Obsessive-compulsive disorder

Researchers are testing whether a personalized form of brain stimulation can ease symptoms in people with anxiety disorders that have not improved with standard treatments. The approach uses a device to deliver rapid magnetic pulses to specific brain circuits, guided by each pers…

This study tests a non-invasive procedure that uses sound waves to target a small area in the brain thought to be involved in obsessive-compulsive disorder (OCD). It is for adults aged 25-64 with moderate to severe OCD that has not improved with standard treatments like therapy a…

This study tests whether deep brain stimulation (like a pacemaker for the brain) can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with medication. Four participants will have electrodes implanted and receive stimulation at one of two brain area…

This study will test whether an artificial intelligence (AI) system can diagnose anxiety disorders as accurately as a psychiatrist. One hundred adults with anxiety will be assessed by both the AI and a specialist, and the results will be compared. The goal is to see if the AI is …

This study tests whether digital exercises on a smartphone can help teens aged 16-19 avoid relapse of depression or anxiety. Participants who have recovered from a past episode will use a research app to work through thoughts and feelings while they feel well. Some will join onli…

Researchers test whether transcutaneous electrical acupoint stimulation, a non-invasive way to stimulate acupuncture points, adds benefit to exposure and response prevention therapy for adults with obsessive-compulsive disorder. The trial enrolls 90 people aged 18 to 50 with mode…

This pilot study tests whether MyFILM, a 9-week group program using clips from the movie Inside Out, is feasible and acceptable for children aged 9-12 with mood or anxiety concerns. Participants attend weekly sessions to learn social-emotional skills and coping strategies. The st…

This study tests whether a device that sends magnetic pulses to a specific brain area (dorsomedial prefrontal cortex) can safely reduce obsessive-compulsive behaviors in adults aged 22 and older. Participants receive either real or sham stimulation over six visits. The main goal …

This study tests BraveBot, a computer program that talks with young people (ages 12-22) through their phone or computer while they do exposure therapy homework for anxiety or OCD. BraveBot does not replace the therapist but offers real-time coaching and encouragement during assig…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). About 30 participants will receive either the drug or a placebo in a crossover design, meaning everyone gets both over time. The main goal is to …

This early-stage trial will test whether psilocybin, the active ingredient in magic mushrooms, can safely reduce symptoms of obsessive-compulsive disorder (OCD). Twenty adults with moderate-to-severe OCD who haven't responded to standard treatments will receive either a low (10mg…

This small study will test whether a type of brain stimulation called TMS can help new mothers with obsessive-compulsive disorder that started or worsened after childbirth. Fifteen women will receive 50 sessions over 10 days, along with brain scans and symptom checks. The goal is…

This early study tests whether a custom video game called Militant of the Maze can make exposure therapy for OCD more effective and engaging. Researchers will first have clinicians play and evaluate the game, then refine it and test it with a few non-clinician volunteers. The goa…

This study tests whether an AI-based rehabilitation program, combined with usual care, can reduce anxiety symptoms more than usual care alone. About 158 adults with anxiety disorders will use the AI system for 12 sessions over 3 weeks. The goal is to see if digital therapy can im…

This study tests a smartphone app designed to help teenagers in rural New Hampshire cope with anxiety. The app sends quick, personalized suggestions for calming activities. Fifty teens aged 13-17 with mild or worse anxiety will use the app for 3 months or be placed on a waitlist.…

This study tests whether provoking OCD symptoms right before a gentle brain stimulation technique (tDCS) can boost its effects. About 178 adults with treatment-resistant OCD will receive either tDCS alone or tDCS preceded by symptom provocation. The goal is to see if the combined…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests whether a culturally adapted self-help workbook based on cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) in Pakistan. 108 adults with OCD will use the manual over ten weeks, with guidance from a therapist. Researchers w…

This study tests a smartphone app called ZeroOCD that uses augmented reality to help people with contamination OCD face their fears. About 189 adults with OCD symptoms will be randomly assigned to use the app, receive standard therapy by video, or join a waitlist. The goal is to …

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebr…

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and the…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study looks at whether a type of brain stimulation called transcranial magnetic stimulation can help people with OCD shift their behavior more flexibly. It involves 12 participants who will receive three daily sessions of stimulation. The goal is to see if the procedures are…

This study looks at how people with anxiety make decisions to avoid things that make them anxious. Researchers will use brain scans and phone tracking to see how avoidance behavior works in the lab and in real life. About 163 adults with and without anxiety will take part. The go…

This study looks at how certain brain circuits cause strange sensory feelings in people with Obsessive-Compulsive Disorder (OCD). It will test if a non-invasive brain stimulation technique called rTMS can reduce these symptoms. The study involves 120 adults with OCD and healthy v…

This study will compare obsessive-compulsive symptoms in 102 adults with substance use disorder to a similar group without it. Participants will complete interviews and questionnaires to measure OCD severity, addiction severity, and quality of life. The goal is to understand how …

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study will follow 12 people with severe OCD or bipolar disorder who are already scheduled to receive deep brain stimulation (DBS). Researchers will use the DBS device to record brain activity while participants wear smart rings, watches, and phones to track sleep, activity, …