AORTIC VALVE STENOSIS

This study is observing how well and how safely aortic valve replacement surgery works for patients in everyday hospital settings. It is following 900 adults who have had the surgery to track their health outcomes, including survival rates and complications, for up to five years.…

This study is testing whether patients can safely leave the hospital just 24 hours after having a TAVI procedure to replace a narrowed aortic valve. Researchers are following 585 patients who receive this minimally invasive heart valve replacement to see if early discharge leads …

This study compares two different types of replacement heart valves for patients whose previous surgical valve has failed and is small in size. Researchers want to see which valve performs better at reducing pressure differences across the valve and preventing valve-patient size …

This early study aimed to test the safety and performance of the Leaflex Performer device in people with severe aortic valve narrowing who had symptoms but were not immediate candidates for valve replacement surgery. The trial planned to follow participants for one year after the…

This study tested a less invasive procedure called TAVR against traditional open-heart surgery for replacing a severely narrowed aortic valve. It involved over 2,200 patients who were considered at low risk for complications from surgery. The main goal was to see if the TAVR proc…

This study is testing whether a medication called icosapent ethyl can slow the progression of aortic valve stenosis, a condition where the heart's main valve narrows. It will involve about 110 adults over 50 with mild to moderate disease. The main goal is to see if the treatment …

This trial is comparing two different types of replacement heart valves for people with a severely narrowed aortic valve and a small aortic root. Over 1,100 participants were randomly assigned to receive either a self-expanding valve or a balloon-expandable valve. The main goal i…

This study is testing a new device called the Navitor valve, which is designed to replace a narrowed aortic heart valve without major open-heart surgery. It will enroll about 1,500 people with severe, symptomatic aortic stenosis who are considered at low or intermediate risk for …

This study is testing whether colchicine, an anti-inflammatory medication, can slow the progression of aortic valve stenosis—a serious heart condition where the main heart valve narrows. Researchers are enrolling 150 patients with moderate but symptom-free valve narrowing to see …

This study is testing if performing heart valve replacement surgery earlier than current guidelines recommend can improve outcomes for patients with severe aortic stenosis. It focuses on patients who have no symptoms but show early signs of heart muscle scarring on an MRI scan. T…

This study aims to see if two newer types of self-expanding heart valves work as well as each other, and if a simpler, 'minimalist' procedure is as safe and effective as the standard approach. It involves 836 adults with severe, symptomatic aortic valve stenosis who need a valve …

This study is testing whether a medication called empagliflozin helps the heart recover better after surgery to replace a narrowed aortic valve. About 205 patients who have this surgery will receive either the real drug or a placebo pill for six months. Researchers will check if …

This study aims to find out which of two common types of heart valve implants is better for people with severe, symptomatic aortic stenosis. It will compare a balloon-expandable valve to a self-expanding valve in nearly 2,000 patients. The main goal is to see which valve leads to…

This study is testing the safety and performance of a new, less invasive heart valve replacement system. It is for people with severe, symptomatic aortic stenosis who are at intermediate risk for traditional open-heart surgery. The goal is to see if this new device can effectivel…

This study is testing a smartphone app that uses the phone's microphone and artificial intelligence (AI) to listen for signs of aortic stenosis, a narrowing of a major heart valve. The goal is to see if this app can be a faster, more accessible screening tool compared to the curr…

This study tests whether wearing a heart monitor for one week before a minimally invasive aortic valve replacement helps doctors spot hidden heart rhythm problems. Researchers want to see if finding these rhythm issues early allows for better treatment planning before the procedu…

This study aims to understand how heart rhythms change after a minimally invasive procedure to replace a narrowed heart valve. Researchers are looking back at data from 1,000 patients who had the procedure to track irregular heartbeats over time. The goal is to identify which pat…

This study is a registry that collects information on patients who have had aortic valve replacement surgery. It aims to compare the long-term effectiveness and safety of two different valve replacement procedures: traditional open-heart surgery and a less invasive catheter-based…

This study was withdrawn before any participants were enrolled. It planned to examine a specific protein (SGLT2) in heart tissue samples from patients undergoing surgery for a narrowed heart valve. The goal was to compare protein levels in patients with and without heart failure …

This study aims to understand if high levels of a specific blood fat called lipoprotein(a) cause a narrowed heart valve (aortic stenosis) to worsen faster. Researchers are comparing the progression of the valve disease over time in 364 patients who have either high or low levels …