MYELODYSPLASTIC SYNDROME

This study is testing whether adding a new oral drug called seclidemstat to a standard chemotherapy (azacitidine) is safe and effective for patients with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The trial will first find the best dose and then se…

This early-stage trial is testing whether adding specially treated immune cells, called 'veto cells,' can help patients with blood cancers or bone marrow failure after a stem cell transplant. The goal is to help the donor's cells grow in the patient's body without causing a dange…

This early-phase study is testing the safety and best dose of a targeted radiation treatment, given with two chemotherapy drugs, to prepare patients for a donor stem cell transplant. The goal is to better wipe out cancer cells in the bone marrow before receiving healthy donor cel…

This study is testing whether an experimental drug called HT-6184 can help people with myelodysplastic syndrome (MDS) who have developed anemia that hasn't responded to standard treatments. The trial involves 37 adults with low to intermediate risk MDS who will take the drug for …

This study is testing whether combining two chemotherapy drugs is safe and effective for treating adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or hasn't responded to other treatments. The goal is to control the disease, p…

This study is testing new radiation techniques to better protect patients' lungs during stem cell transplants for leukemia and related blood cancers. Researchers want to see if using more precise radiation methods can reduce lung damage while still effectively treating the cancer…

This study is testing a combination of three oral chemotherapy drugs for people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't had prior treatment. The first phase aims to find the safest dose, and the second phase measures how…

This study aims to find the most effective drug combination for treating higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), which are serious blood and bone marrow disorders. Researchers are comparing a standard chemotherapy drug (azacitidine)…

This large study aims to determine the best type of donor for stem cell transplants in children and young adults with high-risk leukemia or myelodysplastic syndrome (MDS). It directly compares transplants from a partially matched family member (haploidentical) to those from a ful…

This study is testing a new combination of three drugs—navitoclax, venetoclax, and decitabine—for patients with a high-risk type of blood and bone marrow cancer called myelodysplastic syndrome (MDS) that has come back or hasn't responded to standard treatments. The main goals are…

This program provides access to Orca-T cell therapy for patients with blood cancers when the standard commercial product doesn't meet quality specifications. It's designed for patients who were already scheduled to receive Orca-T but whose manufactured product didn't pass all rel…

This study is testing whether a detailed health assessment can help doctors personalize the intensity of a stem cell transplant for older adults (age 60+) with certain blood cancers. The assessment looks at factors like thinking skills, physical ability, and mood to decide if a p…

This study is testing a two-drug chemotherapy regimen followed by a donor stem cell transplant for adults with certain blood cancers that are in remission or at high risk. The goal is to see if this approach can better control the disease and prevent it from coming back after the…

This study is testing the safety and effectiveness of combining two drugs, vorinostat and azacitidine, for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination can better control the disease by…

This early-stage study is testing the safety and best dose of an experimental drug called AZD6738 for adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has progressed after initial treatment. The drug works by blocking a specific protein in…

This early-stage study is testing a new drug called DR-18 for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) whose cancer has come back or persisted after a stem cell transplant. The main goals are to find a safe dose and see what side effects it cau…

This study is testing if adding a drug called pomalidomide to standard chemotherapy works better for adults newly diagnosed with a specific, harder-to-treat type of acute myeloid leukemia (AML). About 50 participants will be randomly assigned to receive either the standard chemo …

This study is testing a new oral drug called CA-4948 (emavusertib) for adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or hasn't responded to prior treatments. The main goals are to find the safest and most effective dose an…

This trial is comparing a new, engineered cell transplant called Orca-T against the standard transplant for people with advanced blood cancers like leukemia. The goal is to see if Orca-T can better control the cancer while reducing a serious complication called graft-versus-host …

This study is testing if a two-drug oral combination works better than a single oral drug to control symptoms and reduce cancer cells in patients with certain aggressive blood cancers, including chronic myelomonocytic leukemia (CMML). It is a Phase 2 trial with 132 participants, …

This study is testing a combination of three drugs—azacitidine, venetoclax, and pevonedistat—for adults newly diagnosed with certain high-risk blood cancers. These include acute myeloid leukemia (AML) that developed from other blood disorders or prior cancer treatment, as well as…

This study is testing whether two drugs, palifermin and leuprolide acetate, can help a patient's immune system recover more quickly after receiving a stem cell transplant from a donor. The transplant is for patients with blood cancers like leukemia or lymphoma. Researchers want t…

This study aims to find out which of two chemotherapy combinations works better to prepare patients for a donor stem cell transplant. The transplant is a treatment for certain aggressive blood cancers. Researchers are comparing the drugs treosulfan and clofarabine to see which on…

This study is testing whether combining two immunotherapy drugs (nivolumab and ipilimumab) with a chemotherapy drug (azacitidine) is safe and effective for treating myelodysplastic syndromes (MDS), a type of blood and bone marrow cancer. It is for 99 patients, including those new…

This study is testing whether adding a drug called venetoclax to the standard chemotherapy given before a donor stem cell transplant works better for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to better prepare the body to accept the…

This study is testing a new, more targeted form of radiation as a preparatory step before a stem cell transplant. It is for patients with certain types of leukemia or myelodysplastic syndrome who need a transplant but do not have a fully matched donor. The goal is to see if this …

This study is testing a modified stem cell transplant procedure for patients with high-risk blood cancers. The goal is to see if using specific chemotherapy drugs in a timed sequence before and after the transplant can better control the cancer while reducing harmful immune react…

This early-stage study is testing a new therapy for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or persists after standard treatment, including a stem cell transplant. Researchers take immune cells (T cells) from the patient's orig…

This early-stage study is testing a new drug called INCB057643, both alone and in combination with an existing drug (ruxolitinib), in adults with advanced blood cancers like myelofibrosis. The main goal is to check if the treatment is safe and tolerable. Researchers will also loo…

This study is testing a new combination of two drugs, guadecitabine and atezolizumab, for adults with advanced myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML). It is for patients whose cancer has returned or stopped responding to standard treatments. The …

This large, late-stage trial is comparing two treatment approaches for patients with a bone marrow disorder (MDS) and severe anemia. It tests whether a drug called lenalidomide works better alone or when combined with a hormone (epoetin alfa) that helps the body make red blood ce…

This study is testing a new blood test called AlloHeme to see if it can predict when leukemia or a related blood cancer might return after a patient receives a bone marrow transplant. Researchers will track over 300 patients for two years, collecting regular blood and bone marrow…

This study is testing a new vaccine approach to prevent a common and dangerous viral infection called CMV in patients receiving a stem cell transplant for blood cancer. Researchers are vaccinating the healthy stem cell donors before the transplant, hoping the donor's boosted immu…

This study is testing a vaccine designed to prevent cytomegalovirus (CMV) infection in adults with blood cancers who are receiving a half-matched stem cell transplant. CMV is a common virus that can become life-threatening when the immune system is weakened after transplant. The …

This study aims to understand why cancer survivors who receive stem cell transplants have a higher risk of heart disease. Researchers will measure how well the heart, lungs, and muscles work together in 350 adult patients before their transplant and for two years after. The goal …