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Could this pill help when OCD meds fall short?

NCT ID NCT04641143

Symptom relief Sponsor: Biohaven Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding troriluzole to standard OCD treatment works better than a placebo. It involved 456 adults with OCD who hadn't fully responded to their current medication. The main goal was to see if troriluzole could further reduce OCD symptoms and improve daily functioning.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

456 people

The number who actually took part.

Started

Dec 2020

Finished

Oct 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Primary diagnosis of obsessive-compulsive disorder (OCD) as per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition as confirmed by the MINI at Screening; The duration of the subject's illness must be ≥ 1 year 2. An inadequate response to current Standard of Care medication defined as selective serotonin reuptake inhibitor (excluding fluvoxamine) or clomipramine treatment at an adequate and stable dose for at least 8 weeks prior to screening and at least 12 weeks at baseline (adequate dose defined by USPI labeling); an inadequate response as defined per the MGH-TRQ-OCD, there has been minimal or no meaningful clinical benefit as perceived by the subject 3. Determined by the investigator to be medically stable at baseline/randomization as assessed by medical history, physical examination, laboratory test results, and electrocardiogram testing. Subjects must be physically able and expected to complete the trial as designed Exclusion Criteria: 1. Subjects with a history of more than two (2) previous failed or inadequate treatment classes given for an adequate duration at an adequate dose as defined by the MGH-TRQ-OCD. 2. Current or prior history of: bipolar I or II disorder, schizophrenia or other psychotic disorders, schizoaffective disorder, autism or autistic spectrum disorders, borderline personality disorder, antisocial personality disorder, Tourette's disorder, body dysmorphic disorder, hoarding disorder; or psychosurgery, Deep Brain Stimulation (DBS) or Electroconvulsive Therapy (ECT); or general medical condition that may confound safety and/or efficacy results 3. Previous treatment in a study with troriluzole

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive - compulsive disorder

Contacts and locations

Locations

  • AMR-Baber Research, Inc

    Naperville, Illinois, 60563, United States

  • APG Research, LLC

    Orlando, Florida, 32803, United States

  • Accel Research Sites

    Lakeland, Florida, 33803, United States

  • ActivMed Practices and Research

    Methuen, Massachusetts, 01844, United States

  • Advanced Clinical Research Network

    Coral Gables, Florida, 33134, United States

  • Altea Research

    Las Vegas, Nevada, 89102, United States

  • Anderson Clinical Research

    Redlands, California, 92374, United States

  • Axiom Research, LLC

    Colton, California, 92324, United States

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Behavioral Clinical Research

    North Miami, Florida, 33161, United States

  • Behavioral Research Specialists, LLC

    Glendale, California, 91206, United States

  • Bio Behavioral Health

    Toms River, New Jersey, 08755, United States

  • Bio Behavioral Institute

    Great Neck, New York, 11021, United States

  • BioBehavioral Research of Austin

    Austin, Texas, 78759, United States

  • Bioscience Research, LLC

    Mount Kisco, New York, 10549, United States

  • Boca Raton Medical Institute

    Boca Raton, Florida, 33431, United States

  • Boston Clinical Trials

    Boston, Massachusetts, 02131, United States

  • CBH Health

    Gaithersburg, Maryland, 20877, United States

  • CITrials (Clinical Innovations)

    Bellflower, California, 90706, United States

  • California Neuroscience Research Medical Group, Inc

    Sherman Oaks, California, 91403, United States

  • Central Miami Medical Institute

    Miami, Florida, 33125, United States

  • Central States Research, LLC

    Tulsa, Oklahoma, 74136, United States

  • Clarity Clinical Research

    Los Angeles, California, 90064, United States

  • Clinical Inquest Center, Ltd

    Beavercreek, Ohio, 45431, United States

  • Collaborative Neuroscience Research

    Torrance, California, 90502, United States

  • Collective Medical Research

    Overland Park, Kansas, 66210, United States

  • Combined Research Orlando Phase I-IV

    Orlando, Florida, 32807, United States

  • Comprehensive Psychiatric Care

    Norwich, Connecticut, 06360, United States

  • Comprehensive Psychiatric Care Providers

    Providence, Rhode Island, 02906, United States

  • Conquest Research LLC

    Winter Park, Florida, 32789, United States

  • Excell Research, Inc

    Oceanside, California, 92056, United States

  • FIRC

    Miami, Florida, 33173, United States

  • Florida Research Center, Inc.

    Miami, Florida, 33174, United States

  • Hassman Research Institute

    Berlin, New Jersey, 08009, United States

  • Health Care Family Rehab & Research

    Miami, Florida, 33015, United States

  • IMA Clinical Research

    Phoenix, Arizona, 85012, United States

  • Innovative Clinical Research, Inc.

    Lauderhill, Florida, 33319, United States

  • Integrative Clinical Trials, LLC

    Brooklyn, New York, 11229, United States

  • Lumos Clinical Research Center, LLC

    San Jose, California, 95124, United States

  • Manhattan Behavioral Medicine, PLLC

    New York, New York, 10036, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • MedBio Trials

    Pembroke Pines, Florida, 33026, United States

  • Medical Research Group of Central Florida

    Orange City, Florida, 32763, United States

  • Metropolitan Neuro Behavioral Institute

    Chandler, Arizona, 85284, United States

  • Michigan Clinical Research Institute PC

    Ann Arbor, Michigan, 48105, United States

  • Mt.Olympus Medical Research LLC

    Missouri City, Texas, 77459, United States

  • NRC Research Institute

    Orange, California, 92688, United States

  • Neurobehavioral Research, Inc

    Cedarhurst, New York, 11516, United States

  • Neurobehaviorial Institute

    Weston, Florida, 33326, United States

  • NoeisisPharma, LLC

    Phoenix, Arizona, 85016, United States

  • North Texas Clinical Trials

    Fort Worth, Texas, 76104, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Northwest Clinical Trials

    Boise, Idaho, 83704, United States

  • Omega Research Consultants

    Orlando, Florida, 32808, United States

  • Pharmacology Research Institute

    Los Alamitos, California, 90720, United States

  • Pharmasite Research, Inc.

    Pikesville, Maryland, 21208, United States

  • Precise Research Centers

    Flowood, Mississippi, 39232, United States

  • Psychiatric Care and Research Center

    O'Fallon, Missouri, 63368, United States

  • Relaro Medical Trials

    Dallas, Texas, 75243, United States

  • Research in Miami Inc

    Hialeah, Florida, 33013, United States

  • Revive Research Institute

    Elgin, Illinois, 60123, United States

  • Richmond Behavioral Associates

    Staten Island, New York, 10312, United States

  • Sisu at RMG

    Springfield, Massachusetts, 01103, United States

  • South Florida Research Phase I-IV , Inc.

    Miami Springs, Florida, 33166, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Stedman Clinical Trials

    Tampa, Florida, 33613, United States

  • Suburban Research Associates

    Media, Pennsylvania, 19063, United States

  • Texas Center for Drug Development, Inc.

    Houston, Texas, 77081, United States

  • Uptown Research Institute

    Chicago, Illinois, 60640, United States

  • WR-PRI, LLC (Encino)

    Encino, California, 91316, United States

  • Yale University / Connecticut Mental Health Center

    New Haven, Connecticut, 06519, United States

  • iResearch Atlanta, LLC

    Decatur, Georgia, 30030, United States

  • iResearch Savannah

    Savannah, Georgia, 31405, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.