LYMPHOMA

This study is testing whether a new COVID-19 vaccine called GEO-CM04S1 can trigger a stronger immune response than the standard mRNA vaccines in a particularly vulnerable group. It involves 63 adults with blood cancers (like leukemia or lymphoma) who have received a stem cell tra…

This study is testing a drug called pembrolizumab for people with rare, aggressive cancers of the immune system (like certain lymphomas and histiocyte/dendritic cell sarcomas) that have come back or not responded to standard treatments. The drug works by helping the body's own im…

This study is testing whether adding an over-the-counter antioxidant called N-Acetylcysteine (NAC) to a powerful cell therapy (Yescarta) is safe for people with lymphoma. The main goal is to find the highest dose of NAC that causes few or mild side effects when given alongside th…

This is a first-in-human study to test the safety of a new type of engineered immune cell therapy for adults with specific lymphomas that have returned or not responded to prior treatments. Researchers modify a patient's own T-cells to better recognize and attack cancer cells car…

This study aimed to see if adding the drug tazemetostat to standard CHOP chemotherapy could be more effective for people newly diagnosed with certain types of T cell lymphoma. The trial planned to enroll about 24 adults and measure how well the combination worked to eliminate the…

This study is testing whether combining the drugs lenalidomide and rituximab can help control chronic lymphocytic leukemia (CLL), a type of blood cancer. It will involve about 120 adults with CLL who are either starting treatment for the first time or have had prior therapy. The …

This trial is testing a stem cell transplant method that uses donors who are not a perfect genetic match. It aims to help adults and children with various blood cancers, like leukemia and lymphoma, when a fully matched donor isn't available. The study will see if this approach, w…

This study is comparing two different treatment strategies for a rare type of brain cancer called primary CNS B-cell lymphoma. It aims to see if a more intensive approach using high-dose chemotherapy followed by a stem cell transplant is more effective at keeping the cancer from …

This study is testing whether the drug zanubrutinib can help control cold agglutinin disease, a rare condition where the immune system attacks red blood cells, causing anemia and painful reactions to cold. The trial will enroll about 25 adults who have not responded well to other…

This study is testing an experimental drug called CPI-613 in people with aggressive types of lymphoma or leukemia that have come back or stopped responding to standard treatments. The main goal is to see if the drug is safe and can help shrink the cancer. The trial is for adults …

This study is testing a drug called neratinib in children and young adults whose solid tumors, brain tumors, lymphoma, or leukemia have returned or did not respond to standard treatments. The main goals are to find a safe dose and see what effects, both good and bad, the drug has…

This early-stage study is testing the safety of a new type of personalized cell therapy for adults with B-cell lymphoma that has come back or not responded to other treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to better target cancer, and …

This study is testing new combinations of cancer drugs to see if they work better than the current standard treatment for aggressive B-cell lymphoma that has come back or stopped responding to initial therapy. About 129 patients will be randomly assigned to receive either a new d…

This early-stage study is testing a new type of personalized immune cell therapy for children and young adults with a specific type of leukemia that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to…

This study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…

This study tested whether the drug brentuximab vedotin could help control three types of CD30-positive skin lymphomas in patients whose disease had come back or did not respond to prior treatments. The drug is designed to find and enter cancer cells with a specific marker (CD30) …

This study is testing a new cell therapy for people whose Hodgkin's or Non-Hodgkin's lymphoma has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them back into th…

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This study is testing a new oral drug called ASTX660 in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The main goals are to find the safest and most effective dose and to see if the drug can help control the cancer. The trial i…

This study is testing whether adding an experimental drug called glofitamab to standard chemotherapy (R-CHOP) works better for people with high-risk, untreated diffuse large B-cell lymphoma. Researchers will enroll about 46 patients who have specific high-risk markers in their bl…

This early-stage study is testing a new combination of chemotherapy drugs (RBM) given before a patient's own stem cells are transplanted back into them. The goal is to see if this regimen is safer and has fewer severe side effects than the standard treatment for older adults (age…

This study is exploring whether fasting for 24 hours before and after chemotherapy is safe, practical, and acceptable for people with Hodgkin or Diffuse Large B-Cell Lymphoma. Researchers will compare 40 patients who fast to those who follow standard care, tracking side effects, …

This study is testing a new, personalized way to calculate the dose of melphalan chemotherapy given to lymphoma patients before a stem cell transplant. Instead of using a standard dose based on height and weight, researchers are using a mathematical model to calculate an optimal …

This is an early-stage safety study testing a new type of cell therapy for adults with certain recurring B-cell blood cancers (like lymphoma, myeloma, or CLL) that have not responded to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify t…

This study is testing whether a shorter course of radiation treatment is safe for adults whose Hodgkin or non-Hodgkin lymphoma has returned or not responded to standard treatments. Instead of the usual 5-6 weeks of radiation, researchers aim to find the highest safe dose that can…

This trial is testing a modified stem cell transplant for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Doctors use a special process to remove certain immune cells from the donor's stem cells before the transplant. The goal is to …

This is the first study in people testing a new immune-boosting drug called BYON4228, both alone and combined with an existing lymphoma drug (rituximab). It aims to find safe doses and see if it helps patients whose B-cell non-Hodgkin's lymphoma has returned or hasn't responded t…

This study is testing a new cell therapy for children and young adults (up to age 30) whose leukemia or lymphoma has returned or not responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to recognize a protein called CD22 on canc…

