AORTIC VALVE STENOSIS

This study compares two types of replacement heart valves (Allegra and Sapien) in 104 people whose surgically implanted aortic valve has stopped working properly. The goal is to see which valve does a better job at improving blood flow through the heart. Participants will be rand…

This study looks at a newer version of a heart valve used to replace a narrowed aortic valve. The valve has special technology to prevent calcium buildup and is stored dry to keep it in better condition. Researchers will follow 150 people who get this valve to see how well it wor…

This study tests a new balloon-expandable heart valve (SAPIEN X4) in 200 people whose surgically replaced aortic valve is failing. Participants must be at high or greater risk for another open-heart surgery. The goal is to see if the new valve is safe and effective at controlling…

This study tests whether a daily pill called enavogliflozin (a type of SGLT2 inhibitor) can reduce the risk of major heart problems or worsening heart failure in people who have already had a valve replacement for severe aortic stenosis and also have heart failure with preserved …

This study is testing a new heart valve device (VitaFlow Liberty) in 122 people with severe aortic stenosis who are too high-risk for open-heart surgery. The valve is placed using a thin tube through a blood vessel, avoiding major surgery. Researchers will track how many patients…

This study is testing a new heart valve called Hydra for people with severe aortic stenosis, a condition where the heart's main valve is narrowed. About 50 participants will get the valve and be followed for a year to see if it works well and is safe. The study also looks at how …

This study is testing a new heart valve called Hydra for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. Researchers will check how safe and effective the valve is up to one year after it's implanted. About 250 adults who are already e…

This study tests whether a quick blood test can detect leaks around a new heart valve during a minimally invasive procedure. About 944 people with severe aortic stenosis will participate. The goal is to improve outcomes by catching leaks early without needing general anesthesia o…

This study compares two approaches for people aged 65+ with moderate aortic stenosis (a narrowed heart valve). One group gets a less invasive valve replacement (TAVR), the other gets regular monitoring. The goal is to see if early treatment reduces death and heart failure. The st…

This study compares a newer, gentler heart-lung machine (MiECC) to the standard machine used during heart surgery. The goal is to see if the newer machine reduces serious complications like heart attack, stroke, or kidney injury. About 1,300 adults having planned coronary bypass …

This study tests whether using remote monitoring devices at home can allow people to safely leave the hospital the same day they receive a new heart valve (TAVI). About 216 participants will be randomly assigned to either standard care or a home monitoring program that tracks hea…

This study looks at people whose TAVI heart valve has stopped working well and may need a second TAVI procedure (Redo TAVI). Researchers will track 550 patients to see how safe and effective this second procedure is, and compare it to open-heart surgery or medication. The goal is…

This study is looking at how well a new device called the Hydra TAVI system works for people with severe aortic stenosis, a condition where the heart's aortic valve is narrowed. Researchers will track 500 patients who get the implant to see how safe it is and how it affects their…

This study is testing a new device called GEMINUS to replace a narrowed heart valve in people with severe aortic stenosis. The goal is to see if the procedure is safe and works as intended. About 30 participants will be followed for up to 5 years after the procedure.

This study is a registry that will follow 150 people with severe aortic stenosis who receive a new type of heart valve (Myval) through a minimally invasive procedure called TAVI. The goal is to track how safe and effective the valve is by monitoring complications like death, stro…

This study compares giving a drug called protamine to all patients after a minimally invasive heart valve replacement (TAVI) versus giving it only when needed. The goal is to see if routine use lowers the chance of death or serious bleeding within 30 days. About 1000 adults with …

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This study looks at how different sedation medicines affect recovery after a heart valve procedure called TAVR. About 126 people having TAVR will be randomly assigned to one of three common sedatives. They will fill out short surveys about pain and well-being on days 1 and 7 afte…

This study tests whether giving iron through a vein can improve quality of life and exercise ability in older adults with a narrowed heart valve and low iron levels after a minimally invasive valve replacement. About 400 participants will be randomly assigned to receive either ir…

This study tests a shockwave technique (intravascular lithotripsy) to break up heavy calcium buildup in the iliac arteries of 50 people with severe aortic stenosis. The goal is to make room for a new heart valve to be delivered through a leg artery, avoiding more invasive approac…

This study compares two types of nerve blocks (PENG block and fascia iliaca block) to standard local anesthesia for pain control during a minimally invasive heart valve replacement called TAVI. Researchers will measure how much sedation patients need during the procedure and thei…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in people with aortic stenosis. Researchers will use exercise MRI to see which valve performs better during physical activity. About 90 adults who need a valve replacement will parti…

This study tests a new device called HemoCept that measures blood volume and heart efficiency during a heart valve replacement procedure (TAVR). Researchers want to see if the device can detect changes in blood flow as accurately as standard tests. About 20 adults with aortic val…

This study will follow 2500 people who had a TAVR procedure (a less invasive way to replace a heart valve) to understand their risks of bleeding or blood clots afterward. Researchers will track different blood thinner treatments and valve types to see how they affect these risks …

This study looks at whether CT and heart echo scans taken before and after a TAVI procedure can help predict how the new heart valve will perform over time. Researchers will collect scan data from 40 adults with severe aortic stenosis and use it to train a computer program. The g…

This study looks at 310 people who need a second heart valve placed inside an older one. Doctors want to see if using ultrasound or a pressure catheter gives better information about how well the new valve works. The goal is to improve quality of life and reduce complications.

This study looks at a new way to place a heart valve (Navitor) during a procedure called TAVR. Normally, doctors try to align the valve carefully, but this can make it harder to reach the heart arteries later if needed. The study will test if randomly placing the valve makes it e…

This study watches 150 adults getting heart valve procedures (TAVI or M-TEER) to see if their sleep breathing improves. Participants take a sleep test before and 6 months after the procedure. The goal is to learn how fixing heart valves might help sleep problems like apnea.

This study aims to improve how doctors analyze heart function using advanced MRI scans. Researchers will develop computer models to automatically measure heart chamber performance in 190 adults with severe aortic stenosis who are scheduled for valve replacement. The goal is to ma…

This study looks at why some replacement heart valves (TAVI) may wear out faster than others. Researchers will use a special PET scan to detect tiny calcium deposits, an early sign of valve damage, in 180 people who had a TAVI about 5 years ago. They will compare those with and w…

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how heart disease develops, not to provide treatme…

This study is following 10,000 adults with heart valve disease to learn how the condition changes over time. Researchers will use scans and tests to track disease progression and see how treatments like surgery, medications, or lifestyle changes may affect outcomes. The goal is t…

This study looks at whether a structured conversation between doctors and patients helps people with severe aortic stenosis make a better choice between two heart valve treatments: TAVR (a less invasive procedure) or SAVR (open-heart surgery). About 140 patients aged 70 and older…