ALCOHOL USE DISORDER

This study tests a stepped alcohol treatment program delivered via telemedicine for 180 adults with chronic liver disease and unhealthy alcohol use. Participants are randomly assigned to either the treatment program (motivational interviewing plus possible addiction medicine refe…

This study looks at whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment and drink less. About 1800 adults in Denmark will take part. The goal is to see if this blended approach works better than standard in-person trea…

This study tests a telehealth program called Ria for people with alcohol use disorder. Participants get medication, coaching, and a Bluetooth breathalyzer through their phone. The goal is to see if this approach helps reduce heavy drinking more than just waiting for treatment.

This study tests whether a medication already approved for other uses can help people with HIV reduce their alcohol use. Researchers will work with 30 participants to see if the approach is practical, safe, and acceptable. The goal is to improve health outcomes by combining the m…

This study tests whether a personalized program—including patient outreach, health education, and financial help—can lower the risk of dying from preventable causes like heart disease, heavy drinking, and HIV. About 87 low-income adults aged 35 to 64 are taking part. The program …

This study tests whether online mindfulness classes help people with alcohol use disorder stay in recovery longer than online support groups. About 470 adults who recently tried to cut back or stop drinking will take part. The goal is to see if mindfulness helps people avoid heav…

This study looks at whether offering small cash rewards can help people who have had a liver transplant due to alcohol-related liver disease stay away from alcohol. Thirty adults who have returned to drinking after their transplant will either receive standard care or a 10-week p…

This study tests a special counseling program (CAMI) designed for Latinx adults who drink heavily and may also use drugs. The program includes discussions about immigration-related stress. Researchers want to see if CAMI reduces heavy drinking days, drug use, and emotional distre…

This study tests whether mazdutide, a drug originally developed for other conditions, can help people with alcohol use disorder drink less. About 300 adults with current alcohol use disorder will receive either mazdutide or a placebo for several weeks. Researchers will track chan…

This pilot study tests whether psilocybin or ketamine, combined with talk therapy, can help men aged 25-65 with moderate to severe alcohol use disorder reduce their drinking. Twenty participants will receive one of the two treatments, and researchers will track their alcohol use …

This study tests a program for couples to help adolescent girls and young women (ages 15-24) living with HIV in Uganda stay engaged in their HIV care. The program works by reducing male partner alcohol use and the risk of intimate partner violence. About 80 participants will join…

This study tests new technology-driven programs to help people manage their alcohol use and well-being. The programs focus on setting goals and learning skills to improve health. Researchers want to see if these virtual strategies help more people start and stick with treatment a…

This study looks at whether offering alcohol treatment in Black churches helps more people start and stick with treatment compared to traditional clinics. About 137 Black adults with alcohol use disorder will receive therapy either in a church or a clinic. The goal is to see whic…

This small early-phase study tests whether the drug apremilast can help people with alcohol use disorder drink less. Ten adults who drink heavily will take the medication and then have their alcohol intake measured in a controlled setting. The goal is to see if apremilast reduces…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This study tests whether giving small monetary rewards for sober breathalyzer readings, collected remotely via a smartphone app, helps people with alcohol use disorder stay abstinent after detox. About 91 participants who recently completed detox will be monitored for several mon…

This study tests whether a smartphone app and breathalyzer can help people with alcohol use disorder stay sober by rewarding them with money for each day they don't drink. About 211 adults who want to quit drinking will use the app and breathalyzer at home. The goal is to make a …

This study tests a new type of brain stimulation, called deep rTMS, to help people with alcohol use disorder. The treatment targets brain areas involved in memory and decision-making. Researchers will measure if it reduces alcohol cravings and actual drinking in 44 participants.

This study looks at whether using existing medications in a new way can help people with HIV who also have alcohol use disorder drink less. About 30 participants will receive the medication along with counseling and check-ins from a pharmacist. The goal is to see if this approach…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part in either an emotion regulation workshop or a standard education session during their aca…

This study aims to develop and test a therapy for alcohol use disorder that is adapted for transgender and gender non-conforming adults. About 30 participants will try a version of interpersonal psychotherapy tailored to their unique life experiences. The goal is to see if the th…

This study tests whether a special ketone supplement (Kenetik) can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink for 5 days. Researchers will measure how much standard wi…

This study looks at whether adding oxytocin (a natural hormone) to talk therapy helps veterans with both PTSD and alcohol use disorder. About 175 veterans will receive either oxytocin or a placebo along with therapy. The goal is to see if oxytocin reduces drinking and PTSD sympto…

