Gram-positive bacterial infections

Researchers are testing whether a 13-valent pneumococcal conjugate vaccine is safe and prompts a strong immune response in healthy infants in India. The trial enrolls 708 infants who receive the vaccine or an older seven-strain version alongside their routine childhood shots. The…

Researchers are testing a new vaccine called LBVD that combines protection against diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib into a single injection. The study will enroll healthy infants aged 6 to 8 weeks, who will receive three doses at 6, 10, and 14 week…

This trial evaluates a new five-component vaccine (Tdcp) designed to protect against diphtheria, tetanus, and pertussis (whooping cough). It includes about 1,820 participants aged 7 and older, who receive either the experimental vaccine or a control vaccine. The study measures ho…

This early-stage trial is testing a new vaccine called V-212, designed to protect against pneumococcal disease caused by the bacterium Streptococcus pneumoniae. The study involves 60 healthy adults aged 18-45 who will receive either the vaccine or a placebo in three doses. Resear…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This phase II trial tests a new 24-valent pneumococcal conjugate vaccine (PCV24) in 992 adults aged 18 and older. The study aims to check the vaccine's safety and how well it triggers an immune response compared to an existing 23-valent vaccine. Participants receive one dose of e…

This early-stage trial is testing a new vaccine called PCV24, designed to protect children against 24 types of pneumococcal bacteria. The study involves 230 healthy children aged 6 weeks to 17 years and will check for side effects and measure immune response. The vaccine is given…

This trial is testing a new tetanus vaccine in healthy adults aged 18 to 43. The goal is to see if the vaccine is safe and triggers a strong immune response, measured by antibody levels one month after vaccination. Participants will receive either the new vaccine or a control vac…

This study tests a new vaccine (RZ700) designed to protect infants and young children against 24 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. About 480 healthy children aged 6 weeks to 71 months will receive the vaccine to see if it t…

This study tests a 13-valent pneumococcal conjugate vaccine in healthy children aged 15 months to 17 years. The goal is to see if the vaccine is safe and triggers a strong immune response against 13 types of pneumococcal bacteria. Participants receive one or two doses, and resear…

This study tests an experimental vaccine called GBS-NN/NN2 against Group B Streptococcus (GBS), a bacteria that can cause serious infections in newborns. The trial includes pregnant women both with and without HIV, giving two doses between 26 and 30 weeks of pregnancy. Researcher…

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This study tested new pneumococcal vaccines in over 1,300 adults aged 18 and older to see if they are safe and help the body fight off pneumococcal disease. Participants received one shot of either a new vaccine or an existing one, and were monitored for side effects and immune r…

This study tested a new vaccine called Pn-MAPS30plus to see if it is safe and helps the body fight pneumonia-causing bacteria. It involved 127 healthy adults aged 50 to 64. The vaccine is designed to protect against more types of the bacteria than current vaccines.

This phase 3 trial tested a 13-valent pneumococcal vaccine (13vPnC) against the older 7-valent version in over 1,600 healthy infants in China. The goal was to see if the newer vaccine triggers a stronger immune response and is just as safe. Infants received four doses starting at…

This Phase 3 trial tested a new anthrax vaccine called AV7909 in nearly 3,700 healthy adults. The vaccine aims to protect people after they have been exposed to anthrax bacteria. Results showed that AV7909 produced a strong immune response and was safe, similar to the current lic…

This study tested a new 24-valent pneumococcal conjugate vaccine (PCV24) in 385 healthy adults aged 18 and older. The goal was to check its safety and how well it triggers an immune response compared to an existing vaccine. Participants received one dose of either a low, middle, …

This completed Phase I/II trial tested a new 26-valent pneumococcal conjugate vaccine in 450 people aged 2 months and older. The goal was to check safety and how well the vaccine triggers an immune response compared to existing vaccines. Researchers monitored side effects and ant…

This study tested a new vaccine designed to protect against 25 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 220 healthy adults aged 18 to 49 received either the new vaccine or an existing one to compare safety and immune response. …

