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Brain study reveals how OCD affects Decision-Making

NCT ID NCT04075890

Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how people with obsessive-compulsive disorder (OCD) balance between using habits and goal-directed thinking when making decisions. Researchers used brain scans and mild electrical stimulation to understand the brain circuits involved. The goal was to learn more about OCD, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Jul 2019

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

A) OCD participants inclusion criteria: 1. DSM-5 diagnostic criteria for OCD as primary (most severe) diagnosis (based on the Mini International Neuropsychiatric Interview). 2. Yale-Brown Obsessive-Compulsive Scale (YBOCS) total score is equal or greater than 16. 3. unmediated or being on a stable dose of medication (only SSRIs and clomipramine) for at least 12 weeks prior to the study. 4. fluent English speaker. 5. signed informed consent. B) OCD participants exclusion criteria: 1. IQ greater than 80 on the Wechsler Abbreviated Scales of Intelligence. 2. lifetime DSM-5 diagnosis of mania, psychotic disorder, or substance dependence (per MINI). 3. current DSM-5 diagnosis of MDD if Montgomery-Asberg Depression Scale (MADRS) scores are equal or greater than 35 (severe), or ADHD. 4. taking any psychotropic medication other than SSRIs or clomipramine. 5. severe psychiatric symptom that requires immediate inpatient psychiatric intervention such as suicidality. 6. presence of any serious psychiatric, psychosocial, or neurological condition requiring immediate treatment. C) Healthy control inclusion criteria: 1-males and females age 18-65 years with signed informed consent and IQ greater than 80 on WASI. D) Exclusion criteria for all participants: 1. presence of any MR scan contraindications particularly body metal or positive pregnancy test. 2. medical conditions in which cerebral metabolism might be compromised such as thyroid disorders, diabetes or current tobacco smoking (potential effect on imaging endpoints). 3. any history of seizure disorders.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder obsessive-compulsive personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Decision making FMRI OCD TDCS

Contacts and locations

Locations

  • UCLA

    Los Angeles, California, 90095, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.