Aortic valve stenosis
Clinical trials for Aortic valve stenosis explained in plain language.
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Can a less invasive valve replacement tame a failing aortic valve?
Disease control Stopped earlyThis study is a patient registry that collects information on people with severe aortic stenosis or aortic regurgitation who are treated with the Trilogy heart valve system, a device implanted via a catheter (TAVI) to replace the aortic valve without open-heart surgery. The goal …
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: JenaValve Technology, Inc. • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Heart valve study halted early: which blood thinner is safer?
Disease control Stopped earlyThis study compared two antiplatelet drug regimens after transcatheter aortic valve implantation (TAVI) for aortic stenosis. One group received ticagrelor alone, the other received aspirin plus clopidogrel. The goal was to see which caused fewer serious complications like bleedin…
Matched conditions: AORTIC VALVE STENOSIS
Phase 3 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Experimental heart slicing procedure tested on one patient
Disease control Stopped earlyThis early study tested a new procedure called SESAME that uses a wire threaded through blood vessels to slice away excess heart muscle in people with hypertrophic cardiomyopathy. Only one adult participated before the study was terminated. The goal was to see if the technique co…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Heart valve scoring device trial halted after just one patient
Disease control Stopped earlyThis study tested a device called Leaflex™ Performer, which is threaded through a blood vessel to the heart to score and loosen calcium buildup on stiff aortic valves. It was designed for people with severe aortic stenosis who cannot have standard valve surgery or replacement. Ho…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: Pi-cardia • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Massive german study compares new and old heart valve procedures
Knowledge-focused Stopped earlyThis study was a large registry that planned to follow 180,000 patients in Germany with aortic valve problems (leaky or narrowed valves). The goal was to compare newer, less invasive treatments like TAVI with standard open-heart surgery to see which works best and for whom. Resea…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: German Aortic Valve Registry • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC