LYMPHOMA

This study tests a new COVID-19 vaccine (GEO-CM04S1) in 63 adults with blood cancers like leukemia or lymphoma who have had a stem cell transplant or cell therapy. The goal is to see if this vaccine triggers a stronger immune response than standard mRNA vaccines. Participants wil…

This study looks at how well a pneumonia vaccine (PCV20) works in people who have beaten B-cell lymphoma after treatment with anti-CD20 therapy. Researchers want to see if a single shot or a two-dose booster is better at protecting them from serious infections. About 30 adults wh…

This study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has come back or not responded to other therapies. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells carrying a protein …

This early-phase study tests a new treatment for people with certain types of lymphoma that have not responded to standard therapy or have returned. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells, plus a…

This study tests a daily pill called zanubrutinib for people with cold agglutinin disease, a rare condition where the immune system mistakenly destroys red blood cells, especially in cold weather. The drug aims to stop the abnormal immune cells from attacking red blood cells, pot…

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The T-cells are modified to target cancer cells and include a safety switch that can be turned on to reduce severe side effects. The goa…

This early-phase study tests whether giving acalabrutinib and rituximab followed by brexucabtagene autoleucel (a CAR T-cell therapy) can help control high-risk mantle cell lymphoma in people who have not yet received treatment. About 22 participants will be enrolled. The main goa…

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to lower the risk of graft-versus-host disease, a common complication. The goal is to see i…

This study tests a new drug called ASTX660 in people with advanced solid tumors or lymphomas that have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or control the disease. About 253 adults will take part in this e…

This early-phase study tests whether giving two drugs—dexamethasone (into the spine) and simvastatin (by mouth)—can safely prevent serious brain side effects in adults receiving CAR-T cell therapy for certain types of lymphoma. About 37 people with hard-to-treat B-cell lymphomas …

This study tests the safety of a drug called neratinib in children and teens whose solid tumors, brain tumors, lymphoma, or leukemia have returned or not responded to standard treatments. Researchers are looking for the best dose and watching for side effects. The goal is to see …

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that carr…

This early-stage study tests a new drug called BYON4228, alone or with another drug (rituximab), in people with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has not responded to previous treatments. The main goal is to check safety and find the right dose. Only 17 pa…

This study compares two treatments for a rare type of brain lymphoma: high-dose chemotherapy followed by a stem cell transplant versus standard chemotherapy alone. The goal is to see which approach better delays cancer progression. 113 newly diagnosed patients aged 18-75 are part…

This study tested a stem cell transplant using blood stem cells from a half-matched (haploidentical) donor in 21 people with various blood cancers like leukemia and lymphoma. The goal was to see if this approach could help patients survive and recover without severe side effects.…

This study tests a drug called CPI-613 in people with certain aggressive lymphomas (Burkitt lymphoma or high-grade B-cell lymphoma) that have returned or not responded to prior treatment. About 24 participants aged 12 and older will receive the drug to see if it can shrink or con…

This study tests a drug called brentuximab vedotin in 79 people with CD30-positive skin lymphomas (a type of cancer). The goal is to see if the drug can shrink or control the cancer. Participants receive the drug every 3 weeks, and researchers track how many respond and how long …

This early-phase study tests a new cell therapy for patients with relapsed EBV-positive lymphoma. The treatment uses the patient's own immune cells, modified to resist a tumor's defense mechanism (TGFb) and trained to attack cancer cells. The main goals are to find a safe dose an…

This study tests a stem cell transplant for people with blood cancers like leukemia, lymphoma, or myelodysplasia. Doctors remove certain immune cells from donor stem cells to help the body accept the transplant and reduce harmful side effects. The goal is to see if this approach …

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia (CLL) in 120 adults. Lenalidomide boosts the immune system and blocks tumor blood vessel growth, while rituximab targets and kills cancer cells. The goal is to shrink or st…

This early-phase study tests a combination of three drugs (rituximab, bendamustine, and melphalan) followed by a stem cell transplant using the patient's own cells. The goal is to see if this gentler regimen causes fewer severe side effects than standard treatments in older adult…

This study was designed to see if combining three drugs—epcoritamab, lenalidomide, and tafasitamab—could safely and effectively treat people with diffuse large B-cell lymphoma (DLBCL) that had come back or stopped responding to treatment. The trial was withdrawn before enrolling …

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease. About 313 adults with various blood cancers…

This early-phase study tests the safety and best dose of a drug called copanlisib combined with immunotherapy drugs (nivolumab, with or without ipilimumab) in adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The goal is to find a dose t…

This early-phase study tests whether adding N-acetylcysteine (N-AC) to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. The goal is to find the best dose of N-AC that causes few or mild side effects. Only 9 participants are enrolled, and the study is activ…

This study tests whether giving radiation and chemotherapy at the same time can better control stage I or II nasal NK cell lymphoma. About 26 newly diagnosed adults will receive both treatments together. The goal is to see if this approach improves how long the disease stays unde…

This study tests new combinations of drugs for people with aggressive B-cell lymphoma that has returned or not responded to standard therapy. About 129 participants will receive either a new drug combo or the usual treatment to see which works better at shrinking tumors. The goal…

This study tested the drug pembrolizumab in 18 people with aggressive lymphomas or rare immune cell cancers that had come back or not responded to other treatments. The goal was to see if the drug could shrink tumors. The trial was suspended, so results are limited.

