LEUKEMIA

This study tests whether adding the drug quizartinib to standard chemotherapy helps adults with a specific type of acute myeloid leukemia (AML) live longer. About 700 people aged 18 to 70 with newly diagnosed FLT3-ITD negative AML will receive either quizartinib or a placebo alon…

This study tests whether adding a new drug called roginolisib to two standard drugs (venetoclax and rituximab) is safe and works better for people with CLL that has come back or not responded to prior treatments. About 64 adults who have already tried at least two other therapies…

This early-phase study tests the safety of giving special immune cells (CIML NK cells) along with a standard drug (venetoclax) to adults with acute myeloid leukemia (AML). The treatment aims to help the body's natural killer cells fight leukemia more effectively. About 10 partici…

This study tests a long-acting antibiotic called dalbavancin to prevent bacterial bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days. The goal is to see if it…

This study tests whether a combination of three drugs—cladribine, low-dose cytarabine, and decitabine—can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) in patients aged 60 and older (or younger if not fit for standard chemo). The goal is to…

This study compares different infection prevention strategies in 900 people with blood cancers like myeloma, lymphoma, and leukemia. The goal is to find which approach is safest and most effective at preventing serious infections. Participants will receive one of several treatmen…

This study tests whether a cord blood transplant (using stem cells from donated umbilical cord blood) can help children and young adults up to age 26 with blood cancers like leukemia or lymphoma. Participants receive the transplant as their first or second treatment. The main goa…

This study tests a drug called revumenib in people with certain types of leukemia that have not responded to standard treatment. The drug works by blocking a protein called menin, which may help control the disease. About 40 people aged 12 and older will take part to see if the d…

This early-phase trial tests a new treatment called CD19 t-haNK for people with a type of blood cancer (B-cell acute lymphoblastic leukemia) that has come back after prior treatments. Up to 10 participants will receive the therapy to see if it is safe and shows signs of working. …

This early-phase study tests whether specially trained immune cells (CIML NK cells) given after a stem cell transplant can safely prevent leukemia or related blood cancers from coming back. About 15 adults with high-risk acute myeloid leukemia, myelodysplastic syndrome, or relate…

This study tests whether a time-limited combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—is safe and effective for people with chronic lymphocytic leukemia (CLL) or Richter transformation (RT) who have not had prior treatment. About 60 adults will take part.…

This study tests whether adding a specific type of immune cell (memory T cells) after a stem cell transplant can help prevent serious viral and fungal infections. About 100 children and young adults with blood cancers, immune disorders, or bone marrow failure will receive this ex…

This early-stage study tests a new daily pill, BH-30236, in adults whose acute myeloid leukemia or high-risk myelodysplastic syndrome has returned or stopped responding to other treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink ca…

This study tests whether the drug mosunetuzumab, given alone or with a BTK inhibitor, can clear tiny amounts of leftover leukemia cells in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who are already on or have recently finis…

This study tests a combination of chemotherapy drugs and targeted therapies for children and young adults with B-cell acute lymphocytic leukemia that has come back or not responded to treatment. The goal is to see if this new mix can control the disease and what side effects it m…

This early-phase trial tests a new drug called revumenib added to standard chemotherapy and a targeted therapy (midostaurin) for people with a specific genetic type of acute myeloid leukemia (AML). The goal is to find a safe dose and see how well it works to put the cancer into r…

This early-phase study tests a new drug called CG009301 in adults with blood cancers (like leukemia or MDS) that returned or didn't respond to standard treatments. The main goals are to find a safe dose and see if the drug can help control the disease. About 45 participants will …

This early-phase study tests the safety and tolerability of a new drug called Karonudib in adults with blood cancers like leukemia who have exhausted standard treatments. The goal is to find a safe dose and look for early signs that the drug might help control the disease. Only 9…

This study tests a stem cell transplant method for people under 25 with certain blood cancers. The approach filters out specific immune cells from donated stem cells to lower the risk of graft-versus-host disease (a serious complication) while helping the new cells grow. Up to 40…

This study tests a new combination of three drugs (cyclophosphamide, tacrolimus, and ruxolitinib) to prevent graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancers like leukemia. The goal is to see if this approach can reduce severe GVHD and…

This early-stage study tests a new drug called ziftomenib combined with standard treatments for people with a type of acute myeloid leukemia (AML) that has come back or not responded to therapy. The main goal is to check safety and find the best dose. About 171 adults with specif…

This study tests the safety and effectiveness of the drug ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if ponatinib can shrink or control the cancer. About…

This study is testing a new drug, MP0533, in about 249 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. The goal is to find the safest dose and see if the drug can help control the cancer. Participants wi…

This study tests a new combination of drugs for people with acute myeloid leukemia (AML) whose cancer did not respond to or came back after standard treatment. About 30 adults will receive mitoxantrone along with venetoclax and azacitidine to see if this mix can shrink the cancer…

This program provides access to tisagenlecleucel (CTL019), a CAR-T cell therapy, for people with serious blood cancers like lymphoma or leukemia who have no other treatment options and cannot join a clinical trial. Doctors must request the therapy for individual patients, and the…

This study is for adults with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) that has come back or not responded to treatment. Researchers are adding a drug called capivasertib to a standard chemotherapy regimen (mini-hyperCVD plus venetoclax) to see if it is …

This program provides stem cell transplants for up to 100 children and young adults with life-threatening blood or immune system diseases who do not have a perfectly matched sibling donor. The transplant uses a special technique to remove certain immune cells from the donated ste…

This study looks at whether lower doses of two blood-thinning pills (apixaban and rivaroxaban) work as well as standard injections to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will be randomly …

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people whose acute leukemia has returned or not responded to prior treatment. It includes adults and teens aged 12+ with specific genetic subtypes (KMT2A-r, NUP98-r, or NPM1-m). The first part fi…

This early-phase study tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are modified in the lab to better recognize and attack cancer cells. …

This study looks at whether it is safe to stop antibiotics early in adults with high-risk blood cancers or those who have had stem cell transplants or CAR T-cell therapy. Participants will be randomly assigned to stop antibiotics once their fever goes away or continue until their…

This study tests two different doses of quizartinib as a maintenance treatment for adults with a specific type of acute myeloid leukemia (FLT3-ITD positive) who are in their first complete remission and have not had a stem cell transplant. The goal is to see which dose is safer a…

This study looks at different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin therapy to see which approach works better at keeping them infection-free. …

This early-stage study tests whether combining two drugs, venetoclax and Vyxeos, is safe for children, teens, and young adults (ages 1 to 39) with acute leukemia that has returned or not responded to prior therapy. The main goal is to find the best dose with manageable side effec…

This early-phase study tests whether a new treatment called BiTE-EV is safe and can help adults with relapsed or hard-to-treat acute B-cell leukemia. Only 3 participants will receive the therapy every other day for 1-2 months and be followed for side effects and treatment respons…

This study tests a combination of three drugs (tagraxofusp, azacitidine, and venetoclax) in adults with acute myeloid leukemia (AML) who are in remission but still have tiny amounts of cancer cells that can't be seen under a microscope. The goal is to see if the treatment can saf…

This study looks at different ways to prevent infections in people with blood cancers like myeloma, leukemia, and lymphoma. It compares treatments such as antibiotics and immunoglobulin therapy to see which works best. About 900 participants will be enrolled, and the goal is to r…

This study tests a modified, lower-dose chemotherapy for adults with acute lymphoblastic leukemia who are too frail for standard treatment. The goal is to improve survival and reduce severe side effects. About 45 participants will receive an adjusted regimen designed to be better…

This early-phase trial tests a new treatment for children and adults with acute leukemia that has come back or not responded after a donor stem cell transplant. The treatment uses specially engineered immune cells (T cells) from the original donor that are trained to recognize an…

This study tests a second type of CAR T-cell therapy (CD22 CAR T) for children and young adults whose B-cell leukemia came back after standard CD19 CAR T treatment. About 20 participants will receive the new cells 28 to 42 days after the first therapy. The main goals are to check…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study compares two common treatments—immunoglobulin and antibiotics—to see which is better at preventing serious infections in people with blood cancers like myeloma, lymphoma, or leukemia. About 900 adults will take part. The goal is to find the safest and most effective wa…

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life priorities with their doctors. About 75 adults will play the game and then fill out advance care planning documents. The …