This study tested a new vaccine called V116 in 882 children and teenagers aged 2 to 17 who have a higher risk of pneumococcal disease due to conditions like diabetes or chronic lung disease. The goal was to see if V116 is as good as or better than the current vaccine PPSV23 at tr…

This study tested a new pneumococcal vaccine in 225 healthy toddlers aged 12 to 15 months. The goal was to check safety and how well the vaccine triggers an immune response. Participants received either one or two doses and were monitored for side effects and antibody levels over…

This completed study tracked over 10,000 people in Thailand who received the Boostagen® vaccine, which protects against tetanus, diphtheria, and whooping cough. Healthcare workers reported any side effects to see how safe the vaccine is in everyday use. The study also looked at p…

This completed Phase 3 study tested a new vaccine called V116 in 518 adults aged 18 to 64 who are at increased risk for pneumococcal disease due to conditions like diabetes or chronic lung disease. The vaccine targets 21 strains of the bacteria that cause pneumonia and other infe…

This study tested a new 20-valent pneumococcal vaccine (20vPnC) against an existing 13-valent vaccine in 400 adults aged 50 and older in China who had never received a pneumococcal vaccine. The goal was to check safety and immune response. Results will help decide if the broader-…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This completed phase 1b trial tested a new 13-valent pneumococcal conjugate vaccine (PCV13) in 140 healthy infants (2 months old) and children (2-5 years). The goal was to check safety and immune response compared to an existing vaccine. Researchers monitored side effects and ant…

This early-stage trial tested a new 24-valent pneumococcal conjugate vaccine in 119 healthy children aged 2 to 17. The goal was to see if the vaccine is safe and helps the body build immunity against pneumococcal bacteria, which can cause pneumonia and other serious infections. R…

This early-phase study tested a new 13-valent pneumococcal conjugate vaccine in 310 healthy volunteers ranging from 6-week-old infants to adults up to 49 years old. The goal was to check the vaccine's safety and how well it triggers the immune system to fight pneumococcal bacteri…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This study tested a booster dose of the DTaP vaccine (BK1301) in 446 adolescents aged 11-12 who had already received the standard childhood series. The goal was to confirm the vaccine boosts immunity against diphtheria, tetanus, and pertussis (whooping cough) safely. Results show…

This early-stage trial tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy people aged 2 and older. Participants received one dose of either the experimental or a control vaccine. The study checked for side effects and measured immune response through blood …

This study tested a new vaccine (20vPnC) that protects against 20 types of pneumococcal bacteria, which can cause pneumonia and meningitis. Over 500 healthy infants in India and Taiwan received either the new vaccine or an existing one (13vPnC) as a series of four shots. Research…

This study tested a two-step vaccine approach in 70 adults who had their spleen removed. Participants received one shot of a conjugate vaccine followed by a second shot of a polysaccharide vaccine two months later. The goal was to see if this combination triggers a strong immune …

This early-stage trial tested whether a new whole-cell pneumonia vaccine is safe for people. Thirty healthy adults received either the vaccine or a placebo and were monitored for 30 days. The main goal was to check for side effects like pain, fever, or headache. This study does n…

This completed study looked at how effective the Prevnar 13 (PCV13) vaccine is at preventing pneumonia and related infections in adults with HIV. Researchers analyzed health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The g…

This study tested a new combination vaccine called Shan6™, which protects against six diseases (diphtheria, tetanus, whooping cough, hepatitis B, Hib, and polio) in healthy infants and toddlers in Thailand. The trial involved 460 participants and compared Shan6™ to a similar 5-in…

This study tested a new vaccine called VAX-24, which targets 24 types of pneumococcal bacteria, in 802 healthy infants. The babies received four doses at 2, 4, 6, and 12-15 months old, alongside routine vaccines. The goal was to check safety and how well the vaccine triggers an i…