This study was designed to see if adding tazemetostat to standard CHOP chemotherapy could improve outcomes for people with untreated peripheral T cell lymphoma. It was withdrawn before any participants enrolled, so no results are available. The goal was to increase the number of …

This early-phase study tests a personalized cell therapy for children and young adults with a type of leukemia that has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize two markers (CD19 and CD22) on leukemi…

This study tests an experimental drug called BGB-11417 in 100 adults whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to other treatments. The goal is to see if the drug can shrink or eliminate cancer cells. Particip…

This study tests a new drug called glofitamab added to standard chemotherapy (R-CHOP) for people with a high-risk type of lymphoma (DLBCL) who have not been treated before. The goal is to see if the combination is safe and helps more patients achieve complete remission. About 46 …

This early-phase study tests a new radioactive drug called F-Glutamine, used with PET scans to see if it can find tumors in people with solid cancers or lymphoma. About 67 participants will receive a tiny injection of F-Glutamine, and researchers will measure how long it stays in…

This study tests whether a probiotic called Lactobacillus plantarum can prevent a serious gut condition called graft-versus-host disease (GvHD) in children receiving a donor stem cell transplant. About 173 children with blood cancers or other blood disorders are taking part. The …

This study tests whether a mind-body program (meditation and relaxation) can improve quality of life in teens and young adults (ages 18-39) recently diagnosed with lymphoma. Participants will practice the program and report on their mood, stress, and daily experiences. The goal i…

This study looks at whether fasting for 24 hours before and after chemotherapy is safe and doable for people with lymphoma. About 40 patients will either fast or receive standard care. Researchers will track side effects, weight changes, and quality of life to see if fasting help…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. The goal is to see if remote monitoring and home support can reduce emergency room visits and hospital stays. About 300 adults with certain cancers (like pancreat…

This study looks at whether a special fencing program can help adults with leukemia or lymphoma stay physically active while receiving strong treatments in the hospital. The program is designed to be done in bed, in a chair, or standing up, and aims to reduce muscle weakness and …

This study tests a new way to calculate the dose of melphalan chemotherapy for lymphoma patients getting a stem cell transplant. Instead of a standard dose based on height and weight, researchers use a model that considers how previous patients processed the drug, aiming for the …

This study looks at whether a 12-week program of online chair-based exercise and health education, along with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if this approach is practical and helps improve physical…

This study tests whether giving radiation over a shorter time (instead of the usual 5-6 weeks) is safe for people with lymphoma that has returned or not responded to treatment. About 30 participants will receive different shortened radiation doses to find the safest one. The goal…

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study looks at whether cognitive behavioral therapy (CBT) can help people with acute myeloid leukemia (AML) or lymphoma who feel very tired from their cancer or treatment. About 48 patients will take part in up to 7 counseling sessions to learn new ways to cope with fatigue.…

This study tracks 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. The goal is to watch for long-term side effects and safety issues over 15 years. No new treatment is given—just regular check-ups to see how patients are doing.…

This study follows nearly 90,000 farmers, their spouses, and children in Iowa and North Carolina to see how pesticides and other farm exposures affect their health. Researchers track who develops cancer or other diseases over many years. The goal is to find out which chemicals or…

This study collects white blood cells from people with leukemia or lymphoma whose cancer has not been cured by standard treatments. The cells are stored and may later be used to create a personalized therapy called CAR T-cells. The goal is to make it easier for patients to get th…

This study looks at whether a commercial genomic test can quickly provide useful information for treating diffuse large B-cell lymphoma. About 111 adults with this type of lymphoma will take part. The main goal is to see if test results are available within 7 days, which could he…

This study compares a new total-body PET/CT scanner (uEXPLORER) to conventional PET/CT scanners in 180 adults with lung cancer, lymphoma, or melanoma. The goal is to find the shortest scan time on the new scanner that still produces images as clear as the standard scan. Participa…

This study looks at whether a special website can help women with cancer make better decisions about preserving their ability to have children after treatment. About 130 women with breast, colorectal, or reproductive cancers, or lymphoma, will use the website or receive usual car…

This observational study follows about 1,000 people with CD30-positive lymphoma who are already receiving or about to receive brentuximab vedotin as part of their normal care. Researchers will track side effects and how the drug is used in everyday practice. No experimental treat…

This study was designed to track immune system recovery and test a pneumococcal vaccine (PCV-21) in people receiving CAR-T therapy for blood cancers or solid tumors. Participants would have had regular clinic visits and blood tests for up to 24 months. However, the study was with…

This study planned to look back at medical records to see how often people with lymphoma also had another cancer within six months. It aimed to find patterns and possible causes. The study was withdrawn before any patients were enrolled, so no results are available.

This study collects blood and tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to find genes and proteins linked to cancer. The goal is to better understand why some patients develop complications or have differ…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study looks at whether a daily mindfulness app can help adult survivors of childhood leukemia or lymphoma cope with stress. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs. The goal is to see if this approach is practical and …

This study tracks over 1,400 breast cancer and lymphoma patients to see how chemotherapy affects memory, attention, and thinking skills. Participants are tested before treatment, after treatment, and during follow-ups. The goal is to better understand who is most at risk for cogn…