LYMPHOMA

This study tests whether adding two targeted drugs (glofitamab and polatuzumab) to standard chemotherapy (R-CHP) can improve outcomes for people with high-risk diffuse large B-cell lymphoma. About 41 adults who have not been treated before will receive the combination. The main g…

This study tests a drug called alectinib, already approved for some lung cancers, in people with other rare cancers that have a specific gene change (ALK). About 30 adults, teens, and children will receive the drug to see if it shrinks tumors or stops cancer growth for at least 2…

This study tests whether adding eliglustat (a drug that blocks certain sugar molecules) to standard CD30-targeted immunotherapy can make the treatment work better for people with CD30-positive lymphoma. About 40 adults who have already tried at least one other cancer treatment wi…

This study tests whether a cord blood transplant (using stem cells from donated umbilical cord blood) can help children and young adults up to age 26 with blood cancers like leukemia or lymphoma. Participants receive the transplant as their first or second treatment. The main goa…

This study tests whether the drug loncastuximab tesirine can help control large B-cell lymphoma in people who had only a partial response after CAR T-cell therapy. About 30 adults will receive the drug to see if it can turn a partial response into a complete remission. The goal i…

This study tests a new drug combination (bendamustine, rituximab, cytarabine, and zanubrutinib) as initial treatment for mantle cell lymphoma. After this induction phase, participants receive maintenance therapy with zanubrutinib and rituximab, with or without an additional drug …

This study tests a new drug called NUC-7738 in people with advanced solid tumours or lymphoma that have not responded to other treatments. The goal is to find the safest dose and see if it can shrink tumours, either alone or combined with another drug (pembrolizumab). About 135 a…

This study tests a new way to make immune cells (T cells) that can attack cancer cells infected with the Epstein-Barr virus (EBV). The cells are grown faster in the lab and given to patients with Hodgkin or non-Hodgkin lymphoma, or related diseases that have come back or not gone…

This study tests whether the drug mosunetuzumab, given alone or with zanubrutinib, can effectively treat people who have just been diagnosed with follicular lymphoma and need therapy. About 152 adults with stage II to IV lymphoma will receive the treatment to see if it causes the…

This study tests a combination of five drugs (venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide, called ViPOR) in people whose B-cell lymphoma has returned or not improved after prior treatment. The goal is to see if this drug mix is safe and how well it works. Pa…

This study tests a new drug called MDX2003 in adults with several types of B-cell lymphoma (like DLBCL or follicular lymphoma) that have returned or stopped responding to at least two prior treatments. The main goals are to find the safest dose and check if the drug can shrink tu…

This early-phase study tests whether adding pembrolizumab (an immunotherapy) to standard chemotherapy is safe and effective for people newly diagnosed with primary central nervous system lymphoma, a rare brain cancer. About 15 adults will receive the drug combination. The main go…

This study tests whether the drug mosunetuzumab, given alone or with a BTK inhibitor, can clear tiny amounts of leftover leukemia cells in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who are already on or have recently finis…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will measure heart function and inflammation markers in 104 adults who recently started chemo. The goal i…

This study tests the safety and effectiveness of the drug ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if ponatinib can shrink or control the cancer. About…

This study tests a radioactive drug called Lu-177 edotreotide in children aged 2 to 17 with tumors that have a specific marker (SSTR). The goal is to find the right dose and check if it is safe. About 20 children whose tumors came back or did not respond to prior treatment will t…

This study looks at how well umbilical cord blood stem cells from unrelated donors help patients with serious blood cancers, immune problems, or genetic disorders. About 30 people will receive a transplant to see how quickly their blood cells recover and how often the transplant …

This study tests a drug called pembrolizumab in children aged 6 months to 18 years with advanced melanoma, solid tumors, or lymphoma that has spread, come back, or not responded to treatment. The drug helps the immune system fight cancer. The goal is to see if it can shrink or el…

This study tests whether the drug epcoritamab can help people with follicular lymphoma whose cancer did not completely go away after their first chemotherapy and immunotherapy treatment. About 35 adults with advanced-stage lymphoma will receive epcoritamab as a second treatment. …

This study tests a drug called odronextamab in 35 people with untreated, low-tumor follicular lymphoma. The goal is to see if it can shrink or eliminate cancer without needing standard chemotherapy. Participants receive the drug and are monitored for safety and response.

