ALCOHOL USE DISORDER

This study tests a new, non-invasive brain stimulation technique called tTIS to see if it can reduce cravings for alcohol. Researchers will target the amygdala, a brain area linked to emotion and addiction. Sixty adults with alcohol use disorder will participate, and the study wi…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease stop drinking alcohol. About 64 participants will receive either semaglutide or a placebo, plus counseling, for 16 weeks. The main goal is to…

This small pilot study will test whether nimodipine, a drug typically used for blood pressure, can reduce alcohol drinking in 5 adults with Alcohol Use Disorder. Participants will stay overnight at a hospital, receive nimodipine, and then have the option to drink alcohol or recei…

This study tests whether peer support specialists can help liver transplant recipients with a history of alcohol-related disease stay sober and keep up with medical care. About 95 participants who have been alcohol-free for 1-3 years will be assigned to work with a peer supporter…

This study tests whether daridorexant, a medication that blocks certain brain signals related to wakefulness, can reduce alcohol cravings and improve sleep in people with alcohol use disorder and sleep problems. About 150 adults with moderate to severe alcohol use disorder and po…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days can help people going through alcohol withdrawal. The goal is to reduce gut leaks and improve symptoms like cravings and anxiety. About 138 adults hospitalized for detox will take part.

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help veterans with alcohol use disorder drink less. About 622 veterans will receive either the drug or a placebo injection for 28 weeks. The main goal is to see if it lowers their drinking risk le…

This study tests whether offering financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. Participants are randomly assigned to receive either escalating rewards fo…

This study tests a coordinated care program for men with alcohol problems in primary care clinics in Goa, India. About 1,022 men will receive either the program or usual care. The program uses mobile messages, counseling, or home detox and therapy, depending on drinking severity,…

This study looks at whether intensive counseling, with or without a medication called cytisine, can help people with HIV quit smoking and cut down on heavy drinking. The trial will enroll 300 adults in Nairobi, Kenya, who smoke and drink heavily. The goal is to find better ways t…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder drink less. Thirty-six adults who recently completed detox will receive either a full or low dose of psilocybin during two th…

This study tests whether a single dose of a nutritional ketone supplement (Kenetik) can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplem…

This study tests whether a smartphone app that uses machine learning can send personalized messages to help people with alcohol use disorder reduce heavy drinking and avoid relapse. About 416 adults who have recently stopped drinking will use the app and complete surveys over fou…

This study tests whether adding a cognitive training program to standard addiction treatment can improve overall self-confidence in people recovering from alcohol use disorder. About 130 adults who have been sober for 1 to 4 weeks will be randomly assigned to receive either the e…

This pilot study tests whether Emotional Brain Training (EBT), a method that teaches skills to shift mood from negative to positive, can help manage stress, anxiety, and cravings in adults being treated for substance use disorders. About 54 participants will either receive standa…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in 60 adults with opioid and alcohol use disorder. Participants will receive TMS alongside their usual treatment program. The goal is to see if TMS reduces cravings, withdrawal sym…

This study tests whether combining semaglutide (a diabetes drug) with naltrexone (an addiction medication) is safe and helps reduce drinking in people with alcohol use disorder. About 45 adults enrolled in a 4-week inpatient program will take the combination and report any side e…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are very limited. Researchers will work with 30 adults who have both alcohol use disorder and recent suicidal thoughts, testing whether the…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to alcohol-related images in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks after taking either the drug or a placebo. T…

This pilot study will test whether it is possible to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions over 6 months, or be given guidance on finding …

This study will test a digital pill system that tracks when people with alcohol-related liver disease take their medication and provides personalized support. The goal is to see if this approach is practical and acceptable for improving medication adherence. Fifty adults who are …

This study looks at whether federal rule changes made during the COVID-19 pandemic helped more veterans get and stay on medications for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data f…

This study looks at how acceptable alcohol-related support programs are to patients and staff, and what social or economic factors influence whether people stick with them. Researchers will review data from about 2,000 patients and interview staff who provided the support. The go…

This study looks at how short-term inflammation changes mood and alcohol cravings in people with alcohol use disorder (AUD) compared to healthy volunteers. Researchers will give a low dose of a substance that causes temporary inflammation or a placebo to 64 adults. Participants w…

This study looks at how severe alcohol use disorder affects social thinking, like recognizing emotions and understanding others' thoughts. Researchers will use brain scans and smartphone tracking to compare 60 people with the disorder to healthy volunteers. The goal is to find br…

This study looks at how the liver processes fat in people with alcohol use disorder. Participants will have two liver biopsies: one soon after entering a detox program and another three weeks later. Researchers will compare genetic activity in the liver to understand how fat buil…

This study will test if a smart chatbot can help young adults aged 18-29 who drink heavily to reduce their alcohol use. The chatbot will have personalized conversations to encourage healthier drinking habits. The main goal is to see if young people find the chatbot easy and helpf…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the way people with alcohol use disorder adapt to change. About 30 adults receiving care at Paul Brousse Hospital will complete a computer task and questionnaires in one 45-minute sessi…