This study tested three new pneumococcal vaccine formulations in 750 healthy adults aged 50 to 84. The goal was to see how well they trigger an immune response and how safe they are compared to two existing vaccines. Participants received a single shot, and researchers measured a…

This early-stage trial tested a new vaccine against Group B Streptococcus (GBS) in 90 healthy adults aged 55 to 75. Participants received three doses of the vaccine or a placebo, and researchers monitored safety and immune response for six months. The goal is to see if the vaccin…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This trial tests an experimental antibiotic called BTZ-043 in adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants take the drug by mouth once daily for 14 days, and researchers compare it to a standard combination treatment. The main goal is to check …

This study tested a single booster dose of a recombinant botulinum vaccine in 25 healthy adults who had already been vaccinated against botulism for work. The goal was to see if the booster safely raises their antibody levels enough to donate plasma for making BabyBIG, a treatmen…

This study looks at whether giving the Tdap vaccine every 3 months for a year is safe for healthy plasma donors. Normally, this vaccine is given once every 10 years. The goal is to see if more frequent vaccination produces high levels of tetanus antibodies in the plasma, which co…

This trial investigates whether giving two different pneumonia vaccines—one followed by another a year later—boosts immune protection more than a single vaccine alone in adults who have had their spleen removed. People without a spleen are at higher risk for serious pneumococcal …

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This completed Phase 1/2 trial tested a new lab-made antibody called SNA02-48 for treating tetanus in 255 Chinese adults. The study compared SNA02-48 to the standard treatment (human tetanus immunoglobulin) to see if it is safe and how well it works. The goal is to find a more re…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested whether charcoal-infused toothbrushes remove plaque and stains better than regular nylon toothbrushes. Thirty-six Egyptian adults brushed twice daily for 4 weeks with standard toothpaste. Plaque and stain levels were measured at the start and end. The goal is to…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested a single dose of the antibiotic oritavancin in 41 children under 18 with suspected or confirmed bacterial infections. The goal was to find the right dose and check for safety and side effects. It was an early-stage trial, so it focused on how the drug moves thro…

This study tests a new delayed-release metronidazole capsule designed to release the drug directly in the colon, where C. diff bacteria live. 18 healthy adults will receive a single dose of either the new capsule or the standard tablet to compare how much drug reaches the colon v…

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This small pilot study tested a drug called 3,4-diaminopyridine (FIRDAPSE) in 3 people with severe botulism who needed a ventilator to breathe. The goal was to see if the drug could improve nerve signals and breathing. Because only 3 people took part, the results are very prelimi…

This study tested an experimental drug called TNM002 in 240 healthy Chinese adults to see if it can protect against tetanus as well as the standard treatment. Participants received a single injection of TNM002 at different doses, the standard tetanus antibody, or a placebo. The m…

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

This study tested whether a rapid molecular test using saliva can accurately diagnose strep throat in children aged 3-15. Researchers compared the saliva test to standard throat swab methods in 800 children visiting primary care. If accurate, this could replace uncomfortable thro…

This phase 3 trial compares a new lab-made antibody, TNM002, with the standard human tetanus immunoglobulin for preventing tetanus in adults with dirty or contaminated wounds. Participants receive one injection of either treatment, and researchers measure whether their blood reac…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This early-stage trial is testing an experimental vaccine designed to protect people aged 6 and older against diphtheria, tetanus, and pertussis (whooping cough). The study will enroll 180 participants to check the vaccine's safety and how well it triggers an immune response. Som…

This trial is testing whether a single dose of an experimental tetanus vaccine is safe and triggers a protective immune response in adults aged 18 and older. Participants will receive either the new vaccine or a control vaccine, and researchers will measure antibody levels and mo…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested a new vaccine called V116 in adults aged 50 and older to see if it is safe and works better than the current vaccine (PPSV23) at preventing pneumococcal disease, which can cause pneumonia and other serious infections. About 1,500 healthy adults received either V…