This study tests whether the immunotherapy drug nivolumab can slow or stop the growth of certain cancers linked to the Epstein-Barr virus. It includes people aged 12 and older whose cancer has not responded to standard treatments. Participants receive nivolumab every two weeks, a…

This study tests a new drug called OSE-279 that helps the immune system fight cancer by blocking a protein called PD-1. It is for people with advanced solid tumors or lymphomas that have not responded to other treatments. The trial has three parts: first finding the safest dose, …

This early study looks at whether eating a magnesium-rich diet and applying magnesium lotion can help keep magnesium levels healthy in people with lymphoma. Magnesium is important for cell health, and low levels are common in sick patients. The study will enroll 60 adults with ly…

This study is for people with blood cancers who need a stem cell transplant from an unrelated donor with a different blood type. The goal is to find which drug combination works best to prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the …

This study compares a new drug called glofitamab against standard treatments (rituximab plus bendamustine or lenalidomide plus rituximab) in about 182 adults with mantle cell lymphoma that has returned or not responded to prior therapy. Participants must have already tried at lea…

This program provides access to tisagenlecleucel (CTL019), a CAR-T cell therapy, for people with serious blood cancers like lymphoma or leukemia who have no other treatment options and cannot join a clinical trial. Doctors must request the therapy for individual patients, and the…

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or stopped responding to prior treatment. About 36 adults with this slow-growing blood cancer will receive the drug combination. The goal is t…

This study tests a combination of two drugs, ZG005 and gecacitinib, in about 60 adults with relapsed or refractory lymphoma (cancer that returned or didn't respond to prior therapy). The first part finds a safe dose; the second part checks if the combo shrinks tumors. Participant…

This study is for adults with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) that has come back or not responded to treatment. Researchers are adding a drug called capivasertib to a standard chemotherapy regimen (mini-hyperCVD plus venetoclax) to see if it is …

This study tests whether adding a short course of radiation to the drug glofitamab can improve outcomes for people with a type of aggressive lymphoma (DLBCL) that has come back or not responded to treatment, especially when the cancer is large. About 40 adults aged 18-75 will rec…

This study is for adults with early-stage marginal zone lymphoma, a slow-growing blood cancer. Researchers want to see if starting with an ultra-low dose of radiation (4 Gy) can control the disease, and only giving a higher dose if needed. The goal is to reduce side effects while…

This study looks at whether lower doses of two blood-thinning pills (apixaban and rivaroxaban) work as well as standard injections to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will be randomly …

This early-phase trial tests a new drug called TLN-121, alone or with other lymphoma treatments, in about 180 adults whose Non-Hodgkin Lymphoma has returned or not responded to prior therapy. The main goals are to check safety, find the right dose, and see if the drug shrinks tum…

This early-phase study tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are modified in the lab to better recognize and attack cancer cells. …

This study tests if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in 60 adults whose immune systems are weakened by certain cancer or autoimmune treatments. Participants must have a confirmed RSV infection with symptoms. The main goal is to see i…

This study tests a targeted drug called duvelisib against two standard chemotherapy drugs (gemcitabine or bendamustine) in people with a rare type of T cell lymphoma that has returned or not responded to prior treatment. About 124 adults will be randomly assigned to receive duvel…

This study tests a new approach using a patient's own immune cells, modified to target two markers (CD19 and CD22) on lymphoma cells, as a first-line consolidation treatment. It is for people with follicular lymphoma who had only a partial response to initial chemotherapy. The go…

This study tests whether fecal microbiota transplantation (FMT) can reduce gut-related side effects from antibiotics in 40 adults with B-cell lymphoma receiving standard CAR-T cell therapy. Participants receive FMT alongside their cancer treatment to see if it improves safety and…

This early-stage study tests a new drug called glofitamab combined with two chemotherapy drugs (gemcitabine and oxaliplatin) in 50 U.S. adults whose diffuse large B-cell lymphoma has come back or stopped responding to treatment. The goal is to see if the combination is safe and c…

