OBSTRUCTIVE SLEEP APNEA

This study is testing a device called the Genio® System to help people with moderate to severe obstructive sleep apnea who cannot use or tolerate standard treatments like CPAP machines. The device is implanted and stimulates the tongue to keep the airway open during sleep. Resear…

This study looks at whether using a CPAP machine for 12 months after a heart procedure (catheter ablation) can lower the chance of atrial fibrillation coming back in people who also have obstructive sleep apnea. About 658 adults aged 18-75 with both conditions will be randomly as…

This study tests a device that uses mild electrical stimulation to keep the airway open during sleep in people with obstructive sleep apnea who cannot tolerate CPAP. About 186 adults with mild to moderate sleep apnea will use the device at home for 3 months. The goal is to see if…

This study tests whether combining a tongue-stimulating implant (HGNS) with an experimental drug combo (AtoOxy) can reduce breathing pauses during sleep more than either treatment alone. About 24 adults with obstructive sleep apnea who already have or will get the implant will tr…

This study will test how well new medical devices can diagnose obstructive sleep apnea (OSA) compared to the current gold standard test (PSG). About 90 adults with suspected or known OSA will participate. The goal is to see if these devices are accurate and can correctly identify…

This study compares two CPAP machines for people newly diagnosed with obstructive sleep apnea. 24 adults will try both devices during overnight sleep studies to see which one better reduces breathing pauses and improves sleep quality. The goal is to find which technology offers m…

This study tests whether taking dronabinol (a synthetic cannabis-like drug) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. T…

This study compares how comfortable two different sleep apnea machines feel to people who have never used one before. Participants will try each machine for 4 nights at home and rate their comfort. The goal is to see which machine people prefer, which could help improve treatment…

This study looks at whether orofacial myofunctional therapy (mouth and tongue exercises) and CPAP, alone or together, can reduce sleep apnea severity in adults with mild-to-moderate obstructive sleep apnea. About 168 participants will be randomly assigned to one of four groups: s…

This study will test new parts for PAP machines, like masks and tubing, to see if they are more comfortable and easier to use than current ones. About 30 adults with sleep apnea who already use a PAP machine will try the new parts for up to 7 nights each. The goal is to improve t…

This study tests a wearable voice-guided therapy for people with both insomnia and sleep apnea. About 361 adults will use a smart eye-mask that talks them through sleep exercises. The goal is to improve sleep quality and help people stick with their CPAP machine.

This study compares a new positive airway pressure device (KPAP) to a standard automatic one (APAP) for treating obstructive sleep apnea. The goal is to see if KPAP is more comfortable and used more each night. Thirty adults with sleep apnea will try both devices at home for seve…

This study tests whether taking steroids after sleep surgery helps adults with obstructive sleep apnea feel less pain, eat normally sooner, and use fewer painkillers. About 120 adults will receive either steroids or a placebo for a short time after their operation. The goal is to…

This study is testing if a drink containing ketones (Ketone-IQ), taken before bed, can improve sleep quality and reduce the severity of obstructive sleep apnea. Researchers want to see if this is an easier alternative to following a strict ketogenic diet. The study will involve 3…

This study looks at how a device that stimulates a nerve in the tongue (hypoglossal nerve stimulation) changes how easily the upper airway collapses in people with obstructive sleep apnea. Researchers will measure airway collapsibility during a sleep endoscopy before and after th…

This study looks at whether a 6-minute arm test (moving rings on a board) is a valid and reliable way to measure upper body function in adults with obstructive sleep apnea. About 80 participants will take the test twice to check consistency, and their results will be compared wit…

This study looks at why over a third of people treated for obstructive sleep apnea still feel very sleepy during the day, raising their risk of accidents. Researchers will measure oxygen drops during sleep and compare them to results from a standard alertness test. They will also…

This study looks at 270 adults with moderate to severe sleep apnea to find better ways to measure heart and blood vessel changes. Researchers will use sleep tests and heart ultrasounds to see how different treatments like CPAP, mouth devices, or nerve stimulation affect heart hea…