Study: common chemicals could weaken vaccine power
NCT ID NCT06588530
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether exposure to PFAS chemicals (found in some water supplies) can weaken the body's immune response to the tetanus and diphtheria booster vaccine. Twenty adults from a community with known PFAS exposure received the vaccine and had blood and saliva samples taken over 30 days. The goal was to measure antibody levels and see if higher PFAS levels led to lower protection.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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20 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participated in the Paulsboro PFAS Health Study * Provided a blood sample for the Paulsboro PFAS Health Study * Weigh at least 110 pounds Exclusion Criteria: * Currently Pregnant * History of difficult blood draws * History of adverse reaction to prior vaccinations * Currently taking immune suppressants * Recent dental surgery or dental procedure within 4 weeks of starting study * Had a Td booster in the past 10 years
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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EOHSI Paulsboro Office
Paulsboro, New Jersey, 08066, United States
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Other studies related to the condition(s) this trial covers.
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