This study tests if briefly restricting blood flow to the arm (using a blood pressure cuff) before chemotherapy can prevent heart damage in lymphoma patients. About 608 adults receiving a common type of chemotherapy (anthracyclines) will be randomly assigned to receive the real t…

This study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced cancers that have specific genetic changes (ALK, ROS1, or NTRK). The first part finds the safest dose, and the second part checks if the drug shrinks tumors. About 75 participan…

This study tests whether a new form of the drug carmustine (without ethanol) causes fewer side effects than the standard version in lymphoma patients receiving a stem cell transplant. About 49 adults with Hodgkin or non-Hodgkin lymphoma who are already candidates for transplant w…

This study tests whether combining two drugs, rituximab and venetoclax, can shrink or eliminate tumors in people with untreated marginal zone lymphoma. About 33 participants will receive the treatment to see how many achieve complete remission. The goal is to find a more effectiv…

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This early-stage study tests an experimental drug called LB1410 in people with advanced solid tumors or lymphoma that hasn't responded to standard treatments. The drug is a bispecific antibody designed to target two immune checkpoints (PD-1 and TIM-3) to help the immune system fi…

This study tests the drug pembrolizumab in Japanese children with solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell skin cancer. The main goals are to check the drug's safety, how the body processes it, and whether tumors shrink. About 20 participants wi…

This early-stage trial tests an experimental drug called TLN-254 in about 50 adults with T-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see if the drug can shrink tumors or make them disappear. Researchers will also monitor side effects a…

This study tests a new drug called valemetostat combined with two standard drugs (rituximab and lenalidomide) in people with follicular lymphoma that has returned or not responded to prior treatment. The main goals are to find a safe dose and to see how well the combination works…

This study tests a mix of six drugs (ViPOR-P) in people with B-cell lymphoma that came back or didn't respond to prior treatment. The goal is to see if the combination is safe and can shrink tumors. Up to 55 adults will receive up to six 21-day cycles of oral pills and IV infusio…

This study tests the drug ruxolitinib in people with T or NK cell lymphoma that has come back or not responded to treatment. Ruxolitinib blocks a protein that helps these cancer cells survive, which may shrink the tumors. About 83 adults will take part to see if the drug can cont…

This study tests a one-time infusion of specially engineered immune cells (lisocabtagene maraleucel) as the first treatment for primary central nervous system lymphoma in 65 adults who are not eligible for a stem cell transplant. The goal is to see if this therapy can control the…

This study tests a combination of three drugs—epcoritamab, zanubrutinib, and rituximab—in people with follicular lymphoma or marginal zone lymphoma that has come back or not responded to prior treatment. The goal is to see how well the combo works at shrinking tumors and to check…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This study tests whether a prebiotic (resistant starch) can improve gut microbiome diversity in 30 people with multiple myeloma or lymphoma undergoing autologous stem cell transplant. Participants take the prebiotic or a placebo for about 10 days before and until engraftment. The…

This study will collect MRI scans from 3,000 adults with brain tumors (gliomas, metastases, or lymphoma) to train an artificial intelligence system. The goal is to help doctors identify tumor types more accurately without surgery, potentially reducing the need for biopsies. Parti…

This study tests a new type of PET/CT scan that looks for a protein called CD70 on cancer cells. It aims to better detect kidney cancer, lymphoma, and nasopharyngeal cancer in 300 adults. The scan may help doctors see tumors more clearly and guide treatment decisions.

This study tests a new ultrasound method called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (harmless) and malignant (cancerous) lymph nodes. About 779 adults with abnormal lymph nodes will get this special ultrasound before a bio…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study tests whether the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who are at higher risk due to changes in their T-cells. About 134 participants will receive a limited course of the drug to see if it reduces the virus …

This study tests a home-based exercise and nutrition program for 40 adults with lymphoma or myeloma who are about to receive CAR-T cell therapy. Participants follow a personalized plan using a tablet and get support from a rehab team online. The goal is to see if this approach im…

This study looks at whether a 12-week home exercise program with remote coaching and monitoring can improve heart and lung fitness and daily activity levels in people who have finished treatment for lymphoma. About 80 participants will be randomly assigned to either the home-base…

