Can adding another drug improve MDS treatment?

NCT ID NCT01522976

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Sep 10, 2026 · Updated 5 times

Summary

This study compares the standard drug azacitidine alone versus azacitidine combined with either lenalidomide or vorinostat in 282 patients with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The goal is to see if any combination improves response rates or overall survival. Participants receive these drugs by injection or by mouth, and researchers track outcomes over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: azacitidine, lenalidomide, vorinostat
What this could lead to: If successful, this could identify a more effective drug combination to control higher-risk MDS or CMML and extend survival.
What could go wrong: This is a phase 2/3 trial, so results are not yet definitive. The combinations may not prove better than azacitidine alone and could cause additional side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

282 people

The number who actually took part.

Started

Mar 2012

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must have morphologically confirmed diagnosis of myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) based on one of the following: * French-American-British (FAB) classifications: * Refractory anemia with excess blasts (RAEB - defined as having 5-20% myeloblasts in the bone marrow) * Chronic myelomonocytic leukemia (CMML) with 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood * World Health Organization (WHO) classifications: * Refractory anemia with excess blasts-1 (RAEB-1 - defined as having 5-9% myeloblasts in the bone marrow) * Refractory anemia with excess blasts-2 (RAEB-2 - defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood) * Chronic myelomonocytic leukemia-1 (CMML-1 - defined as having \< 10% myeloblasts in the bone marrow and/or \< 5% blasts in the blood) * Chronic myelomonocytic leukemia-2 (CMML-2 - defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood) OR * International prognostic score (IPSS) of intermediate 2 (1.5-2.0 points) or high (\>= 2.5 points); a score of intermediate 1 (0.5-1.0 points) is only allowable in the setting of \>= 5% myeloblasts * NOTE: Patients with acute myeloid leukemia (AML) are not eligible * Procedures to obtain specimens for establishing baseline disease must be done within 30 days prior to registration * Patients must not have received lenalidomide, azacitidine, vorinostat, or decitabine as treatment previously; any hematopoietic growth factors must be stopped for at least 14 days prior to registration; patients may have received low-dose cytarabine for MDS treatment previously, but they must have discontinued its use for at least 28 days prior to registration; patients may have received prior hydroxyurea per CMML treatment previously, but they must have discontinued its use for at least 7 days prior to registration; these patients will not be eligible if white blood cell (WBC) \> 30,000/mm\^3 * Patients must not have received radiation therapy, chemotherapy, or cytotoxic therapy to treat conditions other than MDS within 12 months prior to registration * Patients must not have undergone prior allogeneic stem cell or bone marrow transplantation at any time; patients that have undergone an autologous stem cell transplant are eligible * Patients must not have used or be using histone deacetylase (HDAC) inhibitor agents for anticancer treatment * Patients may not have received agents such as valproic acid for epilepsy within 30 days prior to registration * Patients must have Zubrod performance status of 0-2 * Patients must not have any pre-existing neurotoxicity/neuropathy of \>= grade 2 according to the National Cancer Institute (NCI) Common Toxicity Criteria version 4.0, or prior \>= grade 3 allergic reaction/hypersensitivity or rash to thalidomide, that has not resolved to \< grade 2 * Patients must not have any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving informed consent * Patients must not have history of thromboembolic event or other condition requiring current use of anticoagulation with Coumadin (warfarin) or low molecular-weight heparin * Patients must not have known or suspected hypersensitivity to mannitol * Patients must receive a 12-lead electrocardiogram (EKG), chest x-ray or computed tomography (CT) scan, serum creatinine, complete metabolic panel including serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT), electrolytes, and bilirubin testing within 28 days prior to registration in order to establish baseline measurements; questions regarding patient safety in regards to results of these tests should be directed to the study chair * Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days prior to registration; FCBP must agree to have a second pregnancy test within 24 hours prior to starting cycle 1 if randomized to receive lenalidomide * Further, patients commit to the following if they are randomized to receive lenalidomide: FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure * NOTE: Patients not randomized to receive lenalidomide will not be required to undergo serial pregnancy testing or lenalidomide counseling after registration * No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for three years * Cytogenetics requirements: * Southwestern Oncology Group (SWOG) (and other sites not affiliated with Alliance or Eastern Cooperative Oncology Group \[ECOG\]-American College of Radiology Imaging Network \[ACRIN\]): Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 30 days prior to registration to S1117; specimens must be submitted to the site's preferred Clinical Laboratory Improvement Amendments (CLIA)-approved cytogenetics laboratory; reports of the results must be submitted as described; note that cytogenetics are required at other timepoints; NOTE: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) sites may submit specimens to College of American Pathologists (CAP) or Ontario Laboratory Accreditation (OLA)-approved laboratories providing the lab is licensed to perform fluorescent in situ hybridization (FISH) analysis * Alliance: Alliance patients must enroll on Cancer and Leukemia Group B (CALGB) 8461, the cytogenetics protocol; CALGB 8461 provides sample procurement and submission instructions to Alliance-approved institutional cytogeneticists; note that cytogenetics are required at other timepoints * ECOG-ACRIN: Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 30 days prior to registration to S1117; specimens must be submitted to the site's preferred CLIA-approved cytogenetics laboratory; karyotypes and reports must be submitted for review to the Mayo Clinic Cytogenetics Laboratory in Rochester; note that cytogenetics testing is required at other timepoints * Banking requirements: * SWOG, Alliance and ECOG-ACRIN (and other sites not affiliated with NCIC CTG): Patients must be offered participation in specimen banking; with patient consent, specimens must be submitted as outlined * Alliance: (Temporarily Closed 2/28/14): As of February 28, 2014, CALGB 9665 has been temporarily closed, so Alliance patients under consideration for S1117 are NOT to be registered to CALGB 9665 and no specimens for patients enrolled after February 28, 2014 are to be submitted via this ancillary study; these patients should submit specimens per SWOG instructions; patients already enrolled on CALGB 9665 should continue to submit specimens per instructions in CALGB 9665 * NCIC CTG: NCIC CTG patients must be offered participation in specimen submission and banking; with patient consent, specimens must be submitted as outlined * All patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

