LEUKEMIA

This study tests a new COVID-19 vaccine (GEO-CM04S1) in 63 adults with blood cancers like leukemia or lymphoma who have had a stem cell transplant or cell therapy. The goal is to see if this vaccine triggers a stronger immune response than standard mRNA vaccines. Participants wil…

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This study tests a new approach for people with leukemia or myelodysplastic syndromes (MDS) who need a donor stem cell transplant. Before the transplant, patients receive a special type of radiation (helical tomotherapy) along with two chemotherapy drugs (fludarabine and melphala…

This study tests a drug called CPI-613 in people with certain aggressive lymphomas (Burkitt lymphoma or high-grade B-cell lymphoma) that have returned or not responded to prior treatment. About 24 participants aged 12 and older will receive the drug to see if it can shrink or con…

This study looks at whether using stem cells from a younger, more distant relative leads to better survival than using cells from an older immediate family member for people with leukemia or myelodysplastic syndrome (MDS). About 232 patients aged 13-78 who need a transplant but l…

This study tests a combination of two drugs, vemurafenib (a pill) and obinutuzumab (given by IV), in 30 people with untreated hairy cell leukemia. The goal is to see how many patients achieve a complete response (no signs of cancer). Participants take vemurafenib for 4 months and…

This study tests a stem cell transplant for people with blood cancers like leukemia, lymphoma, or myelodysplasia. Doctors remove certain immune cells from donor stem cells to help the body accept the transplant and reduce harmful side effects. The goal is to see if this approach …

This study tests whether a chemotherapy plan used for children with acute lymphoblastic leukemia (ALL) is safe and works well for adults aged 18 to 60 with a specific type of ALL (Ph-negative). The goal is to see if this approach can clear the disease from the bone marrow. About …

This study tests a new approach for people with relapsed or chemotherapy-resistant B-cell cancers like chronic lymphocytic leukemia and indolent B-cell lymphoma. Researchers take a patient's own T cells (a type of immune cell), modify them in the lab to target a protein called CD…

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that carr…

This study tests an experimental drug called AZD6738 in adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease got worse after standard therapy. The main goal is to check the drug's safety and find the right dose. About 52 participants …

This study tests whether giving palifermin and leuprolide acetate (or degarelix) can help the immune system recover more quickly after a stem cell transplant from a donor. The trial includes 82 adults with blood cancers like leukemia or lymphoma. Researchers will measure CD4+ T c…

This study tests a daily pill called PCI-32765 for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are over 65 or have a specific genetic change (17p deletion). These groups often don't respond well to standard chemotherapy. The goal is to s…

This early-stage study tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Doctors take a patient's own T cells (a type of immune cell), add a gene that helps them recognize and attack leukemia…

This study tests the safety of a drug called neratinib in children and teens whose solid tumors, brain tumors, lymphoma, or leukemia have returned or not responded to standard treatments. Researchers are looking for the best dose and watching for side effects. The goal is to see …

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia (CLL) in 120 adults. Lenalidomide boosts the immune system and blocks tumor blood vessel growth, while rituximab targets and kills cancer cells. The goal is to shrink or st…

This study was designed to test the safety of a new drug called MT-0169 in people with acute leukemia (AML or T-ALL) that has come back or not gone away with standard treatment. The drug targets a protein called CD38 found on leukemia cells. However, the trial was withdrawn befor…

This study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus a chemotherapy drug (azacitidine) in people with myelodysplastic syndromes (MDS), a bone marrow disorder that can lead to leukemia. About 99 adults with MDS, either untreated or who have fai…

This study tests whether adding the targeted drug ibrutinib to standard chemotherapy can completely clear chronic lymphocytic leukemia (CLL) from the bone marrow in younger, untreated patients. About 85 participants will receive the combination and be monitored for two years afte…

This early-phase study tests whether the drug talazoparib can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have a specific mutation in the cohesin complex. The study includes 13 participants who cannot receive standard intensive chemotherapy…

This early-phase study tests a personalized cell therapy for children and young adults with a type of leukemia that has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize two markers (CD19 and CD22) on leukemi…

This study tests whether the drug ruxolitinib can help people with chronic myelomonocytic leukemia (CMML), a rare blood cancer. About 29 adults will receive the drug to see if it improves blood counts, shrinks the cancer, or keeps it stable. The goal is to control the disease and…

This study tests an experimental drug called BGB-11417 in 100 adults whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to other treatments. The goal is to see if the drug can shrink or eliminate cancer cells. Particip…

This study tests whether a probiotic called Lactobacillus plantarum can prevent a serious gut condition called graft-versus-host disease (GvHD) in children receiving a donor stem cell transplant. About 173 children with blood cancers or other blood disorders are taking part. The …

This study looks at whether adding methadone to the usual pain medicine (morphine) can better control severe mouth pain in children aged 6 to 18 getting a stem cell transplant. The mouth pain, called mucositis, is a common side effect of the chemotherapy given before transplant. …

This study looks at whether a special fencing program can help adults with leukemia or lymphoma stay physically active while receiving strong treatments in the hospital. The program is designed to be done in bed, in a chair, or standing up, and aims to reduce muscle weakness and …

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancer. Parents provide details abou…

This study collects white blood cells from people with leukemia or lymphoma whose cancer has not been cured by standard treatments. The cells are stored and may later be used to create a personalized therapy called CAR T-cells. The goal is to make it easier for patients to get th…

This study is testing a new system that combines aging, mental health, and social needs checks for cancer patients aged 65 and older. The goal is to help doctors provide care that fits each patient's life. About 35 people with different cancers will try it during their first visi…

This study was designed to track immune system recovery and test a pneumococcal vaccine (PCV-21) in people receiving CAR-T therapy for blood cancers or solid tumors. Participants would have had regular clinic visits and blood tests for up to 24 months. However, the study was with…

This study follows up to 5,000 children and teens who have had cancer or a stem cell transplant. Researchers collect health information over many years to learn about long-term side effects of treatment. The goal is to reduce future health problems and improve quality of life for…

This study follows over 64,000 adults who grew up on farms to see if early-life exposures to pesticides and other agricultural factors are linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track cancer and other d…

This study collects blood and tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to find genes and proteins linked to cancer. The goal is to better understand why some patients develop complications or have differ…

This study collects blood or saliva samples from people with cancer and their relatives to build a DNA bank. Researchers will use these samples to study how genes may increase the risk of developing certain cancers. About 992 participants are expected. No treatment or direct bene…

This study looks at whether a daily mindfulness app can help adult survivors of childhood leukemia or lymphoma cope with stress. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs. The goal is to see if this approach is practical and …