This study tests an 8-week virtual rehab program (CaRE@Home) for cancer survivors who have finished treatment. It aims to reduce disability and improve physical function, anxiety, and quality of life. About 388 adults with breast, colorectal, head and neck cancer, or lymphoma wil…

This study tests whether a smartphone app that connects young adults (ages 18-40) with trained peer navigators can help them feel more in control of their health after finishing cancer treatment. About 138 people who had breast cancer, testicular cancer, lymphoma, or sarcoma will…

This study tests a drug called eflapegrastim in 40 children with solid tumors or lymphoma who are getting chemotherapy. The drug aims to boost white blood cells, reducing the risk of severe infections. Researchers will monitor safety and how the drug works in the body.

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life priorities with their doctors. About 75 adults will play the game and then fill out advance care planning documents. The …

This study tests whether a one-day hospital visit with medical, psychological, and social support after finishing cancer treatment can improve quality of life for teens and young adults (ages 15-25) with solid tumors or lymphoma. 214 participants will be randomly assigned to rece…

This study tests a program that gives blood cancer patients access to blood transfusions at home while in hospice care. The goal is to see if this improves quality of life, mood, and reduces hospital visits near the end of life. About 700 adults with advanced blood cancers like l…

This study tests a smartphone app called ASSIST that uses artificial intelligence to help people with breast, colorectal, or lymphoma cancer manage symptoms while receiving chemotherapy or other systemic therapy. About 60 adults will be split into two groups: one uses the app for…

This study tests a program called UPLYFT for lymphoma survivors who worry about their cancer returning. It provides information and tools to improve quality of life and reduce anxiety. About 74 survivors who finished treatment 3 to 24 months ago and are in remission will particip…

This study tests a program called GEM-S, which combines a geriatric check-up with health education, to see if it helps older cancer survivors improve their physical abilities, thinking, and memory. About 668 survivors of lymphoma or solid tumors will be assigned to either GEM-S o…

This study is testing whether a 12-week program that encourages lymphoma patients to take frequent breaks from sitting can improve their heart health and reduce side effects from chemotherapy. The program includes supervised activity breaks during infusion appointments and home-b…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. Researchers will enroll 260 people …

This study looks at whether adding palliative care (extra support for symptoms and stress) to usual cancer care can improve quality of life for adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to e…

This study tests whether personalized diet advice from a registered dietitian can reduce fatigue and improve sleep and quality of life in lymphoma survivors. About 100 adults with persistent tiredness will receive 8 counseling sessions over 3 months by phone or video. The goal is…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medicine can reduce the amount of opioids needed after preventive thigh bone surgery. The surgery is for patients with cancer that has spread to the thigh bone but who do not have a broken…

This study is creating a large database of people with various blood diseases in China, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, out…

This study is testing whether collecting cell-free DNA (cfDNA) from blood samples can help identify genetic changes in lymphoma and detect leftover disease after treatment. About 517 adults with diffuse large B-cell lymphoma will give blood samples before and after therapy. The g…

This study looks at how the body processes venetoclax when the tablets are crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured.…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma. Researchers will collect DNA and blood samples from people who have these cancers and their family members. No treatment is given—the goal is to learn more about why…

This study aims to understand how well vaccines work in people with certain blood cancers like chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Participants will receive one or more vaccines (e.g., COVID-19, hepatitis B, shingles) and provide blood samples to measure…

This study tracks memory and thinking changes in 100 adults with blood cancers (like lymphoma or leukemia) who receive whole brain radiation. Researchers will test cognitive skills over time to understand the treatment's effects on the brain. The goal is to learn more, not to tes…

This study looks at how services from Blood Cancer United (formerly The Leukemia & Lymphoma Society) affect people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will track 400 patients over time to see if the organization helps with access to care, quality …

This study is testing a new approach called xDRIVE that combines lab tests on tumor samples with artificial intelligence to suggest personalized cancer treatments. It involves 210 Florida patients with cancers that have come back or not responded to standard therapy, including ch…

This study looks at whether a simple early warning score (based on vital signs like breathing and heart rate) can help doctors spot serious problems early in blood cancer patients receiving strong chemotherapy. About 2,200 adults will take part across 10 hospitals. Half the hospi…

