Obsessive-compulsive disorder

This trial tests whether low intensity focused ultrasound (LIFU), a non-invasive technique that uses sound waves to stimulate deep brain regions, can safely ease symptoms of obsessive-compulsive disorder (OCD). Researchers will target the ventral striatum, an area linked to OCD, …

This trial tests an adaptive deep brain stimulation system for people with severe obsessive-compulsive disorder (OCD) that has not improved with standard treatments. The device, implanted in the brain, aims to detect brain signals linked to OCD distress and adjust its stimulation…

This study offers open/aftercare treatment to adults with obsessive-compulsive disorder (OCD) who have completed an earlier study at Stanford's Rodriguez Lab. Participants receive evidence-based psychotherapy and/or pharmacotherapy from trained professionals. The goal is to see i…

This trial explores whether adding vitamin D and iron supplements to usual OCD treatment can improve the ability to control impulses. It involves 60 people with OCD who will receive the supplements for 12 weeks. Researchers will use brain scans and behavioral tasks to see if thes…

This study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…

This study tests whether mindfulness-based therapy can help people with obsessive-compulsive disorder (OCD). Researchers will compare mindfulness to standard cognitive behavioural therapy (CBT) in 420 adults with OCD. The goal is to see if mindfulness reduces OCD symptoms and to …

This study tests deep brain stimulation, a device that sends electrical pulses to specific brain areas, for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Only 2 participants are enrolled. The goal is to see if this approach …

This study aimed to improve how deep brain stimulation (DBS) is targeted for people with severe obsessive-compulsive disorder (OCD). It planned to use brain scans to personalize the placement of electrodes. However, the trial was withdrawn before enrolling any participants, so no…

This study tests whether adding N-acetylcysteine (NAC) to standard treatment can help people with obsessive-compulsive disorder (OCD) that hasn't improved with other medications. Researchers will measure brain glutamate levels and symptom changes in 90 participants over 12 weeks.…

This study is testing whether artificial intelligence can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, autism, and schizophrenia. Researchers will record 500 people speaking and compare the AI's predictions to standard clinical dia…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

This early-phase study at Johns Hopkins University is testing whether psilocybin, the active compound in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty-five adults with moderate to severe OCD who have already tried other treatments will r…

This study compares two low-intensity family treatments for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD): internet-delivered cognitive behavioral therapy (CBT) and a parent-led reading program. Both are delivered via telehealth and compared to a relaxati…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This early study tests if a non-invasive technique called MRI-guided focused ultrasound can safely reduce symptoms in adults with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten participants will receive the ultrasound treatment and c…

This trial compares two forms of cognitive-behavioral therapy (CBT) for children and teens with anxiety or obsessive-compulsive disorder (OCD). One approach uses internet-delivered modules with therapist guidance; the other trains parents to lead exposure exercises with their chi…

This small early-phase study is testing whether psilocybin, the active ingredient in magic mushrooms, combined with supportive therapy can safely help people with obsessive-compulsive disorder (OCD) that hasn't responded to standard treatments. Ten adults with treatment-resistant…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests whether a single type of cognitive-behavioral therapy (CBT) can work for several anxiety disorders, compared to therapies designed for each specific disorder. About 76 adults with panic disorder, generalized anxiety, social anxiety, OCD, or PTSD will participate.…

This study looks at whether a therapist-guided online therapy program can help teens aged 12 to 17 with obsessive-compulsive disorder (OCD). The program uses cognitive-behavior therapy delivered over the internet. Researchers want to see if it's practical and acceptable, and if i…

This small pilot study tests whether giving a brief, non-invasive brain stimulation (rTMS) before cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) get better results. Ten adults with OCD will receive rTMS to improve thinking skills like …

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can reduce obsessive-compulsive disorder (OCD) symptoms in people who haven't gotten better with standard therapy. 43 adults with severe, long-lasting OCD will receive either real or fake stimulation…

This study tests whether the anti-inflammatory drug celecoxib (Celebrex) can reduce obsessive-compulsive disorder (OCD) symptoms in adults who are already on medication but still struggling. Researchers will use brain scans and blood tests to measure inflammation and see if it pr…

This study tests a 16-week cognitive behavioral therapy (CBT) program called the C.A.T Project for Pakistani teenagers aged 14 to 17 with moderate to severe anxiety. The program helps teens change unhelpful thoughts and behaviors using relaxation, problem-solving, and parent educ…

Researchers at Baylor College of Medicine are studying how brain activity and visible behaviors, like head movements, facial expressions, and voice tone, change during tasks that trigger OCD symptoms. Adults with OCD and healthy volunteers will complete tasks that provoke distres…

This study is testing whether functional MRI brain scans can predict and track how well children and teens with obsessive-compulsive disorder (OCD) respond to a type of therapy called Exposure and Response Prevention (ERP). Thirty participants aged 10 to 17 will receive 14 weekly…

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study looks at brain activity in people already receiving deep brain stimulation (DBS) for severe obsessive-compulsive disorder (OCD). Researchers will collect recordings from the implanted device to see how brain signals relate to OCD symptoms. The goal is to better underst…

This study explores whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce compulsive behaviors in people with anorexia nervosa. Twenty participants will receive multiple sessions of rTMS targeting a brain region l…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This early study tests an adaptive deep brain stimulation (aDBS) system in 2 people with severe, treatment-resistant OCD. The device records brain signals to identify patterns linked to OCD distress and stimulation side effects. The goal is not to treat OCD now, but to gather dat…

This study tests an adaptive deep brain stimulation (aDBS) system in just 3 people with severe, treatment-resistant OCD. The device is implanted in the brain and chest, and it aims to detect brain signals linked to OCD distress and adjust stimulation automatically. The main goal …

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study looks at 60 people with obsessive-compulsive disorder (OCD) who either respond well to medication, respond to brain stimulation, or don't respond to either. Researchers will take blood samples and turn them into nerve cells in the lab to study how these cells react to …

This study is developing and testing an online training program to teach therapists how to deliver exposure therapy to people with anxiety disorders and OCD. About 56 practicing therapists will try the program and give feedback to improve it. The goal is to see if the training re…

This study aims to identify brain-based subtypes of Obsessive-Compulsive Disorder (OCD) and see how they respond to two different targets of repetitive transcranial magnetic stimulation (rTMS). Researchers will use brain scans to measure connectivity in specific networks before a…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…