Heart valve study tests safer bleeding control after TAVI

NCT ID NCT05774691

Completed Disease control Sponsor: St. Antonius Hospital Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 40 times

Summary

This study looked at whether giving a drug called protamine to all patients after a minimally invasive heart valve replacement (TAVI) reduces bleeding complications compared to giving it only when needed. The trial involved 1000 adults with aortic valve stenosis. The goal was to see if routine protamine use lowers the risk of death or serious bleeding within 30 days after the procedure.

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Contacts and locations

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Locations

A.S.Z. Aalst

Aalst, Belgium
Amsterdam University Medical Center

Amsterdam, Netherlands
Leiden University Medical Center

Leiden, South Holland, Netherlands
Maastricht UMC

Maastricht, Limburg, Netherlands
St. Antonius Hospital

Nieuwegein, Utrecht, Netherlands
University Hospitals Leuven

Leuven, Belgium

Conditions

The condition(s) this trial relates to.

allergic disease aortic valve stenosis Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS