Brain implant learns to read OCD signals in tiny pilot study

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * OCD DBS Subject Inclusion criteria: 1. Signed informed consent prior to any study specific procedures being performed 2. Male or female between ages 21 and 70; 3. At least a five-year history of treatment-refractory OCD that causes substantial subjective distress and impairment in functioning; 4. Y-BOCS minimum score of 28; 5. Failed an adequate trial of at least three of the following SSRIs: Fluoxetine; fluvoxamine; citalopram; escitalopram; sertraline; paroxetine; 6. Failed an adequate trial of clomipramine; 7. Failed augmentation of one or more of the aforementioned drugs with at least one of the following antipsychotics: haloperidol; risperidone; quetiapine; ziprasidone; aripiprazole; 8. Failed an adequate trial of CBT for OCD, defined as 25 hours of documented exposure and response prevention (ERP) by an expert therapist; 9. Stable psychotropic medical regimen for the month preceding surgery * Non-Implanted Control Subject Inclusion criteria: 1. Signed informed consent prior to any study specific procedures being performed 2. Male or female between ages 21 and 70 * Implanted ET Subject Inclusion criteria: 1. Signed informed consent prior to any study specific procedures being performed 2. Male or female between ages 21 and 70 3. Diagnosed with Essential Tremor (ET) chronically, EXCLUDING head tremor, and implanted with DBS Exclusion Criteria: * OCD DBS Subject Exclusion criteria: 1. Inability or refusal to give informed consent. 2. Lifetime diagnosis of psychotic disorders such as schizophrenia; 3. Alcohol or substance abuse/dependence within 6 months, excluding nicotine; 4. Deemed at high risk of suicidal behavior or impulsivity, per clinical opinion assessments. 5. Any Neurological/Medical condition that makes the subject, in the opinion of the surgeon, a poor candidate. 6. Pregnant (confirmed by serum pregnancy test on females of child bearing age) or plans to become pregnant in the next 24 months. 7. Need for Diathermy 8. Contraindications to MRI * Non-Implanted Control Subject Exclusion criteria: 1. Inability or refusal to give informed consent. 2. Lifetime diagnosis of mental illness 3. A score of 8 or greater on part B of the Florida Obsessive Compulsive Inventory 4. Any neurological disorders (i.e., MS, Parkinson's Disease, seizure disorders, etc.) or evidence of brain abnormalities/injury, such as tumor, stroke, or traumatic brain injury 5. Pregnant (confirmed by self-report for females of child bearing age) 6. Contraindications to MRI * Implanted ET Subject Exclusion criteria 1. ET subjects (with DBS implanted), WITH head tremor, may exacerbate artifact, therefore they will be excluded. 2. Inability or refusal to give informed consent. 3. Lifetime diagnosis of mental illness 4. A score of 8 or greater on part B of the Florida Obsessive Compulsive Inventory 5. Any other neurological disorder other than ET (i.e., MS, Parkinson's Disease, seizure disorders, etc.) or evidence of brain abnormalities/injury, such as tumor, stroke, or traumatic brain injury 6. Contraindications to MRI