This study aims to understand if CAR T-cell therapy, a treatment for blood cancers like leukemia and lymphoma, can affect thinking skills such as memory and attention in children and young adults aged 5 to 35. Participants will complete thinking tests and questionnaires at home o…

This study tests whether an AI tool can create a personalized list of questions for people with lymphoma or multiple myeloma to use during their doctor appointments. About 40 participants will use the AI-generated list and then report how confident they felt communicating and how…

This study tracks how a stem cell transplant changes the way the body processes medications. Researchers will collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which samples best reflect the patient's own drug-metabolizing genes. The goal is t…

This study tests a new training program called Hematolo-GIST that helps doctors communicate more clearly with patients who have large B-cell lymphoma. The goal is to improve how doctors discuss the diagnosis and plan future care. About 48 people, including doctors and patients, w…

This study follows 475 women with breast cancer or lymphoma to understand how cancer treatments affect their sexual health, fertility, and ability to have children. Participants complete questionnaires and may optionally provide blood samples to measure ovarian function. The goal…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study looks at whether a new blood test (ctDNA) can guide doctors to safely give less chemotherapy to certain patients with a type of lymphoma called DLBCL. About 40 newly diagnosed patients will have their blood tested during standard treatment. If the test shows no cancer …

This study is a long-term observation of 1,000 patients receiving stem cell transplants for blood diseases at a hospital on the Qinghai-Tibet Plateau. Researchers will collect information on patient health, treatment results, and costs to understand how high altitude affects reco…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify what matters most to them and shares that with their doctors. The goal is to see if using PRIME lead…

This study tests whether a smartwatch combined with artificial intelligence can detect early signs of heart damage in people who have had lymphoma or sarcoma. Researchers will monitor 250 survivors over a year using mobile ECGs and the Apple Watch. The goal is to find a simple, c…

This study looks at different types of scans (MRI, PET/MR, and PET/CT) to see which one works best for finding tumors in children and young adults. About 100 participants with solid tumors or suspected tumors will be enrolled. The goal is to compare how well each scan detects tum…

This study watches how older patients (age 60 and up) with certain blood cancers handle standard CAR-T cell therapy and how it changes their daily life and thinking skills. No extra treatment is given—just careful checkups. The goal is to see if patients can complete all planned …

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health behaviors. Researchers will gather feedback from 40 participants to see if the game is easy and enjoy…

This study collects blood or cheek swab samples from people with cancer who are being treated at the National Cancer Institute. Researchers want to learn how genetic differences may affect how the body processes cancer treatments and whether certain genes are linked to side effec…

This study aims to develop a test that combines blood tests, scans, and health checks to predict which lymphoma patients will benefit from CAR T cell therapy. Researchers will enroll 50 adults with relapsed or hard-to-treat B-cell lymphoma who are scheduled for standard CAR T cel…

This study tests whether an AI-powered chatbot can help people with blood cancers (like leukemia or lymphoma) better understand clinical trials and feel more willing to join one. About 196 patients will be randomly assigned to receive either standard information or AI-assisted ed…

This study collects blood, bone marrow, and tissue samples from up to 15,000 people with blood cancers or related disorders. The samples are stored in a central bank for researchers to use in future studies. Participants do not receive any treatment as part of this study. The goa…

This study is creating a large registry of lymphoma patients in Malawi to collect detailed information about the disease and its treatment. Researchers will enroll 800 people with suspected lymphoma, perform biopsies, and follow their health over time. The goal is to better under…

This study looks at lymphoma patients who also develop a serious immune condition called HLH. Researchers will collect data from 2,000 participants to see which treatments and factors help patients live longer. The goal is to find better ways to treat this rare complication.

This study looks at the genetic makeup of tumors from 40 adults with advanced solid tumors or lymphoma. The goal is to use this information to better match patients with early phase clinical trials. Participants provide a tissue sample from a past surgery or biopsy, but no new tr…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…

This study tests a new PET scan that tracks immune cells called CD8+ T cells, which help fight cancer. Ten adults with lymphoma or metastatic solid tumors will get the scan before and after radiation therapy. The goal is to see if radiation brings more immune cells to tumors, not…