LEUKEMIA

This study tested whether the drug dasatinib can help control chronic lymphocytic leukemia (CLL) in 17 people who had already tried other treatments. Researchers measured how many patients had their cancer shrink or disappear. The goal was to manage the disease, not cure it.

This early-phase study tested the drug enasidenib in 17 adults with lower-risk myelodysplastic syndrome (MDS) or a related leukemia (CMML) who did not have a specific gene mutation (IDH2). The goal was to see if the drug could safely improve anemia and reduce the need for blood t…

This study tested a two-step stem cell transplant for people with high-risk blood cancers like leukemia and lymphoma. The approach uses a drug called cyclophosphamide to lower the chance of graft-versus-host disease (GVHD), a serious side effect. The goal was to help more patient…

This study tested a combination of three chemotherapy drugs (thiotepa, fludarabine, and melphalan) given before a donor stem cell transplant for people with leukemia. The goal was to see if this regimen could help patients stay cancer-free for at least one year after transplant. …

This study tested a new way to prepare people with hard-to-treat acute leukemia for a donor stem cell transplant. It combined a precise type of radiation (IMRT) with two chemotherapy drugs (etoposide and cyclophosphamide) to kill cancer cells and help the donor cells take hold. T…

This study tested a combination of chemotherapy drugs in 318 adolescents and young adults (ages not specified) with newly diagnosed acute lymphoblastic leukemia (ALL). The goal was to see how well the treatment worked at killing cancer cells and stopping the disease from coming b…

This study looked at 800 children with acute lymphoblastic leukemia (ALL) to compare two forms of the drug asparaginase: a pegylated version given through a vein and a standard version given as a shot. The goal was to see which caused fewer serious side effects like allergic reac…

This study tested a drug called ruxolitinib, which blocks certain cancer-driving proteins, combined with standard chemotherapy in 171 children and young adults with a high-risk type of acute lymphoblastic leukemia (ALL). The goal was to find the best dose and see if the combinati…

This study tested a treatment for adults with acute myeloid leukemia (AML) who were in their first remission. Patients received high-dose chemotherapy and radiation, followed by a transplant of their own previously collected stem cells, plus an immune-boosting drug after transpla…

This study tested a new pill called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. The goal was to see if it could shrink enlarged spleens and reduce the need for blood transfusions. The drug was given alone or with another medicine (ruxoli…

This study tested a new way to help people with blood cancers like leukemia and lymphoma get hospice care earlier. Normally, patients delay hospice because they need blood transfusions for symptom relief, but hospices can't afford to provide them. The study paid for transfusions …

This study looked at nearly 1,900 male farmers over age 50 to see if pesticides are linked to early signs of blood cancers like multiple myeloma. Researchers collected blood and urine samples and asked about pesticide use. No treatment was given—the goal was simply to gather info…

This study looked back at 30 people with HIV who were treated with CAR T-cell therapy for certain blood cancers like lymphoma or leukemia. Researchers collected standard medical data to see how often side effects occurred and how the immune system changed over time. The goal was …

This study looked at whether pesticides in homes or farms increase the risk of childhood leukemia. Researchers collected carpet dust and mapped nearby crops for 629 children in California. The goal was to see if certain chemicals are linked to higher leukemia rates.

This study looked at genetic information from over 1,300 stored samples of lymphoma, leukemia, and multiple myeloma to find new ways to classify these cancers. Researchers wanted to understand why some patients respond well to treatment while others do not. No new patients were r…

This study followed 44 adults with leukemia or lymphoma who received CAR T-cell therapy to see how their hearts were affected. Researchers used heart scans, blood tests, and quality-of-life surveys to track heart function over time. The goal was to find out how often heart proble…

This completed study looked at 126 adults aged 60 and older who had a bone marrow transplant for blood cancers like leukemia or lymphoma. Researchers measured physical abilities, mental health, and stress levels before and after transplant to find traits that help people recover …

This study tested a program designed to help adolescent and young adult cancer survivors (ages 15-39) find healthcare resources, learn self-care skills, and get support. The goal was to see if the program could reduce cancer-related distress and help survivors follow recommended …

This study looked at whether a home-based exercise program is practical for people aged 65 and older with lymphoma, leukemia, or myeloma who are about to receive CAR-T cell therapy. Twenty participants were asked to do supervised resistance training and moderate aerobic exercise.…

This study looked at whether a peer support group is practical and helpful for young adults (ages 18-39) who have had a stem cell transplant. Thirteen participants joined the program, and researchers measured how acceptable and useful it was. The goal was to see if this kind of s…