Can a second keyhole valve fix a failing first one? new study aims to find out

NCT ID NCT06557798

Recruiting now Disease control Sponsor: The Leeds Teaching Hospitals NHS Trust Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 31 times

Summary

This study looks at people whose TAVI heart valve has stopped working well and may need a second TAVI procedure (Redo TAVI). Researchers will track 550 patients to see how safe and effective this second procedure is, and compare it to open-heart surgery or medication. The goal is to give doctors clear guidance on the best treatment for failed TAVI valves.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ASST Spedali Civili Di Brescia
RECRUITING

Brescia, Italy
Aalborg Universitethospital
RECRUITING

Aalborg, Denmark
Amphia Hospital
RECRUITING

Breda, Netherlands
Asklepios Klinik St. Georg
RECRUITING

Hamburg, Germany
Azienda Ospedaliera Ordine Mauriziano di Torino
RECRUITING

Torino, Italy
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele
RECRUITING

Catania, Italy
Brest University Hospital Centre
RECRUITING

Brest, France
Bristol Royal Infirmary
RECRUITING

Bristol, United Kingdom
CHRU Hospitals of Tours
RECRUITING

Tours, France
Centre Hospitalier Universitaire de Montpellier
RECRUITING

Montpellier, France
Centro Cardiologico Monzino
RECRUITING

Milan, Italy
Clinical Saint Augustin - Elsan
RECRUITING

Bordeaux, France
Clinique Pasteur Toulouse
RECRUITING

Toulouse, France
Deutsches Herzzentrum Berlin
WITHDRAWN

Berlin, Germany
Edith Wolfson Medical Center
RECRUITING

Holon, Israel
Erasmus University Medical Center
RECRUITING

Rotterdam, Netherlands
Fondazione Poliambulanza Istituto Ospedaliero
RECRUITING

Brescia, Italy
Freeman Hospital
RECRUITING

Newcastle upon Tyne, United Kingdom
Glenfield Hospital
RECRUITING

Leicester, United Kingdom
Golden Jubilee National Hospital
RECRUITING

Glasgow, United Kingdom
Guys and St Thomas' NHS Foundation Trust
RECRUITING

London, United Kingdom
HELIOS Herzzentrum Leipzig GmbH
RECRUITING

Leipzig, Germany
HUS Helsinki University Hospital
RECRUITING

Helsinki, Finland
Haukeland Sykehus
RECRUITING

Bergen, Norway
Henri Mondor University Hospital
RECRUITING

Créteil, France
Herz- und Diabeteszentrum NRW
RECRUITING

Bad Oeynhausen, Germany
Herzzentrum Dresden Universitätsklinik
RECRUITING

Dresden, Germany
Hospital Marie Lannelongue
RECRUITING

Paris, France
Humanitas Research Hospital - RCCS Istituto Clinico Humanitas di Milano
WITHDRAWN

Milan, Italy
ICPS Hôpital privé Jacques-Cartier
RECRUITING

Massy, France
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Italy
IRCSS Policlinico San Donato
RECRUITING

San Donato Milanese, Italy
Inselspital - Universitätsspital Bern
RECRUITING

Bern, Switzerland
Institute Mutualiste Montsouris
RECRUITING

Paris, France
Kerckhoff Klinik
RECRUITING

Bad Nauheim, Germany
Klinikum Dortmund GmbH - St. Johannes Hospital
RECRUITING

Dortmund, Germany
LMU Klinikum
RECRUITING

München, Germany
Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, LS1 3EX, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
Les Hospital Universitaires de Strasbourg
RECRUITING

Strasbourg, France
Luzerner Kantonsspital
RECRUITING

Lucerne, Switzerland
Maastricht University Medical Center (MUMC)
RECRUITING

Maastricht, Netherlands
Manchester Royal Infirmary
RECRUITING

Manchester, United Kingdom
Medipole Lyon-Villeurbanne
RECRUITING

Villeurbanne, France
New Cross Hospital
RECRUITING

Wolverhampton, United Kingdom
Nya Karolinska Sjukhuset Solna
RECRUITING

Solna, Sweden
Oslo University Hospital
RECRUITING

Oslo, Norway
Ospedale Borgo Trento - Azienda Ospedaliera Universitaria Integrata Verona
RECRUITING

Verona, Italy
Ospedale San Martino - IRCCS Ospedale Policlinico
RECRUITING

Genova, Italy
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, OX3 9DU, United Kingdom
Queen Elizabeth Hospital
RECRUITING

Birmingham, United Kingdom
Rabin Medical Center - Belinson Campus
RECRUITING

Petah Tikva, Israel
Radboud Universitair Medisch Centrum
WITHDRAWN

Nijmegen, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, Denmark
Royal Sussex County Hospital
RECRUITING

Brighton, BN2 1ES, United Kingdom
Sahlgrenska University Hospital
RECRUITING

Gothenburg, Sweden
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Israel
Skånes Universitetssjukhus Lund
RECRUITING

Lund, Sweden
St. George's Hospital
RECRUITING

London, United Kingdom
Turku University Hospital
RECRUITING

Turku, Finland
Universitatsklinikum Dusseldorf (University Hospital Dusseldorf)
RECRUITING

Düsseldorf, Germany
Universitatsklinikum Frankfurt
RECRUITING

Frankfurt, Germany
Universitatsklinikum Koln (AoR)
RECRUITING

Cologne, Germany
Universitatsklinikum Ulm (University Hospital Ulm)
RECRUITING

Ulm, Germany
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
University Hospital of Nimes
RECRUITING

Nîmes, France
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
Universitätsklinikum Schleswig-Holstein (UKSH)
RECRUITING

Kiel, Germany
Universitätsklinikum Schleswig-Holstein (UKSH)
RECRUITING

Lübeck, Germany
Århus Universitetshospital
RECRUITING

Aarhus, Denmark

Conditions

Explore the condition pages connected to this study.

AORTIC VALVE STENOSIS