AORTIC VALVE STENOSIS

This study compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. About 1,960 participants will be randomly assigned to receive either a balloon-expandable or a self-expanding valve. The goal is to see if one design…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in people with a small aortic valve opening and severe narrowing. About 1,100 participants will be followed to see which valve performs better in terms of survival, stroke, heart fai…

This study tests a new device called the Navitor TAVI system, which replaces a narrowed heart valve without open-heart surgery. It includes up to 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Researchers use MRI scans to find early heart muscle scarring, which can signal future trouble. Participants with scarring are randomly assigned to either standard care or…

This study planned to test a device called Leaflex Performer for people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrow. The goal was to see if the device is safe and works well. However, the study was withdrawn before any participants were …

This study tests whether icosapent ethyl, a purified fish-oil medication, can slow calcium buildup in the aortic valve of 110 adults aged 50+ with mild-to-moderate aortic valve stenosis. Participants receive the drug or a placebo, and researchers measure changes in valve calcium …

This study compares two ways to replace a narrowed heart valve: a less invasive procedure (TAVI) versus open-heart surgery (SAVR). About 1,400 people with severe aortic stenosis and intermediate surgical risk are being followed for up to 5 years. The main goal is to see if TAVI i…

This study tests two newer self-expanding heart valves and a less invasive approach for replacing a narrowed aortic valve. About 836 people with severe aortic stenosis will be randomly assigned to receive one of the new valves or standard care, and also to a minimalist procedure …

This study tests a less invasive procedure called TAVR against traditional open-heart surgery for people with severe aortic stenosis who are at low risk for surgery. About 2,200 participants will be followed for two years to see if TAVR is as safe and effective as surgery in prev…

This study tests whether colchicine, an anti-inflammatory medicine, can slow the worsening of aortic valve stenosis—a common heart valve condition. About 150 adults with moderate, symptom-free valve narrowing will take colchicine or a placebo for up to 2 years. The goal is to see…

This study looks at how well the SAPIEN 3 Ultra heart valve works in 200 people with severe, symptomatic aortic stenosis who are at intermediate or higher risk for open-heart surgery. Researchers are checking if the valve works as intended and tracking safety issues like stroke, …

This study tests a new heart valve device (CENTERA THV) in 101 people with severe aortic stenosis who are at intermediate risk for surgery. The valve is placed without open-heart surgery. The main goal is to see if it is safe and works well. This is not a cure, but aims to contro…

This study compares two types of replacement heart valves placed through a thin tube (TAVI) in people whose surgically implanted aortic valves are small (23mm or less) and no longer working well. The goal is to see which device leads to fewer problems like high pressure across th…

This study tests whether a smartphone app can detect severe aortic stenosis, a common but serious heart valve condition, by recording heart sounds with the phone's built-in microphone and analyzing them with machine learning. Researchers will enroll 100 adults with either no valv…

This study looks at whether it is safe for people with narrowed heart valves to leave the hospital just 24 hours after a minimally invasive valve replacement (TAVI). Researchers will track 585 patients for serious problems like stroke, heart attack, or need for a pacemaker. The g…

This study was designed to measure a protein called SGLT2 in heart muscle samples from people with aortic valve stenosis, both with and without heart failure. The goal was to understand why a class of diabetes drugs called gliflozins may benefit heart failure patients. However, t…

This study follows 900 people with a narrowed heart valve (aortic stenosis) who had either open-heart surgery or a less invasive procedure to replace the valve. Researchers are tracking deaths, heart attacks, and strokes to see which approach works better over time. The goal is t…

This study watches 1000 patients with severe aortic stenosis to see how their heart rhythms change after a TAVR valve procedure. Researchers track abnormal beats and other rhythm issues over a year using heart monitors. The goal is to learn what affects recovery and help doctors …

This study tests whether wearing a continuous heart monitor for at least a week before a TAVI procedure can detect hidden irregular heartbeats in people with severe aortic stenosis. About 106 participants will use the monitor to find these silent arrhythmias, which may lead to tr…

This study looks at why aortic stenosis (a narrowing of the heart's aortic valve) gets worse over time. Researchers will check blood markers and special ultrasound patterns in 65 people with mild or moderate valve disease. The goal is to find new ways to slow the disease down, no…

This study followed 900 adults who had aortic valve replacement to see how safe and effective the procedure is in routine hospital care. Researchers tracked deaths from any cause and heart-related deaths. The goal is to understand real-world results beyond controlled clinical tri…

This study looks at 364 people with mild to moderate aortic valve stenosis (a narrowing of the heart's main valve). Researchers compare those with high levels of lipoprotein(a) (a type of fat in the blood) to those with low levels, to see if the valve disease gets worse faster. T…