This study tests whether citicoline, a common supplement, can reduce inflammation in the brain and improve thinking skills in 56 teens and young adults (ages 16-22) who drink alcohol. Participants take either citicoline or a placebo pill for a period, and researchers measure immu…

This study tests a special therapy group designed for women veterans who struggle with alcohol use. The therapy, called cognitive behavioral therapy (CBT), helps women understand and change their drinking habits. About 162 women will take part, and researchers will check if this …

This pilot study tests whether a non-invasive brain stimulation technique called rTMS can help reduce alcohol cravings in veterans who also have mild traumatic brain injury (mTBI) and/or post-traumatic stress disorder (PTSD). The study plans to enroll 20 veterans, with half recei…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can reduce heavy drinking and improve thinking skills in older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Researchers will measure changes in dri…

This study tests whether a 6-session phone therapy program (Acceptance and Commitment Therapy) can help young adults aged 18-25 in Hong Kong who drink heavily. 60 participants will either get the therapy or supportive calls. Researchers will check if the program is practical and …

This study tests whether taking a probiotic supplement for four weeks can reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither they n…

This study tests a smartphone-based program called LDART that provides social support to help adults with alcohol use disorder cut down on drinking. About 80 participants in Connecticut will use the app for 28 days and report their drinking habits. The goal is to see if the progr…

This study looks at different methods to help primary care clinics screen adults for substance use problems. It involves 144 clinic staff from 48 practices. Researchers compare coaching, team learning, and financial rewards to see which works best.

This early-stage study looks at how a single dose of diclofenac, a common painkiller, affects a brain chemical called kynurenic acid in 12 adults with alcohol use disorder. The goal is to see if diclofenac can block a specific enzyme, which might help reduce alcohol cravings. Thi…

This study looks at how alcohol use disorder and mild traumatic brain injury together affect the brain in veterans. The goal is to find the best brain area to stimulate with a non-invasive technique called rTMS to help improve daily function. About 100 veterans will take part to …

This study looks back at 10,000 hospital patients to understand how often low sodium levels (hyponatremia) occur and how they are treated. Researchers want to see how fast sodium is corrected and if that affects serious brain complications. The goal is to learn from past cases to…

This study looks at how alcohol changes the way our brains work together during social situations. Researchers will monitor brain activity in pairs of people while they drink and interact. The goal is to understand the brain mechanisms behind alcohol's social effects. 240 regular…

This study aims to better understand how the brain works in people with alcohol use disorder. Researchers are testing a new assessment tool that uses surveys and computer tasks to measure thinking, emotions, and decision-making. Up to 1,400 adults will participate, and the goal i…

This study follows 250 people with Alcohol Use Disorder as they go through 12 weeks of therapy and one year of follow-up. Researchers want to learn how recovery happens, what helps people stay sober, and how to tell the difference between a temporary improvement and lasting recov…

This small study looks at whether thinking about future events (Episodic Future Thinking) and low-intensity focused ultrasound can change how people with chronic pain and alcohol use disorder experience pain and cravings. Ten adults will complete tasks and rate their pain and alc…

This early-stage study tests whether a drug called brexanolone is safe and practical for people who have both posttraumatic stress disorder (PTSD) and alcohol use disorder. Researchers will give the drug to 25 adults aged 21-55 and watch for side effects. The goal is to gather in…

This study follows 20 adults in Oregon who are already receiving psilocybin services for alcohol use disorder. Researchers only observe and collect data—they do not provide treatment. The goal is to see if psilocybin-assisted care reduces heavy drinking days over time.

This study looks at how alcohol affects sleep in healthy men and women aged 21-45, focusing on the role of sex hormones. Researchers will compare sleep patterns after alcohol or a placebo, especially during different phases of women's menstrual cycles. The goal is to understand w…

This study follows 733 adults with alcohol use disorder to learn what helps people recover and what leads to relapse. Researchers measure thinking, social life, and drinking patterns over time. The goal is to find new ways to prevent relapse and support long-term recovery.

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. The researchers will compare a team-based problem-solving approach (Participatory S…

This study uses a special PET/CT scan to measure inflammation in the brain and body of people with alcohol use disorder (AUD) compared to healthy volunteers. Up to 90 participants (60 with AUD, 30 healthy) will receive one scan with an investigational tracer. The goal is to under…