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Conditions

The condition(s) this trial relates to.

chronic myelomonocytic leukemia GATA2 Deficiency myelodysplastic syndrome myelodysplastic syndrome with excess blasts myelodysplastic syndrome with excess blasts-1 Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic myelomonocytic leukemia Chronic myelomonocytic leukemia-1 Chronic myelomonocytic leukemia-2 Myelodysplastic syndrome Myelodysplastic syndrome with excess blasts Myelodysplastic syndrome with excess blasts-1 Myelodysplastic syndrome/acute myeloid leukemia

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
AdventHealth Littleton

Littleton, Colorado, 80122, United States
AdventHealth Orlando

Orlando, Florida, 32803, United States
AdventHealth Parker

Parker, Colorado, 80138, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
Annie Penn Memorial Hospital

Reidsville, North Carolina, 27320, United States
Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States
Atlantic Health Sciences Corporation-Saint John Regional Hospital

Saint John, New Brunswick, E2L 4L2, Canada
Augusta University Medical Center

Augusta, Georgia, 30912, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States
Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
CSSS Champlain-Charles Le Moyne

Greenfield Park, Quebec, J4V 2H1, Canada
Cancer Care Associates-Norman

Norman, Oklahoma, 73071, United States
Cancer Research Consortium of West Michigan NCORP

Grand Rapids, Michigan, 49503, United States
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Christiana Care - Union Hospital

Elkton, Maryland, 21921, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Cleveland Clinic Cancer Center Beachwood

Beachwood, Ohio, 44122, United States
Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Clinical Research Unit at Vancouver Coastal Health Authority

Vancouver, British Columbia, V5Z 3P1, Canada
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
CommonSpirit Saint Anthony Hospital Cancer Center

Lakewood, Colorado, 80228, United States
Cone Health Cancer Center

Greensboro, North Carolina, 27403, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606, United States
Covenant Health Cancer Centers

Knoxville, Tennessee, 37916, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute at Boston Medical Center - Brighton

Brighton, Massachusetts, 02135, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States
ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States
Eastern Maine Medical Center

Bangor, Maine, 04401, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, 54301-3526, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
HSHS Sacred Heart Hospital

Eau Claire, Wisconsin, 54701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Hematology and Oncology Associates

Chicago, Illinois, 60611, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Hutchinson Area Health Care

Hutchinson, Minnesota, 55350, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Community Cancer Center

Normal, Illinois, 61761, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Havana

Havana, Illinois, 62644, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Monmouth

Monmouth, Illinois, 61462, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States
Iredell Memorial Hospital

Statesville, North Carolina, 28677, United States
John L McClellan Memorial Veterans Hospital

Little Rock, Arkansas, 72205, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Jupiter Medical Center

Jupiter, Florida, 33458, United States
Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, L8V 5C2, Canada
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-San Rafael

San Rafael, California, 94903, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kansas City NCI Community Oncology Research Program

Prairie Village, Kansas, 66208, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McGill University Department of Oncology

Montreal, Quebec, H2W 1S6, Canada
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
MercyOne Waterloo Cancer Center

Waterloo, Iowa, 50702, United States
Mercyhealth Hospital and Cancer Center - Janesville

Janesville, Wisconsin, 53548, United States
Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Mid Dakota Clinic

Bismarck, North Dakota, 58501, United States
Minneapolis VA Medical Center

Minneapolis, Minnesota, 55417, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States
Mountain Blue Cancer Care Center

Golden, Colorado, 80401, United States
Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Shore University Hospital

Manhasset, New York, 11030, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Hospital and Medical Group

Escanaba, Michigan, 49829, United States
Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Premier Oncology Hematology Associates

Merrillville, Indiana, 46410, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
Providence Milwaukie Hospital

Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
QEII Health Sciences Centre/Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 2Y9, Canada
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Randolph Hospital

Asheboro, North Carolina, 27203, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Cancer Centers-Greenwood Village

Greenwood Village, Colorado, 80111, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers-Parker

Parker, Colorado, 80138, United States
Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Roper Hospital

Charleston, South Carolina, 29401, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
SSM Health Dean Medical Group - South Madison Campus

Madison, Wisconsin, 53715, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States
Saint Louis-Cape Girardeau CCOP

St Louis, Missouri, 63141, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Southeast Clinical Oncology Research Consortium NCORP

Winston-Salem, North Carolina, 27104, United States
Sovah Health Martinsville

Martinsville, Virginia, 24112, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Sutter Pacific Medical Foundation

Santa Rosa, California, 95403, United States
Swedish American Hospital

Rockford, Illinois, 61104, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Moncton Hospital

Moncton, New Brunswick, E1C 6Z8, Canada
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Medical Center

Moline, Illinois, 61265, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Connecticut

Farmington, Connecticut, 06030, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, 36688, United States
University of Toledo

Toledo, Ohio, 43614, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Veterans Administration

Columbia, Missouri, 65201, United States
Veterans Affairs Medical Center -Washington DC

Washington D.C., District of Columbia, 20422, United States
Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western States Cancer Research NCORP

Denver, Colorado, 80222, United States

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