This study tests a program that gives blood cancer patients access to blood transfusions at home while in hospice care. The goal is to see if this improves quality of life, mood, and reduces hospital visits near the end of life. About 700 adults with advanced blood cancers like l…

This study tests whether people with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program that teaches healthier eating and more physical activity. About 30 adults will take part. The main goal is to see if at least 70% of participants can comp…

This study looks at whether adding palliative care (extra support for symptoms and stress) to usual cancer care can improve quality of life for adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to e…

This study looks at whether adding guided spiritual care sessions to standard hospital care is possible and helpful for adults with acute leukemia. About 70 participants will be randomly assigned to either receive these sessions or usual care. The goal is to see if patients accep…

This study is a long-term observation of 1,000 patients receiving stem cell transplants for blood diseases at a hospital on the Qinghai-Tibet Plateau. Researchers will collect information on patient health, treatment results, and costs to understand how high altitude affects reco…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify what matters most to them and shares that with their doctors. The goal is to see if using PRIME lead…

This study is creating a large database of people with various blood diseases in China, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, out…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study looks at how the body processes venetoclax when the tablets are crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured.…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma. Researchers will collect DNA and blood samples from people who have these cancers and their family members. No treatment is given—the goal is to learn more about why…

This study looks at whether a tailored exercise program can slow down the aging process in people aged 50 and older who have survived blood cancers like leukemia or lymphoma. Researchers want to find out how much and what type of exercise is needed to make a difference. The goal …

This study tracks memory and thinking changes in 100 adults with blood cancers (like lymphoma or leukemia) who receive whole brain radiation. Researchers will test cognitive skills over time to understand the treatment's effects on the brain. The goal is to learn more, not to tes…

This study looks at how services from Blood Cancer United (formerly The Leukemia & Lymphoma Society) affect people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will track 400 patients over time to see if the organization helps with access to care, quality …

This study looks at whether a simple early warning score (based on vital signs like breathing and heart rate) can help doctors spot serious problems early in blood cancer patients receiving strong chemotherapy. About 2,200 adults will take part across 10 hospitals. Half the hospi…

This study aims to understand if CAR T-cell therapy, a treatment for blood cancers like leukemia and lymphoma, can affect thinking skills such as memory and attention in children and young adults aged 5 to 35. Participants will complete thinking tests and questionnaires at home o…

This study looks at whether firefighters' exposure to dangerous chemicals on the job raises their risk of developing blood cancers. Researchers will test blood samples from 300 firefighters in Charlotte, NC, for early signs of cancer, such as abnormal blood cells or proteins. The…

This study interviews Spanish-speaking families of children with leukemia or lymphoma to understand their experiences and satisfaction with care. The goal is to identify common needs and barriers caused by language differences, and to explore interest in a home telemedicine suppo…

This study tracks how a stem cell transplant changes the way the body processes medications. Researchers will collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which samples best reflect the patient's own drug-metabolizing genes. The goal is t…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health behaviors. Researchers will gather feedback from 40 participants to see if the game is easy and enjoy…

This study is a large registry that gathers medical information and biological samples from 10,000 adults with acute lymphoblastic leukemia (ALL) and similar blood cancers. The goal is to track how patients are diagnosed, treated, and how they fare over time, in order to improve …

This study is testing a web-based tool called TRIAL that provides information and resources about acute leukemia and clinical trials. Researchers want to see if the tool is easy to use and if people will complete the follow-up surveys. The study involves 75 adults with suspected …

This study aims to find inherited gene changes that increase the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Researchers will use advanced DNA sequencing to test affected and healthy family members. The goal is to discover new or known mutations that…

This study looks at how air pollution particles get into the bodies of non-smokers who have lung cancer, COPD, or leukemia. Researchers will compare these patients with healthy volunteers to find new markers that show how pollution causes disease. The goal is to better understand…

This study aims to better understand chronic myelomonocytic leukemia (CMML) by collecting blood and bone marrow samples from 5,000 adults. Researchers will analyze these samples to improve diagnosis, predict disease progression, and identify new treatment options. Participants ar…

This study collects blood, bone marrow, and tissue samples from up to 15,000 people with blood cancers or related disorders. The samples are stored in a central bank for researchers to use in future studies. Participants do not receive any treatment as part of this study. The goa…