Obsessive-compulsive disorder

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether deep brain stimulation (DBS) — a device that sends electrical pulses to specific brain areas — can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive a DBS implant targeting two …

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

Researchers at Brigham and Women's Hospital are testing whether automated motivational messages or coach support can improve engagement with SilverCloud, a digital mental health intervention for depression and anxiety. The trial enrolls adults with clinically significant symptoms…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This study tests a personalized cognitive training program called CBM-TAF for adults with obsessive-compulsive (OC) symptoms. The program targets a specific thinking pattern known as thought-action fusion (TAF), where people believe having an unwanted thought is as bad as acting …

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tested a type of talk therapy called natural psychotherapy, based on Morita therapy and adapted for Chinese culture, in 80 adults with obsessive-compulsive disorder (OCD). The goal was to see if it could reduce OCD symptoms, measured by standard scales. Participants at…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tested a device called Reacor that uses biofeedback to teach mindfulness by showing your heart rate and brain waves in real time. 188 adults with anxiety disorders were split into three groups: biofeedback alone, the medication escitalopram alone, or both together. The…

This Phase 3 trial tested whether adding troriluzole to standard OCD medications could reduce symptoms better than a placebo. The study enrolled 589 adults with OCD who had not responded well enough to their current treatment. After 8 weeks, troriluzole did not lead to significan…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a 30-minute web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy. The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. Researchers recruited 47 parents and…

This study tested a brief virtual therapy called MAPP (Mindful Adaptive Practice in Pregnancy) to help pregnant women manage COVID-19-related anxiety. 69 women participated, comparing MAPP to usual care. The goal was to see if the therapy is feasible and acceptable, not yet to pr…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This completed Phase 1 trial tested transcranial direct current stimulation (tDCS) in 42 adults with obsessive-compulsive disorder (OCD). Participants received 10 sessions of either low-dose, higher-dose, or fake (sham) electrical stimulation over five days. The goal was to see i…

This study tested a type of therapy called Emotion Regulation Therapy - Attention Regulation (AR-ERT) to help people with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. 65 adults in Massach…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. The treatment targeted a brain area involved in movement planning. Researchers also looked for clues about how TMS works and …

This study tested a new way of delivering care for people with anxiety and depression in Danish general practices. 302 adults with conditions like panic disorder, social anxiety, or PTSD took part. The model involved a team of doctors, nurses, and therapists working together, and…

This study tested two types of online therapy for anxiety and depression in 2477 adults. Participants received either a cognitive behavioral treatment or a psychodynamic treatment, delivered over 8 or 16 weeks, with or without a support forum. The goal was to see which combinatio…

This completed study tested a free mobile app called Ísland that uses artificial intelligence and virtual reality to help teens aged 13–19 manage anxiety. The app combines four proven therapies, offers private journaling, video group sessions, and VR exercises to face fears safel…

This completed Phase 2/3 trial tested whether adding troriluzole to standard antidepressant treatment can reduce OCD symptoms. 426 adults with moderate-to-severe OCD who had not responded well enough to their current medication took either troriluzole or a placebo for 12 weeks. T…

This study tested whether a stepped-care internet-based cognitive behavior therapy (ICBT) with reduced support is as effective as traditional group therapy for obsessive-compulsive disorder (OCD). 95 adults with moderate to severe OCD took part. The goal was to see if the online …

This study tested an 8-week mindfulness-based psychoeducation program in 50 adults diagnosed with anxiety disorders. Half took the program, half did not. Researchers measured changes in perceived stress, intolerance of uncertainty, and cognitive flexibility. The goal was to see i…

This study tested whether adding troriluzole to standard OCD treatment works better than a placebo. It involved 456 adults with OCD who hadn't fully responded to their current medication. The main goal was to see if troriluzole could further reduce OCD symptoms and improve daily …

This study tested a mobile app called GGOC-AD designed to reduce obsessive-compulsive disorder (OCD) symptoms in adolescents aged 15 to 18. The app presents statements that users accept or reject to challenge unhelpful beliefs linked to OCD. Researchers compared the app to a neut…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This study tested a new, short, and intensive therapy called HANDS-ON for 12 teens (ages 10-18) with anxiety or obsessive-compulsive disorder (OCD) who hadn't improved with standard therapy. The treatment involved personalized exposure exercises done at home and school, with help…

This study tested whether virtual reality (VR) sessions can help reduce anxiety and depression in people aged 12 to 25 who do not want to take medication. Forty participants completed five weekly VR sessions focused on relaxation, coping skills, and healthy habits. Researchers me…

This study tested a single-session program for children ages 7 to 17 with anxiety and their parents. The program teaches kids how to manage anxious thoughts and feelings, and shows parents how to support them. Researchers wanted to see if this quick help could reduce anxiety symp…

This study tested a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) for Obsessive Compulsive Disorder (OCD). 30 adults with OCD received either real or fake (placebo) rTMS to see if it changes blood flow in a brain area linked to OCD. The goal was to understa…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested whether adding cognitive behavioral therapy (CBT) to a gradual benzodiazepine taper helps patients with anxiety who also take prescription opioids reduce their benzodiazepine use. 42 primary care patients were randomly assigned to receive either CBT or a health …

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study looked at whether watching short science videos can change how adults with anxiety think about psychological therapy. 262 participants watched 30 minutes of educational videos and filled out surveys about their beliefs and expectations. The goal was to understand if sc…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study tested whether non-invasive brain stimulation combined with computer-based training can change brain activity and reduce compulsive behaviors in people with OCD. 203 adults with problematic compulsions participated. The goal was to understand how a specific brain regio…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study tested a mobile app called esTOCma, a serious game designed to teach teachers about obsessive-compulsive disorder (OCD) and reduce stigma. 175 teachers used the app for 10 days or did nothing. Researchers measured changes in OCD knowledge, attitudes, and confidence in …

This study looked at how people with obsessive-compulsive disorder (OCD) balance between using habits and goal-directed thinking when making decisions. Researchers used brain scans and mild electrical stimulation to understand the brain circuits involved. The goal was to learn mo…

This study followed 559 children and teens ages 6 to 19 in the McLean Anxiety Mastery Program to see if their anxiety and depression improved with treatment. Researchers compared patients who received treatment to those on a waitlist and checked if gains lasted three months after…

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). Thirty-five adults with OCD completed 15 therapy sessions and had brain scans before, during, and after treatment. The goal…