This study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…

This study tested a two-step vaccine approach to prevent pneumococcal infections in 26 adults with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The vaccines, Prevenar and Pneumovax, were given in a prime-boost sequence to boost immune protection. …

This study tested a new vaccine called V116 in 313 adults with HIV to see if it safely prevents pneumococcal disease (a serious infection that can cause pneumonia and meningitis). Participants received either V116, a placebo, or an existing vaccine. The trial is complete, and res…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tested whether a structured collaboration between pharmacists and doctors could improve pneumococcal vaccination rates in patients at high risk for infection. Over 600 hospitalized adults with chronic conditions or weakened immune systems took part. The pharmacist revi…

This study tested a new pneumococcal vaccine (V116) given at the same time as the seasonal flu shot in 1,080 adults aged 50 and older. The goal was to see if giving both vaccines together is safe and produces a strong immune response. Results help determine whether combining thes…

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old. The goal was to see if it is safe and triggers a strong immune response against pneumococcal bacteria, which can cause pneumonia and other serious infections. Researchers compared AFX3772 with e…

This study in Blantyre, Malawi, compares two schedules of the pneumococcal conjugate vaccine (PCV13): the current 3-dose schedule without a booster (3+0) versus a 2-dose schedule with a booster at 9 months (2+1). The goal is to see if the booster reduces carriage of vaccine-type …

This study tested several non-drug methods—like a textured plastic device called ShotBlocker, a vibrating ice pack (Buzzy), and a skin-tapping technique—to reduce pain from injections in children aged 4 to 6. 120 kids in a pediatric emergency department took part. The goal was to…

This study tested a special way to give intramuscular injections to children aged 6-12. Instead of the usual method, nurses used a precise ventrogluteal technique with a 90-degree angle and quick needle insertion and removal. The 90 children were split into two groups: one got th…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This observational study aims to measure tetanus antibody levels in healthy adults living in Beijing, China. Researchers will analyze how antibody protection varies across different age groups and whether vaccination history predicts current immunity. Participants provide a singl…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This completed study monitored 1560 adults hospitalized with invasive pneumococcal infections (excluding meningitis) across France. Researchers collected information on infection severity, risk factors, and bacterial serotypes to understand how these infections occur and how vacc…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This completed early-phase study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious heart disease. Researchers safely exposed 40 healthy adults aged 18-40 to a specific strain of Strep A under controlled conditions. The goal was to see h…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study looked at 688 adults hospitalized with pneumonia in 11 hospitals in Colombia to find out how many cases were caused by pneumococcal bacteria. Researchers also identified which bacterial strains were most common and whether current vaccines cover them. The goal is to he…

This study tested whether giving a personalized dose of the antibiotic vancomycin to critically ill children in the ICU leads to better results than the standard approach. Researchers enrolled 314 children and compared how many reached the target drug level in their blood. The go…

This study looked at whether exposure to PFAS chemicals (found in some water supplies) can weaken the body's immune response to the tetanus and diphtheria booster vaccine. Twenty adults from a community with known PFAS exposure received the vaccine and had blood and saliva sample…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This study looked at whether a clinical pharmacist could help increase pneumococcal vaccination rates in patients at high risk for infection when they leave the hospital. Researchers tracked how many vaccine prescriptions were given to 167 at-risk adults. The goal was to see if t…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This study looked at how the COVID-19 pandemic and related measures like lockdowns and mask-wearing affected severe Group A Strep infections in children in Paris. Researchers reviewed medical records of 269 children under 18 admitted to a Paris hospital between 2018 and 2023. The…

This study looked at whether giving the anthrax vaccine AV7909 along with common antibiotics (ciprofloxacin or doxycycline) changes how the body processes those antibiotics. 210 healthy adults received the vaccine and antibiotics on a set schedule. The goal was to see if the vacc…

This completed study looked at how group B streptococcus (GBS) bacteria colonize the digestive tract of newborns. Researchers followed nearly 950 mothers and their babies, taking samples from the mother and umbilical cord at birth. The goal was to see if a specific, more dangerou…