MYELODYSPLASTIC SYNDROME

This large, completed Phase 3 trial tested if adding a new drug called pevonedistat to the standard drug azacitidine was better than azacitidine alone. It involved 454 adults with higher-risk forms of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or low…

This study tested a two-step, lower-intensity stem cell transplant for patients with high-risk blood cancers like leukemia and lymphoma. The goal was to control the cancer by first using low-dose chemotherapy and radiation to prepare the body, then infusing donor stem cells to at…

This early-stage study tested a combination of two drugs, bortezomib and lenalidomide, in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) had returned after a stem cell transplant. The main goal was to find the highest dose of this drug pair that co…

This small, early-stage study aimed to find a safe dose for combining two existing drugs, ibrutinib and lenalidomide, to treat myelodysplastic syndrome (MDS). It involved patients whose MDS had not responded to or who could not tolerate standard treatments. The main goal was to c…

This study tested a two-part treatment for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a donor stem cell transplant. It combined a drug called guadecitabine, which may slow cancer growth, with infusions of the donor's white blood ce…

This study tested whether adding 'off-the-shelf' natural killer (NK) immune cells from a donor could make stem cell transplants more effective for adults with high-risk forms of leukemia. The goal was to see if this combination was safe and could help prevent the cancer from comi…

This early-stage study tested two immunotherapy drugs, nivolumab and ipilimumab, in patients with high-risk or returning acute myeloid leukemia or myelodysplastic syndrome who had already received a donor stem cell transplant. The main goals were to find safe doses and check for …

This early-stage study tested a combination of a cancer vaccine, chemotherapy, and immunotherapy in 8 patients with certain high-risk blood cancers. The main goal was to check the safety of this four-drug approach and see if it could help the body's immune system better target an…

This study aimed to identify what helps older adults recover well after a bone marrow transplant for blood cancers like leukemia and lymphoma. Researchers measured physical ability, mental health, stress hormones, and other factors in 126 patients aged 60 and older before and aft…