT251, an investigational drug given as a weekly injection, can reduce breathing pauses during sleep in adults with moderate-to-severe obstructive sleep apnea who also have obesity. Participants continue their usual positive airway pressure (PAP)…

This trial tests whether four weeks of supervised aerobic exercise can improve sleep and nervous system function in adults with mild to moderate obstructive sleep apnea. Researchers will compare an exercise group with a sleep-education-only group, measuring changes in sleep apnea…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This UK trial tests a device that uses mild electrical pulses to keep the airway open during sleep in people with obstructive sleep apnoea. It is for adults who cannot use standard CPAP therapy. The study will compare the device to usual CPAP care over three months to see if it i…

Researchers compare automated software with manual scoring by expert sleep specialists for sleep study records from adults with obstructive sleep apnea. The study measures how closely the two methods agree on the apnea-hypopnea index, a key measure of breathing pauses during slee…

Obstructive sleep apnea is common but often undiagnosed, and standard sleep tests can be slow to access. Researchers are studying Apneal Dx, a CE-marked smartphone app that uses the phone's sensors worn on the chest to record breathing during sleep. The study follows adults in fi…

This study will test several new wearable devices and a mobile app to see how well they diagnose obstructive sleep apnea (OSA) compared to the standard overnight sleep test. About 90 adults will wear devices like a finger sensor, wristband, ring, patches, and an eye mask while al…

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

Researchers are testing whether a monthly injection of berobenatide can reduce the severity of obstructive sleep apnea and lower body weight in adults who have overweight or obesity and use a PAP breathing machine. The trial enrolls about 258 adults with moderate to severe sleep …

This study tests a new, compact CPAP device worn on the head, designed to treat obstructive sleep apnea. Ten adults who already use CPAP will try the device during a supervised daytime nap to see how comfortable, stable, and easy it is to use. The goal is to gather feedback that …

This study tests two different CPAP devices for people newly diagnosed with obstructive sleep apnea. One device uses a feature called KPAP, the other uses EPR. Researchers will compare how well each device controls breathing pauses during sleep and how patients feel about their s…

This study tests whether a decision-making tool can help veterans with sleep apnea choose and stick with a treatment that works for them. About 128 veterans will be randomly assigned to receive either a brief education program or the same program plus a personalized tool. The goa…

This study tests whether a culturally tailored text-message program can help Spanish-speaking Hispanic adults with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. Fifty adults will receive automated texts that offer support, troubleshoo…

This study tests whether taking steroids (dexamethasone) for a few days after sleep surgery helps reduce pain, allows patients to eat solid food sooner, and lowers the need for strong painkillers. About 120 adults with obstructive sleep apnea will receive either the steroid or a …

This study compares a new device called KPAP to standard APAP for treating obstructive sleep apnea. The goal is to see if KPAP, which delivers lower pressure during breathing out, is more comfortable and used more each night. About 30 adults with sleep apnea will try both devices…

This study tests new parts for PAP machines (the devices that help people with sleep apnea breathe at night). Researchers want to see if the new masks, tubes, or machines are as comfortable and easy to use as current ones. About 30 adults who already use a PAP machine will try th…

This study looks at whether orofacial myofunctional therapy (OMT) – exercises for the mouth and tongue – can improve sleep apnea symptoms in adults with mild-to-moderate cases. It will compare OMT alone, CPAP alone, both together, and standard care in 168 participants over 12 wee…

This study compares how comfortable two different sleep apnea machines feel to people who have never used one before. Twenty-four adults with newly diagnosed obstructive sleep apnea will try each machine for 4 nights at home. The goal is to see which device people find more comfo…

This study tests a wearable smart eye-mask that combines gentle heat and massage with voice-guided sleep therapy to help people who have both insomnia and sleep apnea. The 4-year project will first explore how the condition works, then develop the device, and finally test it in 1…

Researchers are studying whether a blood protein called adropin can signal blood vessel damage and disease severity in obese adults with obstructive sleep apnea. The trial compares adropin levels in obese patients with and without the sleep disorder, and checks how those levels r…

Researchers at a French sleep center are studying adults with obesity who are referred for a sleep study because of suspected obstructive sleep apnea. The team measures how much carbon dioxide builds up in the blood overnight using a skin sensor, then compares that cumulative exp…

This study will give the nasal flu vaccine to 25 people who are already scheduled to have their tonsils or adenoids removed for sleep apnea. Researchers will then study the removed tissue to see how the vaccine affects immune cells near the nose. The goal is to better understand …

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This study investigates whether obstructive sleep apnea is linked to metabolic associated fatty liver disease (MAFLD) in adults. Researchers will measure sleep apnea severity using overnight sleep tests and liver fat using a special ultrasound-like scan. The goal is to see if wor…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study will test a new wearable device that monitors your body's internal clock (circadian rhythm) by tracking signals like heart rate and movement. Researchers will compare the device's readings to standard saliva tests in 30 adults who are either healthy, have sleep apnea, …

This study looks at whether children aged 6 to 12 with a specific teeth alignment issue (posterior crossbite) are more likely to have obstructive sleep apnea. Researchers will use a questionnaire to measure sleep apnea risk in 420 children. The goal is to understand if there is a…

This study looks at why many people with obstructive sleep apnea still feel very sleepy during the day even after successful treatment with CPAP or other devices. Researchers will test 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this lef…

This study looks at whether a simple arm exercise test, called the 6-Minute Pegboard and Ring Test, can reliably measure upper body function in adults with obstructive sleep apnea. Researchers will compare test results with sleep study data and questionnaires. The goal is to impr…

This study will follow 1200 people who have had a heart attack or unstable angina and also have sleep apnea. Researchers will collect blood, urine, and stool samples to understand how sleep apnea affects metabolism and heart risk. The goal is to build an AI-based tool to better p…

This study looks at how a device that stimulates a nerve in the tongue changes the way the upper airway collapses in people with obstructive sleep apnea. Researchers will measure airway collapsibility during a sleep endoscopy in 21 adults already using the therapy. The goal is to…