This study is testing a specific type of stem cell transplant for patients with various blood cancers. It uses stem cells from a partially matched family donor instead of bone marrow. The main goals are to see how well patients survive and recover, and to learn how the immune sys…

This early-stage study is testing whether giving two existing drugs—dexamethasone (into the spine) and simvastatin (a pill)—can safely prevent or reduce serious brain-related side effects in adults with lymphoma receiving a powerful treatment called CAR-T cell therapy. The main g…

This study is testing a new cell therapy for lymphoma that has come back after treatment and is linked to Epstein-Barr virus (EBV). Researchers are giving patients special immune cells (T cells) that have been genetically modified to resist a substance released by the tumor and t…

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This early-phase study is testing a three-step treatment for people newly diagnosed with a high-risk form of mantle cell lymphoma, a type of blood cancer. First, patients receive two drugs (acalabrutinib and rituximab), followed by an infusion of their own genetically modified im…

This early-phase study is testing the safety and best doses of combining the cancer drug copanlisib with immunotherapy drugs (nivolumab alone or with ipilimumab). It involves 64 adults with advanced solid tumors or lymphoma that have progressed after standard treatments. The goal…

This study is testing an experimental drug called BGB-11417 in adults whose chronic lymphocytic leukemia or small lymphocytic lymphoma has returned or stopped responding to standard treatments. The trial aims to see how well the drug controls the cancer and how safe it is for pat…

This study is testing a new type of PET/CT scanner called uEXPLORER that can image the entire body at once. Researchers want to see if this new scanner can produce equally clear pictures of cancers (lung cancer, lymphoma, and melanoma) in a much shorter scan time compared to stan…

This study is testing whether a specific probiotic (Lactobacillus plantarum) can prevent a serious complication called acute graft-versus-host disease (GvHD) in children, teens, and young adults receiving a donor stem cell transplant. GvHD happens when the new donor cells attack …

This study is testing whether giving two doses of a pneumonia vaccine works better than one dose for people who have survived B-cell lymphoma. The goal is to see which approach gives stronger, longer-lasting protection against serious lung infections. The study involves 30 adults…

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This study is testing whether a mind-body program, focused on meditation, can help young adults (ages 18-39) recently diagnosed with lymphoma feel better. It aims to see if the program reduces distress, anxiety, and depressive symptoms, and improves overall quality of life. Parti…

This study is testing a phone-based support program designed to help patients with advanced cancer and their family caregivers. The program focuses on improving communication, managing difficult emotions, and reducing caregiver stress. It offers a culturally tailored version for …

This study is testing whether a specially adapted fencing exercise program is practical and helpful for adults with leukemia or lymphoma who are receiving intensive treatment in the hospital. Researchers want to see if this unique form of physical activity can help patients maint…

This study is testing whether a daily mindfulness meditation app is a practical and helpful way for adult survivors of childhood leukemia or lymphoma to manage stress. Fifty participants will use the Headspace app for 30 days, wear a wrist device to measure stress signals, and an…

This study is testing whether a type of talk therapy, delivered over the phone, can help patients with acute myeloid leukemia (AML) or lymphoma manage severe, long-lasting cancer-related fatigue. The therapy focuses on teaching patients skills to change unhelpful thoughts and beh…

This study is testing whether detailed genetic testing can be a practical tool for guiding treatment decisions in lymphoma. Researchers will analyze tumor DNA and RNA from 111 adult patients to see how quickly results can be provided and if they point to specific, targeted therap…

This study is testing a special website designed to help young women recently diagnosed with cancer make decisions about preserving their fertility. The goal is to see if the website reduces the stress and uncertainty of these choices by providing clear information. Researchers a…

This study collects white blood cells from people with certain leukemias or lymphomas that have not been cured by standard treatments. The cells are collected through a 4-6 hour blood filtering process called leukapheresis and then frozen. The goal is to have these cells ready an…

This study aims to understand how chemotherapy affects memory, focus, and thinking skills in people with breast cancer or lymphoma. Researchers will follow over 1,400 patients and healthy volunteers, testing their cognitive function before, right after, and for years following tr…

This is a long-term observational study designed to understand if exposures common in farming—like pesticides, fuels, and dust—increase the risk of developing cancer and other diseases. It follows nearly 90,000 licensed pesticide applicators and their families in Iowa and North C…

This is the first time researchers are testing a new experimental imaging tracer called F-Glutamine in people. The study aims to see how long the tracer stays in the blood and where it goes in the body after injection. If successful, future studies will test if scans using this t…

This study is testing whether a special exercise program is safe and practical for older adults with blood cancers before they receive CAR-T cell therapy. Researchers want to see if patients can stick with the program and if it helps improve their strength and fitness. The goal i…

This study aims to collect real-world information on the safety and effectiveness of the drug brentuximab vedotin for patients with CD30-positive lymphoma. It will follow about 1000 patients in China who are already receiving this treatment as part of their standard care. The goa…

This study aimed to look back at past medical records to see if people diagnosed with lymphoma were more likely to also be diagnosed with another type of cancer at the same time. Researchers planned to analyze data from 2007 to 2012 to understand how often this happens and descri…

This study aims to collect tissue and blood samples from people who have received or donated bone marrow transplants for blood cancers like leukemia and lymphoma. Researchers will analyze these samples to better understand why complications happen and how to improve transplant su…